Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 7 of 7 for “"CFTR modulators"”.
-
Role of the Lipid Environment and Cholesterol Content in the Function of CFTR Modulators
… Fibrosis Transmembrane Conductance Regulator (CFTR). Despite CFTR being a protein located in epithelial cell membranes, it has not been established whether the membrane surrounding CFTR plays a role in the function of the recently-discovered CFTR modulators. In concert with a variety of …
-
Small molecule channels increase anion secretion and host defenses in cystic fibrosis airway epithelia: mechanistic studies and initial clinical translation
… fibrosis transmembrane conductance regulator (CFTR) anion channel. Loss of CFTR-mediated HCO3- and Cl- secretion to the airway surface liquid (ASL) compromises airway host defenses in people with CF and contributes to the chronic bacterial infection and airway inflammation that characterize CF …
-
LIPID-BASED APPROACHES TO OPTIMIZE THE EFFECTIVENESS OF INNOVATIVE DRUG MODULATORS IN CYSTIC FIBROSIS
… Fibrosis Transmembrane Conductance Regulator (CFTR) gene. This gene encodes a chloride-conducting transmembrane channel crucial for ion transport across epithelial cells. CFTR mutations lead to impaired expression and function of the channel, causing disrupted chloride ion transport in …
-
Defining a role for the cystic fibrosis transmembrane conductance regulator in the heart
… ago we have come to understand that loss of CFTR (cystic fibrosis transmembrane conductance regulator) function affects numerous tissues and systems throughout the body. Concerning the heart, right ventricular dysfunction secondary to pulmonary abnormalities has long been recognized. However, …
-
Antifungal Immune Responses and Inflammation in the Cystic Fibrosis Airways
… (the Cystic Fibrosis Transmembrane Regulator or CFTR), a chloride transporter found in both epithelial and immune cells, results in persistent infections and inflammation in the airways. It has been shown that Aspergillus fumigatus frequently infects the airways of people with CF and contributes …
-
Antifungal Immune Responses and Inflammation in the Cystic Fibrosis Airways
… (the Cystic Fibrosis Transmembrane Regulator or CFTR), a chloride transporter found in both epithelial and immune cells, results in persistent infections and inflammation in the airways. It has been shown that Aspergillus fumigatus frequently infects the airways of people with CF and contributes …
-
An investigation of the cellular effects of novel agents and multi-drug combinations in cystic fibrosis
… fibrosis transmembrane conductance regulator (CFTR) chloride secretion and overactive epithelial sodium channels (ENaC), which leads to hyper-absorption of Na+ and water from the airway lumen. The resulting thickened secretions and airway plugging give rise to devastating cycles of chronic …