Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 75 for “"CD86"”.
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Gestörte Expression von CD70 und CD86 auf naiven CD27-B-Lymphozyten von Patienten mit Variablem Immundefektsyndrom (CVID)
… werden, die eine signifikant erniedrigte CD86 und CD137 Expression nach in vitro Stimulation von PBMC oder gereinigten B- Zellen mit anti- IgM und IL-2 aufweist. In der vorliegenden Arbeit erweiterten wir unsere Untersuchungen, indem wir mittels eines Zellsorters gereinigte naive B- Zellen …
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Gestörte Expression von CD86 und ein verändertes intrazytoplasmatisches Zytokinmuster in Lymphozyten von Patienten mit Variablem Immundefektsyndrom (CVID)
… verminderte Expression des CD28/CTLA-4 Liganden CD86 (B7-2) und des Aktivierungsmarker CD137 aufweisen. Korrelierend fanden sich erniedrigte Werte für die mRNA von CD86. Eine kombinierte Stimulation über den B-Zell-Antigenrezeptor und Kreuzvernetzung von CD40 konnte die Defekte in der CD86 und …
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Regulation of Dendritic cell function by the ocular microenvironment
… inhibited DC maturation, with reduced MHC and CD86 expression, and reduced capacity to induce proliferation of allogeneic T cells, an effect which was cortisol and TGFβ2 dependent. In contrast, exposure to uveitis AqH generated a distinct DC profile with IFNγ dependent elevation of MHC class I, …
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Molecular Mechanisms of Promyelocyte Maturation: Implications for Immune Dysfunction in Type II Diabetes
… expression of the co-stimulatory marker B7.2 (CD86) and three, the expression of CD86 and the production of cytokines in phorbol-12-myristate-13-acetate (PMA)-stimulated promyelocytes is regulated by calcium calmodulin kinase kinase alpha. These data together indicate that promyelocyte …
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Astrocytes modulate microglial phenotype and dendritic cell-like properties
… well as co-stimulatory molecules CD40, CD80 and CD86 necessary for antigen presentation to and activation of T cells. Co-stimulatory molecule expression can be induced in isolated microglia in vitro by sequential treatment with granulocyte monocyte colony-stimulating factor (GM-CSF) followed by …
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Respiratory infection with the paramyxovirus SV5 results in maturation and cytokine secretion in CD103- and CD103+ dendritic cell subsets.
… 2. costimulatory molecules (eg. CD80, CD86), and 3. secreted cytokines (e.g. IL-12, type I IFN). The first two signals require direct DC and T cell contact. In contrast, the third signal could be obtained from the local environment. In this study, the DC in the MLN are divided into four …
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A novel method of generating Dendritic cells in vitro using the KG-1 cell line and its use as a model for testing effects of lactic acid bacteria
… expression. Expression of CD83, CD11c, CD123, CD86, HLA-DR and DC-SIGN was assessed by immunofluorescence and flow cytometry. KG-1 cells stimulated with 10 ng/ml PMA and 100 ng/ml Ionomycin were found to be the ideal model for obtaining Dendritic Like Cells (DLCs) in vitro. The effect of lactic …
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Expression Profiles of Molecules Involved in Antigen Presentation in Gangliosides-stimulated Primary Astrocytes from Rat brain
… costimulation are CD40, ICAM-1, CD80 (B7-1) and CD86 (B7-2). In astrocytes, mRNA expressions of the above molecules were constitutive and that of CD86 was further induced by treatment of Gmix. Those expression patterns are the same in IFN-gamma-treated cells. Next, I tested the surface expression …
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Altered Expression of Costimulatory Molecules in Behcet's Disease According to Clinical Activity
… cytotoxic T-lymphocyte antigen-4 (CTLA-4)/CD80, CD86 and programmed death-1 (PD-1)/programmed death-ligand 1 (PD-L1) receptor/ligand systems are important. Also, regulatory T (Treg) cells play an important role in maintaining immune homeostasis. PURPOSE: The objective of the present study was to …
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Effect of Medicinal Herbal, Panax Notoginseng, on the Fate and Function of Professional Antigen Presenting Cells
