Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 80 for “"CED"”.
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The Pro-Apoptotic Function of CED-9 Requires a CED-9-CED-4 Interaction
… apoptosis is inhibited by the BCL-2 homolog CED-9. In addition to its canonical anti-apoptotic role, CED-9 possesses an apparent proapoptotic function, because reduction in CED-9 function can result in decreased cell death – e.g., a ced-9(lf) allele enhances the partial cell-death defect of …
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Genetic and molecular studies of ced-5 and ced-7, two genes required for cell-corpse engulfment in C. elegans
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1998.
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Genetic and molecular analysis of the C.elegans cell survival gene ced-9
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1994.
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C. elegans apoptosis : CED-4 translocation and involvement in a model of mucolipidosis type IV human lysosomal storage disorder
… Caenorhabditis elegans. We have found that the CED-9 protein, an anti-apoptotic member of the Bcl-2 family of apoptotic regulators, is required for the sequestering of the CED-4 cell-death activator to mitochondria. In the absence of CED-9 in C. elegans embryos, we found that CED-4 protein …
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Phagocytosis promotes programmed cell death and is controlled by Rac signaling pathway in C. elegans
… Caenorhabditis elegans, four genes, egl-1, ced-9, ced-4, and ced-3, control the execution of cell death and define a molecular pathway for cell death conserved in humans. Seven genes control the engulfment of cell deaths and define two partially redundant pathways: ced-1, ced-6, and ced-7 in …
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The regulation of programmed and pathological cell death in C. elegans
… In the nematode C. elegans, four genes, egl-1, ced-9, ced-4, and ced-3, constitute the core pathway acting in all somatic programmed cell deaths. This pathway is evolutionarily conserved in humans. The BH3-only protein EGL-1 is transcriptionally upregulated in cells fated to undergo programmed …
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Butyrophilin family genes as putative coeliac disease risk loci
Coeliac disease (CeD) is a T-cell mediated autoimmune enteropathy (1). CeD is triggered by the consumption of gluten, the collective name of a group of proteins present in wheat, rye, and barley (1, 2). The prevalence of CeD in the United Kingdom (UK) is around 1% and the number of new CeD …
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Genetic and Molecular Characterization of Programmed Cell Death in the C.elegans Tail-Spike Cell
… cell-specific death. EGL-1 protein inhibits the CED-9/Bcl-2 protein, resulting in release of the caspase activator CED-4/Apaf-1. Subsequent activation of CED-3 caspase by CED-4 leads to cell death. But despite the important role of egl-1 transcription in promoting CED-3 activity in cells destined …
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Organizing community economic development in an inner-city neighbourhood: a case study
… on organizing community economic development (CED) in the inner-city neighbourhood of Mount Pleasant, in Vancouver. Participant-observation research techniques, combining the roles of organizer and researcher, were used in this exploratory study. The ethnic and cultural diversity of this …
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Thermotherapeutic enhancement of infusate distribution during convection enhanced delivery in the brain using fiber-optic microneedle devices
… median survival of 13.4 months. Convection enhanced delivery (CED) has shown promise for the treatment of GBM by allowing intratumoral delivery of therapeutics, bypassing the blood brain barrier. A fiberoptic microneedle device (FMD) CED catheter enables simultaneous delivery of laser energy and …
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Vergleich der Genexpression im entzündlichen Kolonepithel und im kolorektalen Karzinom im Hinblick auf das erhöhte Tumorrisiko bei chronisch entzündlichen Darmerkrankungen
… im Kolonepithel von Menschen mit einer CED zugrunde liegen. Um die Gefahr der Tumorentstehung rechtzeitig erkennen zu können, sollen frühe Marker gefunden werden, die die Bereitschaft, einen Tumor zu entwickeln, noch vor Entstehen seiner Vorstufen anzeigen. Dazu wird mit Hilfe der …
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DRE-1/FBXO11, a Conserved F Box Protein, Regulates Apoptosis in C. elegans and is Mutated in Human Lymphoma
… that the core machinery, made up of the egl-1, ced-9, ced-4 and ced-3 genes, is conserved across metazoans, and their homologues are crucial for such diseases as cancer, neurodegeneration and autoimmunity. We used the C. elegans tail-spike cell as a model to uncover dre-1/FBXO11 as a conserved …
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Genetic and molecular studies of cell-autonomous execution during programmed cell death in C. elegans
… of cysteine proteases. The discovery of the CED-3 caspase in C. elegans led to the paradigm that caspase cleavage of substrates drives cell death and promotes engulfment. While many caspase substrates have been identified, it is not well understood how caspase substrates act to promote cell …
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Untersuchung Nahrungsmittel-reaktiver CD4+ T-Zellen im gesunden Zustand und in Chronisch Entzündlichen Darmerkrankungen
… mit Chronisch Entzündlichen Darmerkrankungen (CED) charakterisiert, um so das Wissen um den bislang nicht vollständig verstandenen Einfluss der Ernährung auf CED zu erweitern. Methodik: Die Antigen-reaktive T-Zell-Anreicherung ermöglicht die Detektion seltener Antigen-reaktiver T-Zellen in …
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Kurz-, mittel- und langfristige Effekte einer Schulung für Patienten mit chronisch entzündlichen Darmerkrankungen auf krankheitsbezogene Ängste und Gesundheitskompetenzen
… mit chronisch entzündlichen Darmerkrankungen (CED) leiden unter vielfältigen körperlichen und psychosozialen Einschränkungen. Wie auch bei anderen chronischen Erkrankungen könnten Patientenschulungen ihr psychisches Befinden verbessern (z.B. De Ridder & Schreurs, 2001; Faller, Reusch & Meng, …
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GICEDCAM: A Geospatial Internet of Things Framework for Complex Event Detection in Camera Streams
Complex Event Detection (CED) in video streams is increasingly important for surveillance, safety monitoring, and real-time situational awareness. However, detecting complex events remains challenging due to missed object detections, unreliable spatial–temporal relationships, and the high …
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Corporate Environmental Disclosure:A Case from the Libyan Construction Industry
… and kind of corporate environmental disclosure (CED) within annual reports and its development over time, as well as the effect of external and internal factors on the environmental disclosure.The main aim of this study is to explore current disclosure of environmental issues carried out by …
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A Model for Studying Vasogenic Brain Edema
Convection-enhanced delivery (CED) is a proven method for targeted drug delivery to the brain that circumvents the blood-brain barrier (BBB). Little study has been conducted in understanding CED in pathological brain states. This is of importance when dealing with chemotherapeutic agent delivery to …
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The status of Xhosa and communicative competence in Cape Education Department schools
… 10 pupils in Cape Education Department Schools (CED) sought to verify or negate two central concerns which surf aced in a pilot study of five Western Cape schools. This thesis contends that little has changed throughout South Africa's colonial and apartheid history with regard to the status of …
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