Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 49 for “"CGH"”.
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Hidden Markov Model inference copy number change in array-CGH data
… based competitive genomic hybridization (array-CGH) has become available as a powerful approach for genome-wide detection of DNA copy number changes. Array-CGH assesses DNA copy number in tumor samples through competitive hybridization on microarrays containing probes for thousands of genes. The …
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Comparative analysis of algorithms for identifying copy number variation in array CGH data
… for identifying copy number variation in array CGH data. Circular Binary segmentation (CBS), CGH segmentation, Price —Smith—Waterman algorithm (the three algorithms are a part of ADaCGH tool) and Cluster Along Chromosome (CLAC) which is not publicly available were studied and used for the …
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Molekular-zytogenetische Untersuchungen und Expressionsanalysen des Multiplen Myeloms
Durch die Kombination von SKY-, Array-CGH-, und Expressionsnanalysen wurden ausgewählte MM-Zelllinien auf Aberrationen hin untersucht und diese genauer analysiert. 32 Myelom-Patienten wurden mittels Array-CGH-Analyse untersucht und aufgrund ihrer Aberrationen und der klinischen Daten durch eine …
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Optimisation of Phase-Only Computer-Generated Holograms
… of existing Computer-Generated Holography (CGH) methods, which often involve trade-offs between computational efficiency and reconstruction quality. This thesis tackles these challenges through developing novel algorithmic approaches aimed at overcoming the obstacles that prevent the …
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The pathogenesis of classical Hodgkin lymphoma : investigation of possible viral pathogens and recurrent chromosomal imbalances
… (i.e. array-comparative genomic hybridisation (CGH) are overcoming these difficulties. To investigate a potential candidate virus, DNA samples from cHL biopsies were screened for the measles virus (MV) and polyomaviruses (PyV), using immunohistochemistry and highly sensitive PCR assays. …
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Improving the computation efficiency for computer-generated holography
… industry. Computer-generated holography (CGH) based picture generation unit is a promising and viable technology. Unlike other display counterparts where light intensity modulation is being used, CGH can modulate the phase of the incoming light and form an image via interference. This …
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High resolution DNA copy number analysis of constitutional chromosomal aberrations in human genomic disorders
… array comparative genomic hybridization (array CGH), allows the genome wide screening for submicroscopic aberrations in one single experiment. Array CGH uses reporter DNA molecules more or less evenly spread throughout the entire genome which are spotted or synthesized in an array on a glass …
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Chromosomale Veränderungen von Hirnmetastasen klarzelliger Nierenzellkarzinome
… klarzelliger Nierenzellkarzinome mittels CGH untersucht und mit CGH-Ergebnissen von Primärtumoren des klarzelligen Typs verglichen. Hirnmetastasen klarzelliger Nierenzellkarzinome zeigen als herausragende Veränderungen Verluste auf den Chromosomen 3p und 9 sowie Zugewinne auf den …
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Neue molekularzytogenetische Strategien für die Analyse seltener Zellen
… des veröffentlichten Protokolls zur Einzelzell CGH (C. Klein et al. 1999; N. Stöcklein et al.2002) war das zweite Ziel der Arbeit. Diese Optimierung war notwendig, weil sich das ursprünglich publizierte Protokoll als Artefakt anfällig herausstellte. Durch die in dieser Arbeit beschriebenen …
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Geophysical and Geochemical Constraints On the Geodynamic Origin of the Vrancea Seismogenic Zone Romania
… the Calimani, Gurghiu, and Harghita Mountains (CGH) have been reinterpreted in light of the seismic data which does not advocate the subduction of oceanic lithosphere. CGH rocks exhibit a compositional range from basalt to rhyolite, many with high-Mg# (Mg/Mg+Fe > 0.60), high-Sr (>1000 ppm), and …
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Developing and Optimizing Conditions for Single Cell Genetic Analysis
… use in array comparative genomic hybridization (CGH) to determine chromosome complement. Sporadic MDA results occurred at the single cell level; larger cell quantities consistently amplified. MDA can generate sufficient quantities of DNA for array CGH. Preliminary results show promise; further …
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Media Production for Computer-Generated Holography
Computer Generated Holography (CGH) is an immersive next-generation display technology with significant potential. It is the only technique that allows the reconstruction of true three-dimensional imagery while not compromising display resolution - achieved through the diffraction and interference …
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Genetic analysis of squamous cell carcinoma of the head and neck
… technique of comparative genomic hybridisation (CGH), and the clinical applications of such data. Firstly, the technique was optimised and initially applied to specimens of primary HNSCC and surrounding uninvolved mucosa from 19 patients in order to investigate the phenomenon of 'field …
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Comparative analysis of Cronobactor sp. with respect to genomic diversity and physiology
… (131 kb). Comparative genomic hybridization (CGH) was undertaken on five C. sakazakii strains, and representatives of four other Cronobacter species. CGH highlighted 15 clusters of genes that were divergent or absent in more than half of the tested strains.
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Genome sequence of the hyperinvasive Campylobacter jejuni strains
… performed by comparative genomic hybridization (CGH) against four low invasive C. jejuni strains. A group of 67 genes were identified as being present or highly divergent/absent in the hyperinvasive versus low invasive C. jejuni strains. Of these, nine genes were present and six genes were highly …
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Advanced Algorithmic Approaches for Improving Image Quality in 2D and 3D Holographic Displays
… descent method is introduced to phase-only CGH optimisation. Contemporary image quality metrics (IQMs) considering human visual systems are employed as loss functions to improve the reconstructed image quality. Extensive objective and subjective assessment of experimentally reconstructed …
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Identifying the Genetic Factors in Natural Genome Backgrounds That May Modulate Phenotypic Outcomes in C. elegans
… genes– mat-1 (metaphase-to-anaphase defect) and cgh-1 (conserved germline helicase) in Caenorhabditis elegans, using natural isolate backgrounds. Both, cgh-1 and mat-1, contain hypomorphic temperature-sensitive alleles that allow propagation at a permissive temperature (15°C) while causing …
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Prognostischer Zusammenhang zwischen Mutationen des KIT- und PDGFRA-Gens und molekularzytogenetischen Veränderungen gastrointestinaler Stromatumoren
… einer komparativen genomischen Hybridisierung (CGH) mit den Ergebnissen einer Mutationsanalyse des KIT- bzw. PDGFRA-Gens.METHODEN: 64 Tumorproben von GIST aus dem Zeitraum von 1993 - 2005 wurden mittels CGH auf chromosomale Imbalanzen (CI) untersucht. Zusätzlich wurde eine Mutationsanalyse des …
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Interactions of Chitin and Lignin Thin Films with Other Molecules
… films increased. Almost all the CG-DHP or CGH-DHP films were degraded when the percentage of the C-alcohol in the polymerization feed was ≥ 75% and ≥ 60% for CG-DHP and CGH-DHP, respectively.
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Análisis genético de paragangliomas de cabeza y cuello
… cromosómicas mediante la técnica de microarray-CGH, estudiándose además las mutaciones en los genes SDHB, SDHC, SDHD, RET Y VHL en pacientes que presentaban PGL de cabeza y cuello. Una vez realizado el análisis mutacional de todos los genes implicados en los PGLs familiares y establecida la …
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