Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 31 for “"CDRs"”.
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Generation of chickenized 3D8 scFv antibody from mouse monoclonal anti-DNA antibody by CDRs-grafting
… developed a chickenized antibody of 3D8 scFv by CDRs (complementarity-derermining regions) grafting. A chickenized 3D8 scFv variant (CK) was generated by transferring six CDRs of 3D8 scFv between FRs (framework regions) of a chicken antibody which reveals high solubility and expression level in …
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Validation of the Ottawa Ankle Rules for Acute Foot and Ankle Injuries
… were developed as clinical decision rules (CDRs) for the emergency department setting. However, these CDRs have not been validated as an acute clinical evaluation tool. Currently, there are no sport-specific CDRs relating to acute ankle injuries. Objective: The objectives of this study were: …
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Structure, Function and Engineering of Peptide -Mhc Binding Receptors
… TCR variants. In contrast, other CDRs (CDR1, and especially CDR2) of the TCR are typically located over the MHC helices and thus may not be positioned to interact directly with peptide. Mutations in these CDRs might be expected to yield high-affinity but reduced peptide specificity …
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Effect of disruption of 3D8 complementarity-determining regions on properties of 3D8 antibody
… or deletion of amino acids within or near CDRs (complementarity-determining regions) in antibodies have been utilized to improve antigen-binding affinity and/or stability. However, little is reported about functional consequence by the disruption of whole amino acid sequence in CDRs of an …
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Clinical presentation and diagnostic work up of suspected pulmonary embolism in a district hospital emergency centre serving a high HIV/TB burden population
… improved by the use of Clinical decision rules (CDRs) and CT Pulmonary Angiography (CTPA) in high-income countries. Currently used CDRs have not been validated in the South African environment, where HIV and TB are highly prevalent. Both conditions are known to induce a hyper-coagulable state. …
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Improving Depressive Symptom Measurement in Adolescents: A Psychometric Evaluation of the Quick Inventory of Depressive Symptomatology, Adolescent Verison
… the Children's Depression Rating Scale-Revised (CDRS-R). Classical Test Theory (CTT) analysis found all three QIDS-A17 measures to show strong internal consistency and correlate significantly to the CDRS-R, although the CDRS-R was the most reliable. Factor and parallel analysis found all four …
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Hard hitting facts on childhood head trauma: an epidemiological analysis
… various Clinical Decision Rules (CDRs) have been established in High Income Countries. These protocols, including the need for CT scan might differ in a Medium/Low Income setting. Methodology: This is a prospective, single centre cohort study. Data were collected over an 18-month …
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Residual Symptoms in Pediatric Depression after Acute Pharmacological Treatment
… subgroup of responders, dysthymic disorder and CDRS-R total baseline score were found to be predictive of responders who remit. Residual symptoms were found to be present in both the fluoxetine and placebo treatment group responders in high frequency. Finally, using the CDRS-R individual item …
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Fostering personal resilience in the Royal Air Force: a study of Force Development and Adventurous Personal Development Training
… research (Connor Davidson Resilience Scale (CDRS)-25 questionnaire and focus groups) confirmed perceived resilience development for psychological, physical, social and spiritual resilience factors identified within the CDRS-25. Evidence from follow-up focus groups suggests that resilience is …
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AN EXAMINATION OF THE RELATIONSHIP BETWEEN ATTACHMENT STYLE AND BODY IMAGE IN ADOLESCENT GIRLS: A FOCUS ON THE MOTHER-DAUGHTER RELATIONSHIP
… IPPA), body image (Contour Drawing Rating Scale, CDRS), and a researcher created demographic questionnaire. The IPPA and CDRS had two versions, one asking participants to answer based on their current age and the other asking them to report about when they were 11 years old. Attachment was …
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Structural studies of the human polymeric immunoglobulin receptor
… in the complementarity determining regions (CDRs). CDR1, the primary determinant in dimeric IgA binding, contains a single helical turn. CDR2, the main determinant in binding to pIgM is very short and contains a potentially critical glutamic acid involved in pIgM binding. CDR3 points away …
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Engineering intracellular antibody libraries
… of variable complementarity determining regions (CDRs), the number amino acids used to diversify CDRs, and configuration of the structure. How the parameters affect the binding capacity will be tested using the yeast two hybrid assay against five different protein domains. Eight scFv libraries …
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Does Deliberation Make Better Citizens? Examining the Case of Community Conflict Mediation
… at Community Dispute Resolution organizations (CDRs). I study this case empirically through in-depth interviewing and observation at two CDRs in Toronto.</p> <p>I find limited evidence that participation in deliberation in this context can strengthen the efficacy or clarify the interests of …
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The Impact of Trauma History on Acute Treatment Outcomes in Pediatric Major Depressive Disorder
… the Children’s Depressive Rating Scale-Revised (CDRS-R) and remission status, defined as a score of ≤ 28 on CDRS-R and a Clinical Global Impressions (CGI) Improvement score of 1 or 2. Abuse history was associated with older age, older age of depression onset, longer length of illness, and …
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Analysis of ATM Call Detail Records and Recommendations for Standards
… a toolkit to collect ATM Call Detail Records (CDRs) from two types of ATM switches from IBM and FORE Systems. Data records collected by the toolkit can then be used to assess network resource utilization and traffic characteristics with the objective of predicting future needs, making proper …
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Statistical Analysis of ATM Call Detail Records
… In this research, Call Detail Records (CDRs) captured from a ¡§live¡¨ ATM network were successfully classified into three traffic categories. The traffic categories correspond to three different video speeds (1152 kbps, 768 kbps, and 384 kbps) in the network. Further statistical …
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Balancing utility and privacy of high-dimensional datasets : mobile phone metadata
… on a large dataset of mobile phone records (CDRs), where results empirically showed ordinal equivalence among unicity measures and information distance measures EM-disclosure and KL-disclosure. Advantages of the proposed framework are highlighted, and future research avenues identified. We …
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Characterization of Variable Region Structures and Antigen-Binding Properties of OxLDL-Specific Human Monoclonal Antibody Isolated from PBMC and Atherotic Plaques of Atherosclerosis Patients
… of replacement-to-silent mutation (R/S) in the CDRs was higher than those in the FRs of most of VH and VL; Many positively charged amino acids occurs in the CDRs of VH and VL of the antibodies. Comparison of the genes of Fabs with their germline counterparts revealed that overall similarity of …
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Estimating the presence of people in buildings using Call Detail Records
… this study explores how Call Detail Records (CDRs), a highly ubiquitous dataset, can be leveraged to create models that can reproduce mobility patterns observed from time consuming, capital-intensive and infrequent travel surveys. While mechanisms have been proposed for reproducing particular …
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Entwicklung influenzabindender Peptide für die Biosensorik
… Regionen (complementarity determining regions, CDRs) der schweren Kette eines monoklonalen Hämagglutinin-bindenden Antikörpers wurden drei lineare Peptide abgeleitet. Die Bindungseigenschaften der drei Peptide wurden experimentell mittels Oberflächenplasmonenresonanzspektroskopie untersucht. Es …
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