Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"CDDO-Im"”.
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THE ROLE OF NRF2 IN PREVENTING OXIDATIVE/ELECTROPHILIC STRESS-INDUCED LIVER INJURY
… Oxidative stress and lipid accumulation play important roles in ethanol-induced liver injury. Ethanol increased serum ALT and LDH activities in Nrf2-null mice and wild-type mice, but not in Nrf2-enhanced mice, indicating that Nrf2-enhanced mice are resistant to ethanol toxicity. Ethanol …
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Dual regulation of transcription factor Nrf2 by Keap1 and the beta-TrCP/GSK-3 in cancer
… the mechanisms controlling Nrf2 activity is important in translational medicine.<br/><br/>Nrf2 is regulated by proteasomal degradation by Kelch-like ECH-associated protein 1 (Keap1) an E3 ubiquitin ligase substrate adaptor protein that recruits of cullin-3 (Cul3) to Nrf2 via its Neh2 domain. …
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The Effects of Acetylenic Tricyclic Bis-(Cyano Enone) on Cell Migration
Although cancer survival rates have significantly improved over the past few decades, the improvements are primarily due to early diagnosis and inhibiting cancer growth. Limited progress has been made in the treatment of cancer metastasis, which contributes to 90% of cancer related deaths, and …