Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"CHD4"”.
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Dissecting the role of CHD4 in the NuRD and ChAHP complexes
CHD4 (chromodomain helicase DNA-binding protein 4) is a widely conserved ATP-dependent chromatin remodeler essential for early mammalian development. Although best known for its role in gene regulation as a core component of the NuRD complex, CHD4 is also found within the ChAHP complex, which …
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The Role of the Nucleosome Remodeling and Histone Deacetylase (NuRD) Complex in Fetal γ-Globin Expression
… a role in γ-globin gene silencing, and Mi2β (CHD4) is a critical component of NuRD complexes. In the studies presented in Chapter 2, we observed that the absence of MBD2 in a sickle cell mouse model leads to a decrease in the number of sickled cells observed in the peripheral blood, and …
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Locus-specific proteomics identifies novel repressors of Epstein-Barr virus reactivation
… complex PRC1 and the nucleosome remodeler CHD4. These proteins were found to independently bind the latent EBV genome and CRISPR-Cas9-mediated depletion of either of these components resulted in spontaneous lytic reactivation, confirming their role as repressors. My further experiments …