Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 29 for “"CDK5"”.
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Regulation of Phosphorylation of PPARγ by CDK5 in Obesity
… ratio of these drugs. Cyclin dependent kinase-5 (CDK5) which requires a non-cyclin partner (p35) for activity was proposed to phosphorylate Ser273, while obesity promoted cleavage of p35 to p25 thereby enhancing CDK5 phosphorylation of PPAR? (Choi et al 2010). However the sequence surrounding …
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Protein Phosphatase Inhibitor-1 and Cdk5: Of Molecules and Memory
… inhibitor-1 and cyclin-dependent kinase 5 (Cdk5) have been independently implicated in synaptic plasticity, learning, and memory. We began our studies with the identification, confirmation, and characterization of a novel Cdk5-dependent phosphorylation site (Ser6) on inhibitor-1. In the …
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Molecular modeling and SAR studies of CDK5/p25 selective inhibitors
… tangles. Cyclin dependent kinase 5 (CDK5) is a proline directed serine/threonine kinase, which expressed primarily in the central nervous system. In the biochemical process the CDK5-natural activator, p35 is cleaved by calpain to a shorter protein p25, which in turn …
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Design and Synthesis of Novel Benzimidazoles and Aminothiazoles as Small Molecule Inhibitors of CDK5/p25
… synthesis and biological evaluation of novel CDK5/p25 small molecule inhibitors. Cyclin dependent kinase 5 (CDK5) is a proline directed serine/threonine kinase which plays an important role in the pathology of Alzheimer's disease (AD). CDK5/p25 has been implicated in hyperphosphorylation of …
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The Role of Cdk5 in the Regulation of Dopamine Neurotransmission, Neuronal Excitability, and Reward-Related Behavior
Cyclin-dependent kinase 5 (Cdk5) regulates dopamine neurotransmission and synaptic plasticity and has been implicated as a homeostatic target of chronic psychostimulant exposure. In order to investigate the role of Cdk5 in the modulation of signal transduction pathways that regulate motivation and …
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Design and Synthesis of Benzimidazoles as CDK5 Inhibitors and Progress toward the Total Synthesis of Tubulysin D
… of 1,4,6-trisubstituted benzimidazoles as CDK5 inhibitors and the progress toward the total synthesis of tubulysin D.</p><p> Tubulysin is a natural product with potential anti-cancer activity. The two gamma-amino acids in the Tuv and Tup fragments of tubulysin were synthesized. Evans' …
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Regulation of synaptic function and plasticity by cyclin-dependent kinase 5
… kinase cyclin-dependent kinase 5 (Cdk5) is activated by its regulatory subunit, p35, to post-translationally modify substrates through phosphorylation. In this thesis, I provide several lines of evidence that Cdk5 plays a critical role in synaptic function and plasticity. First, we …
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Reassessing the role of Cyclin-dependent kinase 5 in tumourigenesis
The discovery of Cyclin-dependent 5 (Cdk5) added a new member to the mammalian Cdks, appearing uncharacteristic of its family members despite strong sequence homology. In contrast to the mitotic Cdks, Cdk5 exerts no apparent role in cell cycle regulation therefore its potential role in cancer is …
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Targeting protein kinases to manage or prevent Alzheimer’s disease
… kinase 1 (CDK1), cyclin-dependent kinase 5 (CDK5), glycogen synthase kinase-3 (GSK-3α and GSK-3β), and the protein kinase RNA-like endoplasmic reticulum kinase (PERK). AD intervention by reduction of amyloid beta (Aβ) levels is also possible through development of protein kinase C-epsilon …
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Regulation des mitochondrialen Zerfalls innerhalb der neuronalen Apoptose
… Apoptose. Durch Einsatz von Inhibitoren konnte CDK5 als eine Signalkinase identifiziert werden, welche die mitochondrialen Zerteilungsvorgänge während der neuronalen Apoptose reguliert. Als CDK5 Inhibitoren dienten dominant negative Mutanten, anti-CDK5 siRNS und Indolinon A. Durch Beeinflussung …
