Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"CIMP"”.
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Impact of the gut microbiota on DNA methylation in colorectal cancer
The CpG Island Methylator Phenotype (CIMP) is a distinct form of aberrant DNA methylation in cancer, and it is seen in 20-40% of colorectal cancers (CRC) where its causes remain elusive. Intestinal microbiota represents an important environmental component implicated in CRC development. …
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Clinical importance of microsatellite instability and promoter methylation of DNA in colorectal cancer // Клинично значение на микросателитната нестабилност и промоторното метилиране на ДНК при колоректален карцином
… продукция на муцин и лимфоцитна реакция. CIMP-фенотипът се асоциира с напреднала възраст, проксимална локализация, ниска степен на диференциация и инфилтрация в чревната стена. По-ниска преживяемост е налице при туморите с метилиран hMLH, CIMP-фенотип и секреция на муцин. Адювантната …
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Rna-Sequencing Applications: Gene Expression Quantification and Methylator Phenotype Identification
… to identify the CpG island methylator phenotype (CIMP) by integrating datasets of mRNA expression level and DNA methylation status.</p> <p>Section 1: The cost of DNA sequencing has reduced dramatically in the past decade. Consequently, genomic research increasingly depends on sequencing …
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Το μικροβίωμα του παχέος εντέρου στην καρκινογέννεση. Κλινική αξία στην πρόγνωση και θεραπεία της νόσου
… (MSI) και του φαινοτύπου μεθυλίωσης CpG νησίδων (CIMP). Αυτές οι οδοί οδηγούν σε συσσώρευση γενετικών και επιγενετικών αλλοιώσεων που προάγουν τη μετατροπή φυσιολογικού επιθηλίου σε καρκινικό. Το εντερικό μικροβίωμα διαδραματίζει καθοριστικό ρόλο τόσο στη φυσιολογία όσο και στην παθογένεση του …
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EBV-Associated Gastric Cancer: From Initial Infection to Unique Therapeutic Approaches
… known as a CpG island hypermethylator phenotype (CIMP). EBV infection of B cells can be easily modeled in vitro using primary B cells and lymphoblastoid cell lines (LCLs). However, epithelial cell infection models have proven much more difficult to develop. Given these difficulties, EBV infection …
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The Role of Epigenetics in Hereditary Colorectal Cancer Tumorigenesis: Validation of Genome-Wide Methylation Array Results through Bisulfite Sequencing
Colorectal cancer (CRC) poses a considerable global health challenge, with high mortality rates despite advancements in cancer research. Approximately one in ten CRC cases have a hereditary basis, with Lynch syndrome and Familial adenomatous polyposis standing as the two predominant …
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Epigenetic Modification as a Therapeutic Target in BRAFV600E-mutated Metastatic Colorectal Cancer
<p>Patients with BRAF<sup>V600E</sup>-mutated metastatic colorectal cancer (mCRC) experience a worse prognosis and demonstrate only a 5% response rate to BRAF inhibitor treatment. In this study, adaptive resistance, and a potential combination of standard therapies in BRAF<sup>V600E</sup> CRC were …