Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"CGNS"”.
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Neuroprotective Effects of Anthocyanins on Neuronal Death Induced by Inhibition of Bcl-2 and Oxidative Stress
… cultures of rat cerebellar granule neurons (CGNs). Anthocyanins are natural antioxidants whose neuroprotective potential has yet to be examined in detail. Kuromanin and callistephin are anthocyanins derived from black rice and strawberries, respectively. Glutathione (GSH)-sensitive MOS and …
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Rho GTPases in Neuronal Apoptosis and Neurodegeneration
… (ERK)1/2 cascade which functions in healthy CGNs to promote the degradation of the pro-apoptotic Bcl-2 homology-3 domain (BH3)-only protein Bim while also repressing a pro-apoptotic Janus kinase (JAK)/Signal transducer and activator of transcription (STAT) signaling cascade. Here, we reveal …
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Postmitotic Dynamics in Chromatin Modification and Regulatory Topology Underlie Cerebellar Granule Maturation
… maturation of cerebellar granule neurons (CGNs) requires dynamic changes in the genomic distribution of histone H3 lysine 27 trimethylation (H3K27me3), demonstrating a causal function for this chromatin modification in gene regulation beyond its canonical role in cell fate specification. …
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Investigating xanthine oxidase toxicity models in cultured cerebellar granule neurons
… primary cultures of cerebellar granule neurons (CGNs) were used. In the beginning, some problems were encountered with CGNs. The main problem was the immediate damage induced to the neurons (including those in the control groups) at the intervention/experiments day (i.e. day 8 or 9 after plating) …
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Alkyladenine DNA glycosylase (Aag)-dependent cell-specific responses to alkylating agents
… progenitors and cerebellar granule neurons (CGNs) where Aag' cells are resistant to MMS induced killing compared to WT. In this study, we investigated how Aag can cause cell-specific responses to alkylating agents. We generated new WT, Aag-/-, and Aag overexpressing (mAagTg) 129 and C57B1/6 …