Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 2 of 2 for “"CHP1"”.
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Deciphering Cancer Metabolic Dependencies in the Tumor Microenvironment
… identified calcineurin B homologous protein 1 (CHP1) as a major regulator of ER glycerolipid synthesis and saturated lipid toxicity. Mechanistically, CHP1 binds and activates GPAT4, which catalyzes the initial rate-limiting step in glycerolipid synthesis. GPAT4 activity requires CHP1 to be …
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Investigation of Diverse CARF Effectors in Type III CRISPR - Cas Immunity
… I characterized are closely related homologs Chp1 and Chp2 (CRISPR-associated HAD phosphatase). These proteins were first identified in a deep search bioinformatics study.1I determined that these proteins function by inducing a growth arrest in the cell through depletion of essential NTPs. …