Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"CHK"”.
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Novel peptide-based approaches to study the activity and substrate specificity of protein kinases
… kinase, C-terminal Src kinase homologous kinase (CHK). In addition to phosphorylating SFKs, CHK is known to perform other non-SFK-related cellular functions. Identifying the protein substrates of CHK that mediate its non-SFK function is an avenue to elucidate the molecular basis of the non-SFK …
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Investigating Checkpoint Kinases 1/2 As Novel Therapeutic Targets In Head and Neck Squamous Cell Carcinoma
… targeted inhibition of checkpoint kinases Chk1/2 leads to cisplatin sensitization of p53-deficient cells through induction of mitotic death. Serendipitously, we also found out that a significant subset (roughly 20%) of HNSCC cell lines are acutely sensitive to single agent checkpoint …
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Developing 1,2,3,4-tetrahydro-5H-aryl[1,4]diazepin-5-ones and Related Scaffolds as Poly-(ADP-ribosyl) Polymerase (PARP) Inhibitors and Exploring Their Targeted Polypharmacology with Kinases
… and cell-cycle checkpoints (such as CDKs, CHK, and Wee) are being tested. In this context, the synthetic lethality of cyclin-dependent kinase 1 (CDK1) and PARP1 is known. Evaluation of PARP1 and CDK1 pharmacophores led to the development of the tetrahydro-arylazepinone (TAAP) scaffold as a …
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Vitamin D- induced down regulation of RAD51 in head and neck squamous cell carcinoma (HNSCC), In Vitro and In Vivo
… studies examined the potential of Chk 1 and p38 MAPK as upstream regulators of Rad51. Rad51 protein expression was found to be associated with early carcinogenesis from HNSCC cancer patients using IHC studies of human carcinomas from the oral cavity. This study focused on further …
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Characterization of A Novel Role For The to usled- Like Kinase In Kinetochore Assembly and Function In Caenorhabditis Elegans
… independently by Aurora B at serine 634, and by CHK-1 at threonine T610. The research presented herein reveals that both phosphorylated forms of TLK-1 associate with the kinetochore during mitosis. Moreover, by systematic depletion of kinetochore proteins, I uncovered that pTLK-1 is <em>bona …
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The N-terminal Domain of the Y-box Binding Protein YB-1 Plays a Major Role in Cell Proliferation and Apoptosis
… disruption in one allele of chicken YB-1</p> <p>(Chk-Yb-1b) gene at its N-terminal domain resulted in multiple abnormalities in the heterozygous mutants, including slower growth rate, abnormal cell morphology, increased cell size, increased genomic DNA content and significant changes in levels of …
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On Partial Aborts and Reducing Validation Costs in Fault-tolerant Distributed Transactional Memory
… abort models in QR-DTM, called QR-CN and QR-CHK. We implemented these protocols and conducted experimental studies using macro-benchmarks(e.g., distributed versions of STAMP benchmark), and micro-benchmarks (e.g., distributed data structures). Our studies reveal that QR-CN improves throughput …
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Regulatory Mechanisms of Mitotic Catastrophe Induced by Doxorubicin
… by 500 nM doxorubicin was caused from ATM/Chk signaling pathways. Although caffeine abrogated G₂arrest both in p21+/+ and p21-/- cells, multinucleation was accelerated only in p21-/- cells. CONCLUSION: In part I, LD doxorubicin induces SLP in Huh-7 human hepatoma cells, and then those cells …