Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 338 for “"CD8+ T cells"”.
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The regulation of CD8+ T cells by nutrient availability
… was to explore how nutrient availability control CD8+ T lymphocytes. The focus was the regulation and function of autophagy as CD8 T cells encounter amino acid deprived conditions. The study also examined the role of the AMP dependent kinase in CD8+ T cell responses to metabolic stress. To study …
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A Microfluidics-Based Approach For Isolation of Antigen-Specific Cd8+ T Cells
… <p> Immunotherapies that leverage tumor-specific CD8<sup>+ </sup>cytotoxic T cells have shown great promise for the treatment of NSCLC. However, although highly promising, the success of these therapies has largely been hampered by the challenge of isolating tumor-specific CD8<sup>+</sup> T cells …
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CNS-Specific, Autoreactive CD8+ T Cells Have a Regulatory Role in Autoimmune Demyelination
… by adoptive transfer of CNS-specific activated T cells. The vast majority of studies in MS and EAE have focused on the role of CD4+ T cells in this disease, with the underlying assumption that MS, like EAE, is a CD4+ Th1-mediated autoimmune disease. However, several reports have implicated both …
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Intrinsic heterogeneity in the survival and proliferation capacities of naïve CD8⁺ T cells
… within the seemingly homogeneous naive CD8⁺ T cell population in their survival and proliferation capacities. This heterogeneity is predictably marked by the surface level of CD5. NaYve CD8⁺ T cells that are also CD5hi have a greater intrinsic capacity to proliferate both in response to …
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Autoregulatory CD8 T-Cells Modulate CNS Autoimmune Disease by Targeting Encephalitogenic CD4 T-Cells
… is believed that myelin sheath-targeting CD4 T-cells are important mediators of this disease. While it is known that CD8 T-cells are present, oligoclonally expanded and are the predominant T-cell population in the MS CNS lesion, their antigen specificity and function remains to be elucidated. …
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LINOLEIC ACID UNLEASHES THE ANTI-TUMOR POTENTIAL OF CD8 T CELLS BY PROMOTING METABOLIC REPROGRAMMING
… and function of adoptively transferred T cells limit its efficacy, especially in solid tumors. Metabolic constraints imposed by the tumor microenvironment (TME) greatly influence the success of immune-based therapies. A common metabolic alteration in the TME is lipid accumulation, a …
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The Role of Therapy-Induced CD8+ T Cells in a Mouse Model of Multiple Sclerosis
… is the induction of a Th1 to Th2 shift in CD4+ T cells. We have shown that, in human MS, GA therapy induces an upregulation of cytotoxic, suppressor CD8+ T cell responses, suggesting that these cells are integrally involved in mediating the immune effects of this drug. In this study, we show that …
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CD8+ T Cells Are Required for the Therapeutic Action of Glatiramer Acetate in Autoimmune Demyelinating Disease
… has previously shown that GA therapy induces CD8+ T cell responses responsible for suppression of CD4+ T cell responses in MS patients. Using a murine model of MS, experimental autoimmune encephalomyelitis (EAE), we also demonstrated that CD8+ T cells are necessary in mediating the therapeutic …
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Investigating the interdependence of human BH3-only protein Noxa and glutamine in activated CD8+ T cells.
… not expressed in unstimulated or naïve human T cells but is induced in CD8+ T cells upon receptor engagement. Activated T cells prepare for rapid proliferation by switching from metabolizing glucose for energy production via OxPhos to diverting the sugar for biomass generation through aerobic …
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THE INNATE CYTOKINE IL-18 INHIBITS CNS AUTOIMMUNITY THROUGH PREFERENTIAL ACTIVATION OF PROTECTIVE CD8 T-CELLS
… by IL-18 responsive, myelin-autoreactive CD4T-cells (CD4Tauto). Prior data suggested that IL-18 would exacerbate immunopathology in EAE. Instead, excess IL-18 was profoundly protective. Excess IL-18 did not impair CD4Tauto priming or early expansion. Rather, it selectively restricted later …
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The RNA-Binding protein PTBP1 plays a role in the activation of mouse CD8 T cells
CD8 T cells play a pivotal role in immune responses against intracellular pathogens, including viruses and bacteria, and in tumour surveillance. After encountering an antigen, CD8 T cells undergo cell growth, clonal expansion, and acquisition of effector functions. These steps are a result of …
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Characterisation of high and low avidity peptide specific CD8+ T cells using immunologic, transcriptomic and proteomic tools
… is the generation of high avidity cytotoxic T cells which can recognise and respond to very low concentration of antigens. This sensitivity of T cells is usually determined by peptide titration ELISpot assays. Even though these assays are generally useful, they are laborious and sample …
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Identification and analysis of Il-2 induced Stat5 Target genes in Human CD4 and CD8 T cells
… in fresh and activated primary human CD4 and CD8<br/>peripheral T cells.<br/>Six libraries were generated, which identified 329 STAT5a and/or STAT5b-specific<br/>binding sites of which 87% contained canonical GAS motifs, TTCN3GAA and/or<br/>TTN5AA. Genomic mapping of sites revealed the …
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The role of nonclassical MHC class I products in the development and function of CD8+ T cells
… I products present pathogen-derived peptides to CD8+ cytotoxic T cells. This interaction mediates the detection and clearance of intracellular infections. Emphasis has been placed on the critical role of classical class I MHC products in the development and function of CD8+ T cells. In this …
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AXL Targeting Restores PD-1 Blockade Sensitivity of STK11/LKB1 Mutant NSCLC Through Expansion of TCF1+ CD8 T Cells
… because KPL mutant NSCLCs lacked TCF1-expressing CD8 T cells, a phenotype that was recapitulated in human STK11/LKB1 mutant NSCLCs. We found that systemic inhibition of Axl results in increased type I interferon secretion from dendritic cells that expands tumor-associated TCF1+ PD-1+ CD8 T cells, …
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