Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"CELF1"”.
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Regulation and function of the RNA-binding protein CELF1
… binding protein CUGBP1 and Etr3 Like Factor 1 (CELF1). CELF1 binds to a GU-rich element (GRE) harbored in target transcripts and promotes their rapid decay through the recruitment of RNA decay enzymes. The work presented in this thesis focused on elucidating the function and regulation of CELF1 …
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CELF1, PTBP1, and RBFOX2-mediated alternative splicing regulation in cardiovascular diseases
… dysregulation of the RNA binding proteins (RBPs) CELF1, PTBP1, and RBFOX2 contribute to AS changes. Utilizing genome-wide approaches, we identified extensive changes in AS patterns in T1D mouse hearts. We discovered that many aberrantly spliced genes in T1D hearts have CELF1 and PTBP1 binding …
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miR-322/503 Cluster Drives Cardiac Differentiation by Inhibiting CUG-binding Protein 1
… splicing/decay factor, CUG-binding protein 1 (Celf1), which is also known for a role in myotonic dystrophy pathogenesis. The evidences include: (i) miR-322 and miR-503 had a shared target site at the 3’UTR of Celf1; (ii) expression patterns of miR-322/503 and Celf1 were mutually exclusive, with …
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Mechanisms of Dysregulated Alternative Splicing in Cardiac and Skeletal Muscle under Diabetic Conditions
… and controls RNA-binding proteins (RBPs) CELF1 and RBFOX2 that are involved in developmentally regulated AS in the heart. Since PKC is chronically activated in diabetes, we hypothesized that aberrant PKC activity alters CELF1 and RBFOX2 and disrupts AS. To test this hypothesis, we …
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Understanding regulation of mRNA by RNA binding proteins
… splicing factors RBFOX2, MBNL1 and CELF1/CUGBP1. For each factor, the canonical motifs are recovered as well as additional near-optimal binding motifs. RNA secondary structure inhibits binding of RBFOX2 and CELF1, while MBNL1 favors unpaired Us but tolerates C/G pairing in …
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New Insights into the Regulatory Network Controlling Neuroblast Migration in C. elegans
… role of the putative RNA-binding protein ETR-1/CELF1 in Q neuroblast migration. The gene etr-1 encodes for an RNA-binding protein most similar to CELF1 in mammalian systems. CELF1 is part of the CELF-family of proteins, a large family of RNA-binding proteins that process messenger RNA. We show …
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Identification of Functional Variants in Alzheimer's Disease-Associated Genes
… metabolism. We found rs7937331, within the CELF1 fine-mapping region, tags the same signal as the IGAP top SNP (rs62003531) and is significantly associated with CSF Aβ<sub>42</sub> levels and AD risk. Additionally, rs62003531, located in the intronic region of FERMT2, tags the same …
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Protein-dependent prediction of messenger RNA binding using Support Vector Machines
… Starting from a case study, done with protein CELF1, we extend our approach and propose three methods to predict whether an RNA strand can be bound by a particular RNA-binding protein. The methods use support vector machines and different features based on the sequence (method Oli), the motif …
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Characterisation of Tau splicing factors in Alzheimer’s disease
… the expression levels of CELF proteins (CELF1, CELF3 and CELF4) and SR proteins (SC35, SRp40, and SRp55) in AD cases with (+) and without (-) TDP-43 inclusions compared to aged-matched controls.<br/><br/><br/>Tau E10 alternative splicing pattern analysis revealed that tau4R was increased …
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Global analysis of mRNA decay rates and RNA-binding specificity reveals novel roles for CUGBP1 and PARN deadenylase in muscle cells
Type I Myotonic Dystrophy (DM1) is characterized by myotonia, cardiac conduction defects, muscle wasting, and insulin resistance. In patient muscle cells expression and function of the RNA-binding proteins CUGBP1 and MBNL1 are disrupted, resulting in altered mRNA metabolism at the levels of …