Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 42 for “"CGRP"”.
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Role of CGRP in the amygdala in pain-related synaptic plasticity and behavior
… high levels of calcitonin gene-related peptide (CGRP) are present in the CeA, most notably in the latero-capsular part (CeLC), which is now defined as the \"nociceptive amygdala\". The parabrachio-amygdaloid connection is essentially the exclusive source of CGRP in the CeA. The role of CGRP in …
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Comparing the efficacy of botulinum toxin and CGRP antagonists for chronic migraine prophylaxis
… and disability-affected life years. Botox and CGRP antagonists are two drugs used as prophylactic treatments for chronic migraine patients who have failed other medications in the past. However, there are currently no studies that have directly compared the two drugs and existing research …
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CGRP family of G protein-coupled receptors and their signalling in human cardiovascular cells
… (GPCRs), and one of their subclasses: The CGRP receptor family. These receptors are crucial for transducing information from the extracellular to intracellular space. While much pharmacological research has gone into understanding the signalling and function of GPCRs in recombinant systems, …
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Design, Synthesis and Pharmacological Characterization of Novel Calcitonin Gene-Related Peptide Receptor Antagonists
ABSTRACT|Human-a-calcitonin gene-related peptide (CGRP) is a 37 amino acid residue neuropeptide produced from tissue-specific alternative splicing of the primary RNA transcript of the calcitonin gene. CGRP is widely distributed throughout the central and peripheral nervous systems and is involved …
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Central Role Of CGRP And Protein Kinase A In Promoting Trigeminal Sensitization In An In Vivo Model Of Temporomandibular Joint Disorder
… neuropeptide calcitonin gene-related peptide (CGRP) in the joint capsule and upper spinal cord are implicated in the underlying pathology of TMJD. The cellular effects of CGRP are mediated by increases in the activity of the protein kinase A (PKA), a protein known to cause neuronal …
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Serum calcitonin gene-related peptide concentrations in the horse and their relationship to the Systemic Inflammatory response
… of both procalcitonin and its related molecule CGRP have been documented to increase in humans with SIRS, yet no literature exists as to the production or role of CGRP in equine patients with SIRS. This study showed that equine CGRP was produced in detectable quantities by healthy adult horses …
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Calcitonin Gene-Related Peptide Promotes Peripheral and Central Trigeminal Sensitization
… of trigeminal nociceptive neurons. Although CGRP is implicated in the development of central sensitization by stimulating glial activation via its receptor, the mechanism by which CGRP promotes and maintains sensitization of trigeminal nociceptive neurons is not well understood. The goal of …
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Effects of Neurotrophic Factors on Osteoblast Growth and Differentiation
… Since calcitonin gene-related peptide (CGRP) and Substance P (SP) are the most abundant neuropeptides present in sensory nerves in bone, the current studies were intended to test the hypothesis that these two neuropeptides may have direct effects on osteoblast growth, differentiation, …
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El péptido en relación con el gen de la calcitonina como potencial biomarcador de migraña crónica
… relacionado con el gen de la calcitonina (CGRP) en las terminales nerviosas como resultado de la activación del sistema trigémino-vascular. OBJETIVOS El objetivo de este estudio fue determinar la validez de CGRP en sangre periférica como posible biomarcador de MC. Además se pretende conocer …
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Calcitonin Gene-Related Peptide Promotes Wound Healing of Cornea
… process. Calcitonin gene-related peptide (CGRP), a 37-amino acid neuropeptide, is a biologically active protein that has many functions throughout the nervous system including promoting vasodilation and cell proliferation. Based on the expression of CGRP and its receptor, RAMP1, in adult …
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Efeito da desnervação periférica sobre o padrão de imunorreatividade ao GABA, neuropeptídeo Y, somatostatina e CGRP na medula espinal de rãs Rana catesbeiana
… peptídeo relacionado ao gene da calcitonina (CGRP), somatostatina (SOM) e ácido γ-aminobutírico (GABA) em medula espinal lombossacral de rãs Rana catesbeiana em condições basais e após a secção do nervo ciático. Para isso, foram utilizados animais adultos, de ambos os sexos, os quais foram …
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SEX DIFFERENCES IN GENE EXPRESSION AND PAIN-RELATED BEHAVIORS IN A PRECLINICAL MODEL OF MIGRAINE
… such as calcitonin gene related peptide (CGRP). A vasoactive neuropeptide, CGRP might contribute to the vasodilatory component of migraine, and to the pain associated with this condition as it is present in nociceptors, including those in the trigeminal ganglion that innervate cerebral …
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Functional Roles of A1-adrenergic Receptors in the Bovine Inferior Alveolar Artery: Regulation of Contraction and Activation of Extracellular Signal Regulated Kinase
… (ACH), calcitonin gene-related peptide (CGRP) and norepinephrine (NE) on vascular tone in the BIAA using functional measurements of contraction. 5-HT potently contracted BIAA rings with an BC50 = 0,81 ± 0.28 pM and was used to pre-contract rings sub-maximally for relaxation experiments. …
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Molecular Mechanisms by Which HSP90 Inhibition in the Spinal Cord Enhances Opioid Receptor Signaling
… AMPK colocalized with the neuropeptide CGRP and the neuronal marker NeuN, and EGFR colocalized with CGRP. We further used CRISPR gene editing to knockdown AMPK in CGRP neurons, which was sufficient to enhance opioid antinociception without HSP90 inhibition. When we knocked down EGFR in …
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Síntomas parasimpáticos craneales en pacientes con migraña crónica y correlación con biomarcadores
… péptido relacionado con el gen de calcitonina (CGRP), el péptido intestinal vasoactivo (VIP) y el polipéptido activador de adenilato ciclasa pituitaria (PACAP). Nuestro grupo de trabajo ha demostrado un aumento en los niveles plasmáticos del marcador parasimpático VIP en pacientes con MC, aunque …
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Neurochemical characterization of primary sensory neurons in a rat model of bortezomic-induced peripheral neuropathy
… neuropeptides calcitonin.gene-related.peptide (CGRP) and substance.P (SP) were studied in L4-L5 dorsal root ganglia (DRGs), spinal cord and sciatic nerve using western blot (WB), immunohistochemistry, and reverse transcriptase-polymerase chain reaction (RT-PCR). Behavioral measures, performed at …
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Effect of Intranasal Delivery of Carbon Dioxide on Trigeminal Ganglion Neurons: Inhibition of Neuron-Glia Gap Junction Communication and Neuropeptide Secretion
… Activation of trigeminal nerves, release of CGRP, and neuron-glia interactions through gap junctions in trigeminal ganglion are implicated in the pathology of migraine and allergic rhinosinusitis. The goal of this study was to determine whether administration of 100% CO2 to the nasal mucosa …
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The gastrointestinal effects of calcitonin and related peptides
… icatacalcin and calcitonin gene-related peptide (CGRP) were found to be very different. Whilst calcitonin was shown to have both hypocalcaemic and anti-ulcerogenic actions, katacalcin demonstrated only an hypocalcaemic action, and CGRP showed neither of these actions. The results indicate that …
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Secretomotor substances in the rat lacrimal gland: Immunocytochemical functional and ligand binding studies
… P (SP)-, calcitonin gene-related peptide (CGRP)-, tyrosine hydroxylase (TH)- and the phosphoprotein B-SO- immunoreactive (IR) nerve fibres. 13- 50-lit was distributed around acini, blood vessels and ducts, in a similar manner to VIP, SP and CGRP; though there was less VIP-IR nerves …
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