Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"CDDO"”.
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Effect of CDDO-me on Myelopoiesis in Naive Mice and Mice Undergoing Bone Marrow Transplantation (BMT)
… toxicity effect of the synthetic triterpenoid CDDO-me in vivo, to investigate the effect of CDDO-me on myeloid expansion and mobilization, to determine the hematopoietic growth factor production in the serum of mice that received CDDO-me, and to look at the effect of CDDO-me on immune system …
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CDDO-ME induces apoptosis in breast cancer cells via Ca2+ influx-mediated dilation of endoplasmic reticulum and c-FLIP downregulation
… 11 L.Statistical analysis 12 III. RESULTS 13 1.CDDO-ME demonstrates a potent anti-cancer effect on breast cancer cells 13 2.CDDO-ME induces paraptosis-like cellular vacuolation prior to morphologies features of apoptosis in breast cancer cells 17 3.Ca2+ influx is crucial for CDDO-ME-induced …
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Protecting Healthy Cells Against the Negative Effects of Radiation Therapy for Lung Cancer
… cells. Synthetic triterpenoids, including CDDO-Me, act as anti-inflammatory, antioxidant modulators primarily by inducing the Nrf2/ARE pathway. In the documented series of experiments, I show that CDDO-Me can be used as a radioprotector in normal non-cancerous human lung and breast …
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Investigating the Effects of Particle Radiation Exposure on Lung Carcinogenesis
… anti-oxidative radioprotector (CDDO-EA) reduced 3B-1 induced oxidative stress and cancer initiation almost back to baseline. Thus, exposure to 3B-1 elicits significant changes in lung cancer initiation that can be mitigated using CDDO-EA.
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Airway Inflammatory States in Response to Environmental Pollutants and the Influence of Oxidative Balance
… o-3,12-dioxooleana-1,9(11)-dien-28-oyl]imidazole (CDDO) a triterpenoid mimetic of the Nrf2 anti-oxidant DNA binding element. Data obtained confirmed the hypothesis that both acrolein and sulfite induced ROS in mast cells and enhanced degranulation of inflammatory mediators in vitro. Treatment of …
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THE ROLE OF NRF2 IN PREVENTING OXIDATIVE/ELECTROPHILIC STRESS-INDUCED LIVER INJURY
… 2-cyano-3,12-dioxooleana-1,9-dien-28-imidazolide (CDDO-Im), the most effective and potent Nrf2 activator known. However, none of the tested compounds were more potent in activating Nrf2 than CDDO-Im. In addition, chemical structural relationship analysis of these 238 compounds showed enrichment of …
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Dual regulation of transcription factor Nrf2 by Keap1 and the beta-TrCP/GSK-3 in cancer
… -3,12-dioxooleana-1,9(11)-diene-28-oyl]imidazole (CDDO-Im), diethyl maleate (DEM), curcumin, carnosol, ferulic acid and sulforaphane (SFN) to activate Nrf2-target genes in a Keap1-dependent or Keap1-independent manner was tested. It was discovered that all compounds, except for SFN, activate …
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Reactions for rapid access to C3a oxygenated pyrroloindolines and its application towards a novel route to pestalazine A
… a class of synthetic triterpenoids (CDDO) was identified that efficiently inhibit ghrelin acylation. To verify which functional group was responsible for hGOAT activity, some minimally functionalized steroid derivatives were synthesized in this project. These compounds act as covalent …
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The Effects of Acetylenic Tricyclic Bis-(Cyano Enone) on Cell Migration
Although cancer survival rates have significantly improved over the past few decades, the improvements are primarily due to early diagnosis and inhibiting cancer growth. Limited progress has been made in the treatment of cancer metastasis, which contributes to 90% of cancer related deaths, and …