Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"CIITA"”.
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Unraveling the molecular mechanisms of the class II transactivator, CIITA in skeletal muscle
… also induces the class II transactivator, CIITA, which is a critical mediator of IFN-gamma mediated repression and activation. The aims in my dissertation are directed towards understanding the role of IFN-gamma and CIITA in muscle. Stimulation by IFN-gamma in skeletal muscle cells induces …
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Die Rolle der DNA-Methylierung in der Kontrolle des MHC-II-spezifischen Typ-IV-Promotors in Thymomen
… durch den sogenannten Class II Transaktivator (CIITA) bestimmt. Die Transkription von CIITA wird über vier alternative, gewebsspezifische Promotoren durch alternatives splicing reguliert. Unter diesen Splicevarianten ist der CIITA Typ IV Promotor für die konstitutive MHC II-Expression in …
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Histopathology of livers and native organs of recipients following genetically-engineered pig-to-baboon liver xenotransplantation
… patch transplants from GE pigs (either GTKO/CD46/CIITA-DN; Group 1,n=8 or GTKO/CD46; Group 2,n=4). One baboon in Group 1 received no immunosuppressive therapy. Group 1A(n=2) received abatacept-based regimen. Groups 1B(n=3) received belatacept-based regimen and Group 1C(n=2) received a regimen …
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Expression Profiles of Molecules Involved in Antigen Presentation in Gangliosides-stimulated Primary Astrocytes from Rat brain
… the mRNA expression of class II transactivator (CIITA) and class II major histocompatibility (MHCII) molecules, using RT-PCR and real-time PCR. Gangliosides induce CIITA mRNA expression, followed by MHC II in astrocytes, but not in microglia. Critical for the development of mature APC capability …
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Interference of Toxoplasma gondii with IFN-γ-regulated gene expression of its host cell
… ist die Expression des class II transactivator (CIITA) geringer als in nicht infizierten bzw. nicht Parasitenlysat behandelten Kontrollzellen. Bezeichnenderweise beeinflussen nur lebende Parasiten die Expression des interferon regulatory factor-1 (IRF-1). Des weiteren verringern beide, lebende T. …
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Studio dei tratti immunofenotipici e valutazione del loro contributo nell'insorgenza di patologie
… the associated loci, four of them (HLA, IL2RA, CIITA, ATXN2/SH2B3) are known to be associated with immune and non-immune diseases, indicating the relevance of this approach for identification of immune-related genetic factors in health and disease.
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The genomic anchors of the human major histocompatibility complex
… was verified using hybridisations of CIITA-enriched DNA and DNA enriched in H3-K9/K14 acetylation. The findings reveal that MARs are unevenly distributed across the MHC, and that they can be classified into three classes: constitutive, cell type specific and transcriptiondependent. …
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Phenotypic and Functional Characterisation of Hofbauer Cells Across Gestation
… and the master regulator transcription factor CIITA was reduced in first trimester HBC compared to full-term HBC and monocytes. Lastly, monocyte-derived macrophage cultures demonstrated the importance of M-CSF for driving key features of the HBC phenotype. In summary, the results presented in …
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The neonatal anti-viral response fails to control measles virus spread in neurons despite interferon-gamma expression and a Th1-like cytokine profile
… robust induction of the IFNg-responsive genes CIITA and CXCL9. This suggests that IFNg signaling may be defective in the induction of IFNg-responsive genes in neonates compared to adults.</p> <p>To dissect the role of individual components of the immune system, we utilized CD46+ mice crossed to …