Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"CDK phosphorylation"”.
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B-cyclin/CDK Regulation of Mitotic Spindle Assembly through Phosphorylation of Kinesin-5 Motors in the Budding Yeast, <italic>Saccharomyces cerevisiae</italic>
… it has been known for many years that B-cyclin/CDK complexes regulate the assembly of the mitotic spindle and entry into mitosis, the full complement of relevant CDK targets has not been identified. It has previously been shown in a variety of model systems that B-type cyclin/CDK complexes, …
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The Mitotic Exit Network detects spindle position and anaphase entry
… anaphase by inhibitory cyclin-dependent kinase (Cdk) phosphorylation of the MEN kinase cascade. During anaphase onset, Cdk activity decreases; creating a temporal signal that releases the MEN from inhibition. This temporal signal prevents MEN activation should the nucleus move into the daughter …
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Cell cycle control governing built-in asymmetry underlying the spindle pole body duplication cycle in Saccharomyces cerevisiae
… SPB duplication under cyclin-dependent kinase (CDK) control. In turn, I uncovered a mechanism for Spc72 spatial partition centred on two further SPB components that bind Spc72 in a cell-cycle dependent manner governed by CDK phosphorylation. The SPB components involved in my study as well as …
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Quantitative analysis of signaling networks in proneural glioblastoma
… associated with the GBM model, such as increased phosphorylation of ERK1/2, P13K, and PDGFRA, relative to murine brain. Phosphorylation of CDK₁ Y₁₅, which causes G₂ /M cell cycle arrest, was measured to be the most differentially phosphorylated site, with a 14-fold increase in the tumors. We used …
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Peak Mitotic Cyclin Permits Mitotic Exit
… are all regulated by Cyclin-dependent kinase (Cdk). Cyclin/Cdk complexes promote replication origin firing and mitotic entry, and conversely, inhibit pre-replication origin loading and exit from mitosis. Cyclin synthesis and degradation, Cdk phosphorylation and Cdk inhibitors are controlled …
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Regulation of Anaphase Promoting Complex Coactivators
… from mitotic exit through G1; inhibitory phosphorylation of Cdh1 by CDK and Polo kinase may allow accumulation of Cdh1 targets in the subsequent cell cycle. I demonstrate lethality of exact endogenous gene replacement of CDH1 with the CDK-unphosphorylatable CDH1-m11 allele; neither polo …
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Treslin and its role in the assembly of the replicative DNA helicase
… ring and DNA. S-phase Cyclin-Dependent Kinase (S-CDK) appeared to regulate Treslin’s interaction with Cdc45 and Mcm2–7, in which it targets a number of potential S-CDK phosphorylation sites present in Treslinext. As a part of this project, low-resolution Cdc45–Treslin and medium-resolution of MCM …
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Regulation of DNA replication by PP2A family phosphatases
… of cancer. S phase Cyclin-dependent kinase (S-CDK) plays a dual role in this regulation both by restricting helicase loading (licensing) to G1 phase, and by activating origin firing in S phase. The essential S-CDK phosphorylation of the limiting initiation proteins, Sld2 and Sld3, is sufficient …
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Anti-cancer Functions and Mechanisms of a pRb2/p130 Peptide Fragment
… to be able to inhibit the kinase activity of Cdk2. The region responsible for the inhibitory effect was further narrowed down to a 39-amino-acid sequence, which was named as Spa310. In this dissertation, the anti-cancer functions and mechanisms of Spa310 were studied. The synthesized Spa310 …
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Characterization of the specificity and functions of the protein phosphatase Cdc14
<p>Protein phosphorylation is perhaps the most ubiquitous posttranslational modification in eukaryotes and recent studies suggest that upwards of 75% of human proteins are phosphorylated. Many proteins are phosphorylated at multiple sites, often controlled by multiple kinases and phosphatases. …