Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"CD8-Positive T-Lymphocytes"”.
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Investigation of Divergent Metabolic Programs in the Tumor-Immune Microenvironment
… glycolytic activity and effector functions of CD8+ T-cells, contrary to the current understanding that lactate dampens immune cell functions. The comparison study between lactate and lactic acid further demonstrated that CD8+ T-cells undergo cell death that is dependent on pH levels, with …
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STING Signaling in Adaptive Immunity and Respiratory Physiology
The author publishes under the names Kennady Knox and Kennady Abbott.
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The Role of Therapy-Induced CD8+ T Cells in a Mouse Model of Multiple Sclerosis
… induces an upregulation of cytotoxic, suppressor CD8+ T cell responses, suggesting that these cells are integrally involved in mediating the immune effects of this drug. In this study, we show that GA induces robust CD8+ T cell responses even in mice. Whereas GA immunization ameliorates the …
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Development of an IL12 Prodrug to Treat Solid Tumors with Minimal Toxicity
… predominantly through pre-existing, intratumor CD8+ T cells that produce IFNγ after direct binding of the prodrug to cell surface IL12 receptor complexes. Pro-IL12 also worked in combination with TKI and ICB to achieve even more potent tumor control. In a follow up study, I propose that a higher …
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CNS-Specific, Autoreactive CD8+ T Cells Have a Regulatory Role in Autoimmune Demyelination
… several reports have implicated both CD4+ and CD8+ T cells in the pathogenesis and regulation of these diseases. In this study, we show the presence of antigen-specific, autoreactive CD8+ T cells in several models of EAE. Furthermore, through series of adoptive transfer studies, we show that …
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Autoregulatory CD8 T-Cells Modulate CNS Autoimmune Disease by Targeting Encephalitogenic CD4 T-Cells
… of this disease. While it is known that CD8 T-cells are present, oligoclonally expanded and are the predominant T-cell population in the MS CNS lesion, their antigen specificity and function remains to be elucidated. Using a murine model of MS, experimental autoimmune encephalomyelitis …
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Regulation of Human Cytotoxic T Lymphocyte Functions by IL-12
CD8+ T cells or cytotoxic T lymphocytes (CTLs) play a major role in our defense against intracellular pathogens by secreting effector cytokines and directly killing infected cells. Upon sensing of pathogen, antigen presenting cells secrete innate cytokines such as IL-12 and IFN-α. CTL functions are …
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Dendritic Cells Suppress Pathogen-Induced Inflammasome Activation to Prime Naïve T Cells
… the ability of cDCs to prime both CD4 and CD8 T cells. Transcription factors IRF8 and IRF4, in cDC1s and cDC2s respectively, mediate this suppression of inflammasome activation by limiting the expression of inflammasome-associated genes. Additionally, overexpression of either of IRF4 or …
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Reciprocal Regulation of CD4+ and CD8+ T Lymphocyte Effector and Memory Fates by Interleukin 12 and Type 1 Interferon
… effector and memory responses in human CD4+ and CD8+ T cells. My work has found that IL-12 drives the development of effector CD4+ and CD8+ T cells. In contrast, IFN-a/b was incapable of promoting these responses and this was due to a difference in the kinetics of activation of two downstream …
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CD8+ T Cells Are Required for the Therapeutic Action of Glatiramer Acetate in Autoimmune Demyelinating Disease
… has previously shown that GA therapy induces CD8+ T cell responses responsible for suppression of CD4+ T cell responses in MS patients. Using a murine model of MS, experimental autoimmune encephalomyelitis (EAE), we also demonstrated that CD8+ T cells are necessary in mediating the therapeutic …
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Dysregulated B Cells in Relapsing Remitting Multiple Sclerosis and Their Impact on T-Cell Function
Relapsing-remitting multiple sclerosis (MS) is an autoimmune mediated inflammatory demyelinating disorder of the central nervous system. The role of B cells in the pathoetiology of MS is substantiated by cell depletion therapies but is not well understood. We hypothesized that B cells from MS …
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Modulation of CD8+ T Cell Function by Beta2-Adrenergic Receptor Signaling
… work has demonstrated that various subsets of CD8+ T cells have differential expression of the ADRB2 transcript. The role of ADRB2 signaling on the differentiation and acute effector functions of CD8+ T cells remains poorly understood. More importantly, its effect on CD8+ T cell memory …
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AXL Targeting Restores PD-1 Blockade Sensitivity of STK11/LKB1 Mutant NSCLC Through Expansion of TCF1+ CD8 T Cells
… because KPL mutant NSCLCs lacked TCF1-expressing CD8 T cells, a phenotype that was recapitulated in human STK11/LKB1 mutant NSCLCs. We found that systemic inhibition of Axl results in increased type I interferon secretion from dendritic cells that expands tumor-associated TCF1+ PD-1+ CD8 T cells, …
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Sympathetic Neural Control of Inflammation by ADRB2-Mediated IL-10 Secretion
The nervous and immune systems reciprocally regulate their functions through the release of chemical messengers. Norepinephrine (NE), a neurotransmitter released by catecholaminergic nerve endings, allows the sympathetic nervous system to communicate with immune cells through adrenergic receptors …