Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 213 for “"CD8 T cell"”.
-
Mitochondrial regulation of CD8+ T cell cytotoxicity
… importance of mitochondria in the context of T cell development, differentiation, signalling and exhaustion. However, the question of whether mitochondria can actively participate to the killing activity of differentiated, cytotoxic CD8+ T cells (CTLs) remains unanswered. In this work I analyse …
-
Hedgehog signalling in CD8+ T cell memory
[Restricted]
-
CD8⁺ T Cell Response to Influenza Virus
… effectively dispatched by the immune system. The cell-mediated lysis of infected cells is a particularly important step in clearing the infection. Antigen specific CD8+ T lymphocytes are selected and activated in the mediastinal lymph node, proliferate and gain effector function, then migrate to …
-
Cytokine signaling control of naïve CD8⁺ T-cell homeostasis
… immune responses requires a large naive T-cell population with a wide diversity of target specificity. Naive CD8⁺ T-cells depend on T-Cell Receptor (TCR) and ye cytokine signals for their homeostatic survival and proliferation, but differences in sensitivity to these homeostatic signals …
-
Supramolecular Peptide Nanofiber Vaccines for Eliciting CD8+ T-cell Responses
CD8+ T cells play a central role in immunity against intracellular pathogens and cancer.Vaccines that elicit robust CD8+ T cell responses are desirable for protection against such infectious diseases and cancers. Subunit vaccines using whole protein or peptide epitopes are becoming increasingly …
-
Characterization of CD8 T cell responses in Mycobacterium Tuberculosis infection
… and magnitude of CFP10 and ESAT6-specific CD8 T cell responses in individuals with latent Mycobacterium tuberculosis (MTB) infection (LTBI) and active TB disease, and further define MTB-specific CD8 T cell phenotypes associated with latent infection and active disease. Ex vivo IFN? Elispots …
-
Streptococcus pneumoniae mediated negative regulation of CD8+ T cell effector function
… pathogen can modulate the ongoing adaptive CD8+ T cell response to IAV.
-
Modulation of CD8+ T Cell Function by Beta2-Adrenergic Receptor Signaling
… upon stimulation, which can modulate immune cell function primarily through the beta2-adrenergic receptor (ADRB2). Our previous work has demonstrated that various subsets of CD8+ T cells have differential expression of the ADRB2 transcript. The role of ADRB2 signaling on the differentiation …
-
Constraints on the CD8 T cell response in chronic HBV infection
… by a large influx of non-virus specific CD8 T cells, which we hypothesize could provide insights into mechanisms of failure of viral control and liver damage in this setting. We compared the effector function of total circulating and intrahepatic CD8 T cells in CHB patients and healthy …
-
Continuous expression of TOX safeguards exhausted CD8 T cell epigenetic fate
CD8 T cell exhaustion is a major barrier limiting anti-tumor therapy. Though checkpoint blockade temporarily improves exhausted CD8 T cell (Tex) function, the underlying epigenetic landscape of Tex remains largely unchanged, preventing their durable “reinvigoration.” Whereas the transcription …
-
Immunization with synthetic nanoparticles to generate mucosal CD8 T Cell responses
… vaccine to stimulate mucosal and systemic CD8 immunity. We first assessed the ability of ICMVs to elicit mucosal CD8 response, against the model antigen ovalbumin (OVA), by administration of the nanoparticles through the lungs. We explored the use of 2 different Toll-like receptor agonists …
-
The Role of TCR Engagement Strength in Antitumor CD8 T Cell Exhaustion
… part by the persistence of progenitor exhausted CD8 T cells (Tpex). Tpex serve as a source for the pool of effector T cells that tend to have a short lifespan or eventually become dysfunctional in uncleared tumors. In contrast to the short-lived feature of their daughter cells, Tpex are able to …
-
Regulators of CD8+ T-cell mediated vaccine immunity against pulmonary fungal infections
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2024-08-01
-
Antioxidant PRDX1 limits CD8+ T cell effector function in the tumour microenvironment
CD8+ T cells have been recognised for their critical role in detecting and orchestrating effective anti-tumour immunity. However, under this selection pressure, cancer cells progressively evolve mechanisms to undermine and subvert host immunity. Immunotherapy aimed at restoring or enhancing …
-
Regulation of Anti-Viral Cd8+ T Cell Responses by the Pd-1 Pathway
… critical immunoregulatory pathway for modulating CD8+ T cell responses. This pathway has become an important therapeutic target in cancer and chronic viral infections, where blockade of PD-1/PD-L1 reverses CD8+ T cell exhaustion and improves outcomes. However, it remains unclear how PD-1 pathway …
-
Role of Macrophage Subsets in CD8+ T Cell Dysfunction in Chronic HCV Infection
Chronic HCV infection causes generalized CD8+T cell impairment, not limited to HCV-specific CD8+ T cells. Infiltrating monocyte-derived macrophages contribute to a micro- environment that could impact CD8+T cells trafficking through the liver. Macrophages can differentiate into pro-inflammatory …
-
Mechanisms of CD8+ T Cell Mediated Virus Inhibition in HIV-1 Virus Controllers
<p>CD8+ T cells are associated with long term control of virus replication to low or undetectable levels in a population of HIV+ therapy-naïve individuals known as virus controllers (VCs; <5000 RNA copies/ml and CD4+ lymphocyte counts >400 cells/µl). These subjects' ability to control viremia in …
-
Influence of the potency of antigen presentation on CD8+ T cell differentiation and memory
CD8+ T cells curtail the proliferation of intracellular pathogens. However, the influence of the potency of stimulation on the development of CD8+ T cell memory is not clear. Using recombinant Ovalbumin (OVA) expressing intracellular bacteria, Mycobacterium bovis (BCG) which induces muted T cell …
-
T cell receptor- and calcium-induced Gli signalling in CD8+ T cell effector function
CD8+ cytotoxic T lymphocytes (CTLs) are potent effector cells of the immune system, capable of directly lysing neoplastic and infected cells. The Hedgehog (Hh) signalling pathway - a critical regulator of embryonic development and adult tissue maintenance - is induced in CTLs following TCR …
Page 1 of 11