Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 5 of 5 for “"CDK7"”.
-
Small-molecule inhibition of general transcriptional regulators in cancer
… inhibiting a general transcriptional regulator, CDK7, in T-cell acute lymphoblastic leukemia (T-ALL) cells. Because tumor cells commonly evolve resistance to individual therapies, I have also investigated the potentially synergistic effects of combining two compounds that target transcriptional …
-
Structural principles governing kinase specificity towards RNA polymerase II C-terminal domain and their impact on transcription
… the pattern of phosphorylation conducted by CDK7 and to identify its capability of selectively preferring heptads. Utilizing the knowledge of the specificity of kinases, we use them to identify interactors by generating phosphorylated substrates in vitro and identifying differential …
-
An immunoproteomic approach to identifying cancer-associated autoantibody biomarkers
… in CRC patients versus HCs for citrullinated CDK7, MAGEB1, MAGEB5, MAGEB6 and SYCP1, whereas no significant (adjusted p-value > 0.05) difference in autoantibody signal was detected for these autoantigens on the noncitrullinated microarray for the same patient cohort. ROC analyses of these …
-
Regulation and function of interphase histone H1 phosphorylation in pluripotent cell differentiation
… after differentiation. Selective inhibition of CDK7 and CDK9, or siRNA depletion of CDK9 rapidly diminishes both the global levels and the enrichment of pS187-H1.4 at housekeeping genes. Moreover, inhibiting transcription with actinomycin D induces the accumulation of pS187-H1.4 at promoters and …
-
Transcriptome-wide association analysis of survival in colorectal cancer patients
… by stage showed promising results for gene CDK7 (stage 2 and 3 combined in transverse colon) and for gene SRSF12 (for stage 4 in whole blood). The results could not be replicated in COIN, however it should be highlighted that, beside lower sample sizes, the COIN dataset contains a special …