Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 8 of 8 for “"CD74"”.
-
Discovery of Immunogenic Neo-peptides from Actionable RNA Fusion CD74-NRG1 for Developing Cancer Vaccines
This study investigates the CD74-NRG1 fusion protein as a tumor-specific neoantigen source and presents a comprehensive pipeline for identifying and validating immunogenic neoantigens from chimeric RNAs, with promising implications for personalized cancer vaccines. The CD74-NRG1 fusion, resulting …
-
Regulation of CD74 expression in response to Human Interferon Gamma and Lipopolysaccharide on Human Trophoblast Derived Cells: Relevance for Human Feto-Maternal Tolerance.
… fetal-maternal tolerance. One such receptor is CD74; a membrane-bound protein involved in HLA class II- mediated antigen presentation and a macrophage migration inhibitory factor (MIF) receptor. CD44 is the signalling component of the MIF-CD74 receptor complex. The expression of CD74, MIF and …
-
The Role of Immunological Receptors CD74 and CD44 in Association with the Macrophage Migration Inhibitory Factor (MIF) on Human Breast Cancer Derived Cells
… whose ligand is the transmembrane receptor CD74. Recent data suggests that CD74 is involved in proinflammatory responses and tumorigenesis but detailed mechanisms are not fully understood. In normal cells CD74 functions as a chaperone of human leukocyte antigen (HLA)-DR biosynthesis and is …
-
Dissecting the impact of macrophage migration inhibitory factor (MIF) on host immune response
… triggered by such interactions. In addition to CD74, a previously identified receptor, CXCR4 also interacts with ChMIF. Moreover, the formation of receptor complexes was shown between CXCR4 and CD74. MIF signaling through CXCR4 and CD74 led to cell chemotaxis and proliferation activity as well …
-
Involvement of Scribble protein in breast cancer invasion and metastasis
… cancer invasion and metastasis. This was due to CD74 overexpression in lymph node metastatic triple negative breast cancers. Investigating how changes in serine phosphorylation status at these sites affect the regulation of invasion and metastasis in breast cancer was the focus of this study. …
-
Development of a Neoepitope Prioritization Platform to Identify Immunogenic Neoantigens from Oncogenic FGFR3-TACC3 Fusion in Glioblastoma
… multi-fusion dataset comprising FGFR3-TACC3, CD74-NRG1, and ESR1-PRKN across multiple HLA alleles, improving predictive robustness and specificity. Functional validation using ELISpot assays demonstrated that 9 of 10 fusion derived in vitro validated binders induced significant IFN-γ secretion …
-
Targeting Innate Immune Memory to Alleviate Monocyte Exhaustion and Chronic Inflammation
… by elevated expression of CD49d, CD86, CD74, and CD38, but these features were not observed during the acute phase. The low-grade inflammation is marked by enhanced monocyte-endothelial adhesion, as oxLDL or cholesterol increases adhesion molecule expression on both cell types. Unlike …
-
Objects, emotions, and the household in Renaissance Prague, c.1570-1620
In recent years, scholars have increasingly recognised that thinking and feeling are not abstract or immaterial processes, but take place through bodies, objects, and the physical environment. This thesis is a contribution to this literature. It examines emotions and the lifecycle in Renaissance …