Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"CEBPA"”.
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Molecular signatures underlying the tumourigenic transformation in a CEBPA mutated model of leukaemia
… and bio- logical heterogeneity of leukaemia. The CEBPA gene is found to be commonly mutated in AML patients. Nevertheless, questions remain in terms of the mechanism of leukaemic transformation and diagnostic implications. Mutations in CEBPA are thought to arise early in tumourigenesis as patients …
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The Role of the Transcription Factor CEBPA in Regulating Lung Alveolar Type 2 Cell Fate In Vivo
… critical role of the transcription factor (TF) CEBPA, specific to lung alveolar type 2 (AT2) cells, in modulating AT2 cell plasticity within the mouse lung. We demonstrate that CEBPA constrains AT2 cell plasticity by promoting the AT2 differentiation program and recruiting the lineage-specific …
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Deciphering pre-leukaemic dysregulation caused by mutant C/EBPα at the level of the single cell
… factors (TFs) in lineage specification, and the CEBPA gene has been identified as an early mutation in acute myeloid leukaemia (AML). N321D is a mutation affecting the leucine zipper domain of C/EBPα which has previously generated an aggressive AML phenotype in a mouse model. The first objective …
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Deciphering the Pathogenesis of Acute Myeloid Leukemia
… this, knockin mouse strains harboring different Cebpa mutations and Flt3-ITD were used to generate an AML mouse model. This model demonstrated a block at the transition from pGMP to GMP due to disrupted C/EBPα function. The cooperative effect of FLT3-ITD is composed of enhancing the generation of …
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Basi molecolari della differente risposta delle cellule alpha e beta del pancreas di mammifero all apoptosi mediata da citochine: implicazioni patogenetiche nel Diabete Mellito
… bTC1 [Barbagallo D, Condorelli AG, Piro S et al. CEBPA exerts a specific and biologically important proapoptotic role in pancreatic beta cells through its downstream network targets. Mol Biol Cell, 2014].
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Effects of weaning age and maternal nutrition on gene expression of longissimus muscle of beef steers
… the expression of PPARG, other adipogenic (CEBPA, ZFP423) and lipogenic (THRSP, SREBF1, INSIG1) activators, and several enzymes (FASN, SCD, ELOVL6, PCK1, DGAT2) that participate in the process of IMF increased gradually to a peak between 96 and 167 days on treatment. Steers in NW did not …
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Effects of maternal supplementation of trace minerals and fatty acids on beef progeny
… (P = 0.09) for SFA/MUFA steers to have greater CEBPA mRNA expression than PUFA2, with CRN being intermediate and not different from the other two treatments. No differences (P ≥ 0.11) were detected for mRNA expression of other selected genes during the late finishing phase. Thus, maternal …
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Cellular and Molecular Mechanisms Governing Intramuscular Fat Development and Growth in Cattle
… expression of adipocyte markers (PPARG, CEBPA, FABP4, ADIPOQ) in cells differentiated from these clones. Four single-cell clones derived from IMF preadipocytes and four from SF preadipocytes, each isolated from a single steer, were selected for further characterization. Transcriptomic …
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Effects of dietary fat and protein from corn coproducts on growth, carcass characteristics, ruminal metabolism, and genomic regulation of marbling development in early-weaned beef cattle
… 0.01) occurred for the expression of ADIPOR2 and CEBPA resulting in a carryover effect wherein low fat diets fed during the growing phase increased expression of both genes at the end of the finishing phase (d 224). Carcasses from cattle fed control during the growing phase tended (P = 0.09) to …