Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 23 for “"CD8+ T Lymphocytes"”.
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Transcriptional analysis of the role of CD8+ T lymphocytes in acute neural herpes simplex virus infection / David C. Tscharke.
… to analyse the molecular events associated with CD8+ T lymphocyte activity in HSV infected sensory ganglia. The role of CD8+ T cells in cytokine responses to ganglionic HSV infection is investigated, with particular reference to the Th1/Th2 paradigm and a known anti-viral mediator, IFN-[gamma]. A …
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Adaptive immune responses in atherosclerosis - or how to prolong the use of your yellow socks
… risk of rupture. I also elucidate the role of CD8+ T lymphocytes in the development of atherosclerotic lesions and test the association between CD8+ T lymphocytes in blood and cardiovascular disease.
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CD8⁺ T Cell Response to Influenza Virus
… step in clearing the infection. Antigen specific CD8+ T lymphocytes are selected and activated in the mediastinal lymph node, proliferate and gain effector function, then migrate to the lungs, where they selectively destroy infected cells. The CD8+ effector population pool undergoes a phase of …
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Characterizing the Impact of Specific Genetic Mutations on Chemotherapy Resistance and the Efficacy of Oncolytic Viruses for the Treatment of Ovarian Cancer
… was associated with activation of CD4+ and CD8+ T lymphocytes in the peritoneal TME. In summary, VSV∆M51-based immunotherapy has shown promise in diverse murine models of EOC bearing clinically relevant mutations.
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Das T-Zell-Rezeptor-Repertoire bei der Polymyositis
… (PM) is an autoimmune disease cased by CD8+ T lymphocytes that destroy HLA class I-expressing skeletal muscle fibres. Recently we demonstrated that the autoaggressive T lymphocytes in PM muscle are clonally expanded. We employed a new PCR-based method to identify and characterize …
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CD8+ lymphocyte and progenitor cell mobilization during acute psychological stress and betaadrenergic stimulation
… (\(\beta\)AR) stimulation on the mobilization of CD8+ T lymphocytes (CD8TLs) and progenitor cell (PC) populations. Chapter 2 demonstrated that CD8TL stress- and \(\beta\)AR- sensitivity increases in parallel with greater effector functions and cell differentiation. As Cytomegalovirus (CMV) …
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Immune memory and activation markers in systemic lupus erythematosus
… found that transcriptional profiling of purified CD8+ T lymphocytes identifies two distinct prognostic subgroups in SLE, termed v8.1 and v8.2. It was found that more subjects in group v8.1 have shorter time to first flare, increased flare rate, and had increased expression of IL7R and Bcl2. These …
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Characterising the effects of 1,4,5-Oxathiazinane-4,4-dioxide (OTD) on non-neoplastic cells and primary and metastatic melanoma cells in vitro
… melanoma cells) and the adaptive immune system (CD8+ T lymphocytes). The physiological and pathological functions of these cell types were assessed in vitro with five concentrations of OTD (0.25mM, 0.5mM, 0.75mM, 1mM and 1.25mM). Given the critical role of wound healing in the post-operative …
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Synthesis of Novel Glycolipid Agonists of the Protein CD1d
Invariant NKT (iNKT) cells are a subset of T lymphocytes that express an invariant \(\alpha\) \(\beta\) T cell receptor (TCR) as well as an NK1.1 marker. They play an important role in autoimmune diseases, such as type I diabetes and lupus. In contrast to conventional CD4+ and CD8+ T lymphocytes …
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Reciprocal Regulation of CD4+ and CD8+ T Lymphocyte Effector and Memory Fates by Interleukin 12 and Type 1 Interferon
… effector and memory responses in human CD4+ and CD8+ T cells. My work has found that IL-12 drives the development of effector CD4+ and CD8+ T cells. In contrast, IFN-a/b was incapable of promoting these responses and this was due to a difference in the kinetics of activation of two downstream …
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cholera Toxin B Subunit-Diabetes Autoantigen Fusion Proteins Modulate Dendritic Cell Function and T Cell Morphogenesis
… populations involved in suppression of CD4+ and CD8+ T lymphocytes responsible for the initiation of diabetes autoimmunity. Further, vaccine inoculated DCs suppressed T cell pro-inflammatory cytokines IFN-γ, IL-17 and IL-2 guiding T cell morphogenesis in the direction of tolerance rather than …
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Zinco, invecchiamento e sistema immunitario: effetti sull'apoptosi e sulla proliferazione dei linfociti
… stress, differentiation, was evaluated in total lymphocytes, in CD4+ and in CD8+ T lymphocytes from young and old healthy subjects in presence of different concentration of zinc in vitro. Literature data reported that during ageing the levels of these proteins increase and concomitantly they lose …
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Route of Nutrient Administration Alters Intestinal Immune Cell Composition in Neonatal Piglets
… and a greater number of intestinal CD4+ and CD8+ T-lymphocytes, goblet cells, and mast cells. An inverse correlation between T-lymphocyte numbers and intestinal morphology was observed (r > --0.80; P < 0.05), suggesting an association between TPN-induced gut atrophy and intestinal …
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T-lymphocyte senescence and hepatitis C virus infection
… efficacy of adaptive immune system function. T-lymphocytes from aged subjects demonstrate multiple phenotypic and functional changes, including telomere shortening. Short telomeres are associated with poor proliferative capacity, pro-inflammatory responses and increased mortality in clinical …
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Functional relationships among lck kinase and the lat and grb2 adaptors in the intracellular signaling cascade of the tcr/cd3 complex: implications in thymic development and lymphocyte activation
… of cellular tolerance and homeostasis. T lymphocytes need to undergo processes of development, differentiation and activation in order to perform their functions, and for this purpose, they express the TCR receptor in their membrane, which upon activation triggers a very complex …
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Microfluidic sensor for white blood cell counting and flow metering
… the device for counting of CD4+ and CD8+ T lymphocytes, which are the primary diagnostics biomarkers for HIV/AIDS.
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RNA binding proteins ZFP36 and ZFP36L1 limit CD8+ T cell differentiation and effector function
… during thymopoiesis and in developing B lymphocytes, where they limit DNA damage response and cell cycle progression. Furthermore, ZFP36L2 has been shown to repress translation of preformed Ifng mRNA and maintain quiescence in CD8+ memory T-cells. However, roles for the ZFP36 proteins in …
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The role of extracellular signal-regulated kinases (ERKs) in T lymphocytes
… of the MAP kinases ERK1/2 in naïve and effector CD8 T lymphocytes. Initial experiments showed that inhibition of ERK1/2 activation impaired protein synthesis and reduced cell growth and proliferation of T cell antigen receptor (TCR) stimulated naïve CD8 T cells. On the basis of this data, …
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Investigating the interdependence of human BH3-only protein Noxa and glutamine in activated CD8+ T cells.
… or naïve human T cells but is induced in CD8+ T cells upon receptor engagement. Activated T cells prepare for rapid proliferation by switching from metabolizing glucose for energy production via OxPhos to diverting the sugar for biomass generation through aerobic glycolysis, utilizing …
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