… of accessory molecules MHC II, CD40 and CD86, were decreased dependent on notoginseng exposure time-points relative to LPS stimulation. LPS induced IL-1â, IL-6 and IL-12 production was also decreased with concurrent notoginseng treatment for 24 hours. Notoginseng decreased TNF-á and CD40 …
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Effect of Medicinal Herbal, Panax Notoginseng, on the Fate and Function of Professional Antigen Presenting Cells
… of accessory molecules MHC II, CD40 and CD86, were decreased dependent on notoginseng exposure time-points relative to LPS stimulation. LPS induced IL-1â, IL-6 and IL-12 production was also decreased with concurrent notoginseng treatment for 24 hours. Notoginseng decreased TNF-á and CD40 …
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Multiple sclerosis associated SNPs influencing B cell expression of co-stimulatory receptors and T cell responses
… respectively influence the expression of CD86 and CD40 in freshly collected (ex-vivo) B cells. In my research, I sought to extend this work by investigating the impact of these variants in the context of activation in an effort to refine understanding of the molecular mechanisms underlying …
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Targeting Innate Immune Memory to Alleviate Monocyte Exhaustion and Chronic Inflammation
… monocytes and restoring the expression of CD86. Functionally, M-MA treatment rejuvenates the mitochondrial function of exhausted monocytes and alleviates their suppressive effect on T cells. Mechanistically, M-MA ameliorates cellular stress signaling by inhibiting Src-STAT1 mediated …
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Consequences of Aryl hydrocarbon receptor activation in dendritic cells
… Additionally, TCDD increased the expression of CD86 and CD54, while decreasing the frequency of CD11a and MHC II on the splenic CD11c<sup>high</sup> DCs. Although TCDD did not alter the number and frequency of CD11c<sup>low</sup> splenic DCs, it decreased their MHC II and CD11a expression. The …
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Consequences of Aryl hydrocarbon receptor activation in dendritic cells
… Additionally, TCDD increased the expression of CD86 and CD54, while decreasing the frequency of CD11a and MHC II on the splenic CD11c<sup>high</sup> DCs. Although TCDD did not alter the number and frequency of CD11c<sup>low</sup> splenic DCs, it decreased their MHC II and CD11a expression. The …
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Immune modulation mechanisms of porcine circovirus type 2
… of programmed death ligand-1 (PD-L1), IL-10, CD86, swine leukocyte antigen-1 (SLA-1), and swine leukocyte antigen-2 (SLA-2). Expression levels of PD-L1 were significantly increased in PCV2 and PRRSV co-infected MoDCs. SLA-1, SLA-2, and CD86 expression levels were significantly decreased in the …
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TREM-2 and Dendritic Cells in the Pathogenesis of Allergic Airway Inflammation
… as high expression of costimulatory molecule CD86 and chemokine receptor CCR-7.|Whole lungs from OVA-sensitized and challenged mice were then examined for TREM-2 expression. As seen with other inflammatory conditions, TREM-2 was found to be upregulated in the airways of mice exposed to OVA …
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Modulation of dendritic cells by human neutrophil elastase and its inhibitors in pulmonary inflammation
… DC co-stimulatory molecules (CSM; CD40, CD80 and CD86), which was due to its proteolytic activity. NE-treated LPS-matured DCs were less efficient at presenting ovalbumin (OVA) peptide to naïve OVAspecific transgenic (D011.10) T cells. In addition, immature DCs (iDC) simultaneously treated with LPS …
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Role of Macrophage Subsets in CD8+ T Cell Dysfunction in Chronic HCV Infection
… from advanced fibrosis patients show increased CD86 expression, reduced spontaneous TNF-α and increased spontaneous IL-10 production. In uninfected controls, co-culturing CD8+T cells with M1 macrophages significantly increased the percentage of CD107a+ and IFN-γ+ CD8+T cells in a …
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Innate Immune Responses in the Alternaria-Dendritic Cell Interaction
… of MHC II and other co-stimulators, like CD40, CD86, and OX40L, were highly up regulated. In order to determine how different cell wall components affect the T cells, we conducted co-culture experiments of BMDCs and lymphocytes in this study. Both spores and Alt a1 did not induce IL-4 in mixed …
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