Global ETD Search
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Showing 1 to 20 of 25 for “"CHIKV"”.
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γδ T CELLS MEDIATE PROTECTIVE IMMUNE RESPONSES INDUCED BY EILV/CHIKV, A CHIMERA VACCINE CANDIDATE, AGAINST CHIKUNGUNYA INFECTION
Chikungunya virus (CHIKV) is a re-emerging virus that causes acute chikungunya fever, often accompanied by severe and persistent arthralgia, known as chronic CHIKV infection (CHIKD). Development of safe and effective vaccines against CHIKV infection and disease remains a high priority. Eilat virus, …
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Adaptation of Chikungunya virus to Aedes albopictus mosquitoes: The role of mutations in the E1 AND E2 glycoproteins
Chikungunya virus (CHIKV) is a positive sense single-stranded RNA virus in the family Togaviridae that between 2005 and 2007 caused its largest outbreak/epidemic in documented history, affecting parts of Africa, the Indian Ocean islands, India, and Europe. An unusual feature of this epidemic was …
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Evaluation of Chikungunya Virus Infectious Events in Aedes Albopictus LR and Aedes Aegypti WE Mosquito Vectors
… still not fully understood. Chikungunya virus (CHIKV) is an alphavirus transmitted by Aedes albopictus and Aedes aegypti mosquitoes in tropical areas of Africa, Asia, and the islands of the Indian Ocean. In 2007 and 2009, CHIKV was transmitted outside these tropical areas to cause localized …
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Characterization of the role of the innate immune system in the pathogenesis of chikungunya virus in mice
Chikungunya virus (CHIKV) is an alphavirus which causes a febrile illness in people that can induce a persistent and recurrent arthralgia. Recent outbreaks of CHIKV in tropical regions have caused millions of people debilitating illness. With no specific vaccine or anti-viral treatment, the …
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Production and Testing of a Novel Live-Attenuated Chikungunya Vaccine
… of a novel live-attenuated chikungunya virus (CHIKV) vaccine. To this end, multiple strategies were adapted from the IRES-based vaccine strategy first employed with VEEV vaccine strain, TC-83. The first strategy, CHIKV/IRESv1, was highly stable during cell culture passages in Vero cells, and …
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The Expression of Chikungunya Virus Envelope 2 Glycoprotein Variants in Nicotiana benthamiana for the Development of a Diagnostic Reagent
… The causative agent is the chikungunya virus (CHIKV), an arbovirus of the Alphavirus genus. CHIKV is responsible for the largest epidemic recorded for an Alphavirus, infecting an estimated 1.4 to 6 million patients worldwide. Furthermore, it has been recognised by the United States army as a …
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Cross-reactivity among alphaviruses provides insight into viral emergence and novel defense strategies
… Sindbis, chikungunya, and Mayaro viruses (SINV, CHIKV, and MAYV, respectively) present with an incapacitating polyarthralgia that can persist for years following initial infection. To date, the most effective means of controlling these arboviral infections is through mosquito control programs. …
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Translational Frontiers for Chikungunya Virus: New World Epidemic, New Strains, New Therapeutic Targets
Chikungunya virus (CHIKV) infection results in chikungunya fever (CHIKF), marked by sudden onset of high fever, rash, and debilitating polyarthritis and polyarthralgia, which can last for months to years. Despite the severe morbidity and impact on disability adjusted life-years, an FDA-approved …
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A Role for Interferon Stimulated Gene-15 (ISG15) During Chikungunya Virus Infection
… fever is caused by Chikungunya virus: CHIKV), an infectious disease that is characterized by severe joint and muscle pain in humans. The latest outbreak of CHIKV, which began in 2005, has affected millions of people across India, Singapore, and the Indian Ocean Island region. Type I …
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Evaluation of arthropod-borne virus recombination potential and phenotype: In vitro and in vivo analysis of flavivirus and alphavirus model systems
… evaluated various alphavirus (chikungunya virus (CHIKV) and Sindbis virus (SINV)) and flavivirus (yellow fever virus (YFV) 17D) recombinant crosses. Standard molecular cloning methodologies were used to generate CHIKV, SINV, and YFV 17D replicon/defective helper systems possessing …
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Análise de receptores tool-like e citocinas envolvidas na susceptibilidade à infecções virais
… pelos vírus da Dengue (DENV), Chikungunya (CHIKV) e Zika (ZIKV). A infecção pelo CHIKV causou grande impacto a saúde pública devido a presença de sintomas altamente debilitantes como, inflamações nas articulações que podem durar meses ou anos. A inflamação induzida pela infecção viral está …
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The Development of New Tools to Investigate Alphavirus Replication Kinetics
… nyong virus (ONNV) and chikungunya virus (CHIKV) in infected mosquito cells. We found that (-) strand viral RNAs persisted in invertebrate cells for up to 21 days after infection. We also found that significantly less (-) strand RNA was present in cells infected with opal variants of both …
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Análise dos níveis séricos de vitamina D em pacientes infectados por arbovírus
… no Nordeste do país. Neste período, os vírus CHIKV e ZIKV se disseminaram nesta região, mas o impacto destas infecções ainda não está esclarecido na população. Por outro lado, a sintomatologia da infecção por ZIKV e CHIKV se confundem em alguns momentos, levando a possíveis erros diagnósticos …
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Effective Strategies for Preventing and Mitigating Emerging Viruses
… zoonotic RNA viruses such as chikungunya virus (CHIKV) and SARS-CoV-2 posing significant threats to global health. Several environmental and evolutionary factors have fueled the emergence and spread of infection, creating a constant arms race against emerging pathogens. Current prevention and …
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The Biotechnological Applications of an Insect-Specific Alphavirus
… encephalitis (VEEV), as well as chikungunya (CHIKV) viruses. Despite its evolutionary relationship to these human pathogens, EILV is unable to replicate in vertebrate cells due to blocks at attachment/entry and RNA replication. We hypothesized that, using a chimeric-virus approach, EILV could …
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The use of insect cells to identify potent and selective inhibitors of the replication of the Dengue and Chikungunya viruses and unravel their molecular mechanism of action
… are no antiviral drugs available for DENV and CHIKV treatment and prevention. Moreover, vector control strategies have failed so far. Thus, the development of potent inhibitors for a broad spectrum of RNA viruses is urgently needed. We established and characterized a new embryonic insect cell …
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Intersecting Threats: Exploring Obesity's Impact on Viral Pathogenesis and Transmission
… like West Nile Virus (WNV), chikungunya virus (CHIKV) and Mayaro virus (MAYV) and reduce the vaccine efficacy for influenza and SARS-CoV-2. Obesity is associated with a chronic state of inflammation and dysregulated immune response which has been proposed to be one of the mechanisms driving the …
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Modulation of Alphaviruses by Small RNAs
… with the mosquito-borne chikungunya virus (CHIKV), our studies suggest these small RNAs have little biological relevance in combating virus infections. Thus, while the accumulation of virus-derived siRNAs is essential to the survival of mosquitoes infected with CHIKV, they appear to have …
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Freirean Codes: A Transformative Educational Tool for Community Empowerment and Arboviral Control in Kenya
… By June 2016, 1,792 cases of DENV and CHIKV had been reported. Entomological and water management surveys related to local knowledge and behaviors about mosquito-borne disease prevention were conducted. The data collected allowed the researchers to identify 40 households that fell into …
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