Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"CICR"”.
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Cell coupling and exocytosis measured in intact mouse pancreatic islets Control of {delta}-cell secretion
… feature results from Ca2+-induced Ca2+-release (CICR) via ryanodine receptor 3 (RyR3). Both somatostatin release measurements and patch-clamp experiments indicate that R-type Ca2+-channels are tightly coupled to CICR. The latency between Ca2+-influx through R-type Ca2+-channels and CICR was <6 …
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Spatial organization of sodium calcium exchanger and caveolin-3 in developing mammalian ventricular cardiomyocytes
… coupling is calcium-induced calcium release (CICR) mediated by L-type Ca2+ channels (Cav1.2). Briefly, membrane depolarization opens voltage-gated Cav1.2 to allow for the influx of extracellular Ca2+ into the cytosol. This small sarcolemmal (SL) Ca2+ influx is necessary for triggering a larger …
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The Role of Protein S-glutathionylation on Ca2+ Signaling in Cultured Aortic Endothelial Cells
… (IICR) and Ca2+-induced Ca2+-release (CICR) via IP3Rs. Since IP3 is not changing during challenge with diamide, our results indicate diamide primarily increases the sensitivity of IP3Rs to cytosolic Ca2+, i.e. enhanced CICR. Consistent with GSH-dependent thiol-modification, this …
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cAMP and Calcium Interactions in Endocrine Cells
… Ca<sup>2+</sup> induced Ca<sup>2+</sup> release (CICR) was observed when αMSH was applied with the three PDE inhibitors. When αMSH was applied without a PDE inhibitor there was no increase in [cAMP]<sub>c</sub>, suggesting a micro domain. Extracellular solutions of 2mM glucose with PDE inhibitors …
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Modulation of neuronal ryanodine receptor-mediated calcium signaling by calsenilin
… the RyR, modulating Ca2+ induced Ca2+ release (CICR) pathways in neuronal cells. Further characterization of this interaction and its pharmacological and molecular biological control could provide insight into altered Ca2+ signaling in neurodegenerative and other diseases controlled by CICR and …
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Cholinergic Regulation of Circadian Rhythms in the SCN: Characterization of Signaling Mechanisms and the Role of Intracellular Calcium in the Directionality of Clock Resetting
… block it. In contrast, selective activation of CICR with ryanodine results in glutamate-like delay. Ca 2+ imaging using multiphoton microscopy revealed signal-specific differences in Ca2+ transients. Cholinergic-stimulated Ca2+ transients are localized to the microdomains in the cytoplasm, …
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Calcium-dependent mechanisms in the chicken retina
… Inhibiting the calcium-induced calcium release (CICR) also decreased the Ca2+ current amplitude. These results indicate that MCU, PKA and CICR are critical to maintain the availability of L-type Ca2+ channels for depolarization-dependent signaling in amacrine cells. Production of nitric oxide …
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High-resolution optical analyses of inositol 1,4,5-trisphosphate receptors and the Ca²⁺ puffs they evoke
… property which allows Ca²⁺-induced Ca²⁺ release (CICR) between neighbouring IP₃Rs on the endoplasmic reticulum membrane. The assembly of IP₃Rs into small clusters allows local CICR to generate brief, localised increases in cytosolic Ca²⁺ concentration ([Ca²⁺]<sub>c</sub>), known as Ca²⁺ puffs, …
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MODULATION AND INTERACTIONS OF CHARGED BIOMIMETIC MEMBRANES WITH BIVALENT IONS
… to simulate calcium induced calcium release (CICR) that occurs in many cell types. In the final chapter, I provide a general conclusion and present directions for future research that would build on my findings.</p>
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Functional Importance of Oxidative Post-Translational Modifications of Ryanodine Receptor in Cardiac Sarcoplasmic Reticulum Ca2+ Handling During Oxidative Stress
<p>Free ionic calcium (Ca2+) plays an essential role as a second messenger that initiates muscle contraction in the heart. Ryanodine receptor (RyR2) acts as the primary Sarcoplasmic Reticulum (SR) Ca2+ release channel in the heart. In the event that intracellular SR Ca2+ handling is compromised, …
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5 ns Electric pulses evoke longer-lived calcium responses in adrenal chromaffin cells than the physiological stimulus: an experimental and computational study
… prolonged calcium-induced calcium release (CICR) from the endoplasmic reticulum (ER), and sustained membrane depolarization that may prolong the opening of VGCCs. In addition, our refined simulations showed that despite the very different geometries of the exposure systems, the electric …