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Elektrophysiologische Untersuchung der synaptischen Übertragung und Kurzzeitplastizität an der neuromuskulären Synapse von Drosophila melanogaster
… (DG) sowie der Cyclin-abhängigen Kinase 5 (CDK5) untersucht. Für Larven, die GluRIIB exprimieren, jedoch nicht GluRIIA, konnte ein im Vergleich zu Wildtyp-Larven schnellerer Abfall (verminderter decay-τ) und verminderte Amplitude evozierter postsynaptischer Ströme (eEJCs) nachgewiesen …
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Interplay between collapsin response mediator protein 2 (CRMP2) phosphorylation and sumoylation modulates NaV1.7 trafficking
… of CRMP2 by cyclin dependent kinase 5 (Cdk5) was necessary for maintaining Nav1.7 surface expression and current density whereas phosphorylation by Fyn kinase reduced CRMP2 SUMOylation and Nav1.7 current density. Binding to Nav1.7 was decreased following (i) loss of CRMP2 SUMOylation, …
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Role of Talin1 Phosphorylation In Beta1 Integrin Activation and Prostate Cancer Metastasis
… Mechanistically, I demonstrated that increased Cdk5 kinase activity correlates with expression of its activator p35, and is responsible for talin1 phosphorylation and β1 integrin activation.</p> <p>Next, I demonstrated that talin1 phosphorylation is required for Prostate cancer bone metastasis …
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Regulation of CaMKKβ Dependent Signaling Pathways
… for these phosphorylations are identified as CDK5 and GSK3. These phosphorylation events are sequential with CDK5 priming for subsequent GSK3 phosphorylation. In addition to regulation of autonomous activity, phosphorylation of CaMKKβ regulates its half-life as determined in a radioactive …
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The Role of [beta]2-Syntrophin Phosphorylation in Secretory Granule Exocytosis
… conform a consensus for phosphorylation by Cdk5,which is known to modulate insulin secretion. The phosphorylation of GFP-b2-syntrophin and particularly the S75 allele by Cdk5 was exhibited with pharmacological inhibitors,by in vitro phosphorylation and by RNAi. Taken together, these findings …
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Roles of Myocardin-Related Transcription Factors in Muscle and Brain
… pathway in the regulation of the Pctaire-1/Cdk5 kinase cascade to govern actin dynamics. I conclude that MRTFs function as essential coregulators of SRF to control actin dynamics during neuronal development via the Cdk5/Pctaire-1 kinase cascade. I also explore the role of MRTF-A and -B in …
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Ruolo dei recettori 5-HT7 per la serotonina nell'attività mitocondriale e nella fisiopatologia della sindrome del cromosoma X fragile
… che il blocco della chinasi ciclina dipendente (Cdk5) aumentava mGluR-LTD in neuroni ippocampali WT ad un livello comparabile rispetto a quello osservato in neuroni Fmr1 KO e aboliva la reversione della mGluR-LTD mediata dal recettore 5-HT7 sia in neuroni WT che in Fmr1 KO, indicando che …
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The role of Polo-like kinase 2 in synaptic function and plasticity
… run-up during elevated activity also depended on CDK5, which acted as a "priming" kinase for the phospho-dependent binding of PIk2 to its substrate SPAR, a postsynaptic RapGAP.
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Investigating the regulation of the PCTAIRE-1 protein kinase : a new target of AMP-activated protein kinase and beyond?
… some insight into its upstream regulation by PKA/CDK5 phosphorylation. Proposed physiological functions include vesicle trafficking and neurite outgrowth, however, no consensus substrate motif has been identified to date, and there are no confirmed physiological substrates. We have identified …
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Identification And Functional Analyses Of Novel Protein Interactions And Post-Translational Modifications For The Transcription Factor Deformed Epidermal Autoregulatory Factor-1.
… activities. In vitro kinase assays identified CDK5 as potential kinase that can phosphorylate DEAF-1. These studies provide new insight into potential functions, properties, and regulation of DEAF-1.
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