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Showing 1 to 6 of 6 for “"CEACAM1"”.
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Identifizierung und Charakterisierung neuer intrazellulärer Bindungspartner von CEACAM1-L und deren Einfluss auf CEACAM1-L-vermittelte zelluläre Funktionen
… neuer intrazellulärer Interaktionspartner von CEACAM1-L identifiziert. Um die funktionelle Auswirkung der Interaktion von CEACAM1-L und Filamin A zu untersuchen, wurde ein humanes Melanom- Zellsystem etabliert, dass die Filamin A- und CEACAM1-L-negativen wt-M2-Zellen und die daraus durch …
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Characterization of CEACAM1 Spatial Distribution, Self-association and Dynamics using High-resolution Microscopy Techniques
… and infection. There is growing evidence that CEACAM1 isoforms regulate the cellular response to CEACAM1-mediated interactions between various cell types. Reinforcing this point, given its potential as a tumour suppressor and immunomodulator, CEACAM1 is being targeted for clinical development. …
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Proteomics based analysis of interactions between CEA cell adhesion molecule 1 (CEACAM1) and intracellular proteins in transfected tumor cells
CEA Cell Adhesion Molecule 1 (CEACAM1), a type 1 transmembrane protein belonging to the CEA gene family, is alternatively spliced to produce four major isoforms with a long (CEACAM1-L) or a short cytoplasmic domain (CEACAM1-S). Immunoprecipitations using the murine adenocarcinoma MC38 cell line …
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An immunoproteomic approach to identifying cancer-associated autoantibody biomarkers
… Combinatorial ROC analysis indicates that CEACAM1 and GRWD1 as the top autoantigen combination for CRC diagnosis, together producing sensitivity-, and specificity-, and AUC-values of 1.00, 0.77 and 0.94, respectively. Furthermore, other top autoantigens, including COL6A1, THEG and CEACAM7, …
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CEACAM3: ein neuartiger phagozytischer Rezeptor der angeborenen Immunantwort zur Erkennung human-spezifischer Pathogene
… dosisabhängig, wohingegen die Blockade der CEACAM1- bzw. CEACAM6-vermittelten Internalisierung der Gonokokken durch Nystatin keine Auswirkungen zeigt. Auch die Proteintransduktion der dominant-negativen Version von Vav (TAT-Vav-dn) bzw. Rac (TAT-Rac-dn) in primäre Granulozyten interferierte …
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Determinants of Immunity against the Meningococcus
… nasal infection, wherein expression of human CEACAM1 allows N. meningitidis to colonize the murine nose. I reveal that protection against nasal colonization is absolutely reliant on B cells and neutrophils, suggesting that opsonophagocytosis plays a major role in prevention of nasal …