Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 26 for “"CD73"”.
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Novel Modulators of CD39 and CD73
CD39 and CD73 are crucial in purinergic signalling, converting triphosphate and diphosphate nucleotides such as ATP and ADP into AMP, which CD73 further degrades into adenosine. CD39 and CD73 dysregulation is linked to various diseases. In cancer, their upregulation is associated with immune …
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Inhibition of adenosinergic signaling in the tumor immune environment: the effect of combination CD73 blockade and oHSV therapy on solid tumors
… predominantly the responsibility of ectoenzyme CD73 (<em>NT5E</em>) which catalyzes the hydrolysis of AMP to eADO. High <em>NT5E </em>gene expression, as well as gene signatures suggestive of adenosine signaling, correlated with a significantly worse prognosis for patients with solid tumors. …
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Purinergic Signaling Regulates Filopodia-Induced Zippering
… The present work provides strong evidence that CD73-generated adenosine actively promotes cell-cell adhesion in carcinoma cells by filopodia-induced zippering. Adenosine-generating ecto-enzyme, CD73, was down-regulated in moderately- and poorly-differentiated, invasive, and metastatic …
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Tumour infiltrating T cells in non-small cell lung cancer and their interactions with cancer-associated fibroblasts
… neoplastic cells. CD39 acts in concert with CD73 to generate adenosine and thereby promote immunosuppression in the TME. Previous work from our group has shown that CAFs drive a CD39+CD103- CD4+ and a CD39+CD103+ CD8+ T cell population. This thesis will investigate the expression and spatial …
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Influx and Efflux of Adenine Nucleotides From Erythrocytes Regulate Oxygen Transport and Systemic Metabolism
… Our studies show that the loss of AMPD3 and CD73, two important enzymes in regulating AMP levels intra- and extra-cellularly, respectively, allows for an increase in sustained metabolic activity. We show that this increase in work capacity is linked to an increase in erythrocyte’s …
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Untersuchungen zur Expression von Adenosin-Rezeptoren und Enzymen des Adenosin-Stoffwechsels auf der Oberfläche menschlicher lymphoider Zellen
… Komponenten, wie der Ecto-5´-Nukleotidase (CD73) und der Adenosin-Desaminase (ADA). Diese Rezeptoren sind zudem mit den verschiedensten Signaltransduktionswegen verschaltet. Innerhalb dieser Arbeit sollten mögliche Mechanismen gemeinsamer potentieller Regulationen dieser Komponenten anhand …
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Etablierung einer Zellkultur von PDL-Fibroblasten aus parodontal erkranktem Zahnhalteapparat des Menschen
… unveränderte Expression stellt sich für CD13 und CD73 als Faktoren, welche die Immunantwort modulieren, und für CD44 und CD29 als Adhäsionsmoleküle dar. Die statistische Auswertung der FACS-Ergebnisse ergibt, dass zwischen gesunden und parodontal erkrankten PDL-Zellen für Kollagen Typ I und CD73 …
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Targeting the adenosine pathway reshapes a myeloid-dependent tumour microenvironment in pancreatic ductal adenocarcinoma. An opportunity for therapeutic intervention
… of a molecule of ATP by enzymes called CD39 and CD73. The stimulation of the adenosine receptors by extracellular adenosine on the immune cells has been shown to favour a pro-tumorigenic and tolerogenic microenvironment. Results: Using syngeneic, *in vivo* murine models of PDAC with differential …
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Pre-operative ablative radiotherapy in combination with immunotherapy and novel agents in pancreatic cancer
… radiotherapy and the expression of CD39 and CD73, key ectoenzymes involved in the conversion of ATP to immunosuppressive adenosine, was increased on Tregs and myeloid cells respectively. However, combining ablative radiotherapy with dual PD-L1 and CTLA-4 blockade or CD73 inhibition with or …
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Annexin A1 im chronischen Nierenversagen
… antigen), Makrophagen (CD 68), Fibroblasten (CD73) und Myofibroblasten (alpha-smooth muscle actin (α-sma)). Zellkulturstudien wurden an immortalisierten renalen kortikalen Fibroblasten aus Wildtyp- und Annexin A1-defizienten Mäusen, sowie an etablierten humanen und murinen renalen Fibrolasten …
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The Expression Of Connexin-43 By CD11c+ Dendritic Cells Is Required to Maintain CD4+ Foxp3+ Regulatory T Cell Population in Peripheral Lymphoid Organs
… expression of CD39 and higher expression of CD73, ectonucleotidases mediating T<sub>R</sub> cell immunosuppressive function. We propose that the presence of Cx43 on the surface of dendritic cells is required for effective communication between T<sub>R</sub> cells and dendritic cells so as to …
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T-Bet Expressing B Cells With Distinct Residency And Functional Characteristics Give Rise To Plasma Cells
… after infection, acquire the memory markers CD73, PD-L2 and CD80, and persist indefinitely with limited interconversion between T-bet+ and T-bet- B cell pools. Moreover, T-bet+ B cells are required for HA stalk specific antibodies and sustained protective HAI titers. T-bet+ HA-specific B …
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Metabolism in Vascular Endothelial Cells: Effects of Hyperglycaemia, Pro-Inflammatory Cytokines and Polyphenols
… The inhibition of adenosine deaminase and CD73 activities with physiological cellular concentrations of quercetin was consistent with the elevations observed in adenosine and AMP levels. Conclusions: Quercetin treatments reversed the effects of high-glucose and TNF-α on energy metabolite …
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PI3Kδ in B cell Homeostasis and Transformation
… subset characterised by high expression of CD73. Adoptive cell transfer of CD73hi B cells into immunocompromised mice lead to malignancy after ~100 days, validating the transformation potential of these cells. To evaluate the contribution of T and B cell-intrinsic PI3Kδ hyperactivity on B …
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Efeitos de crises crônicas e agudas induzidas por pentilenotetrazol sobre a hidrólise de nucleotídeos púricos em soro de ratos adultos
… ATP difosfoidrolase (CD39) e 5’-nucleotidase (CD73). Embora esta associação enzimática já esteja bem descrita, o envolvimento da enzima fosfodiesterase não pode ser descartado, uma vez que esta hidrolisa nucleotídeos como ATP e ADP, além de outros substratos. Recentemente, foi demonstrado em …
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The Role of Adenosine Signaling In Mature Erythrocytes and Erythroid Progenitors
… profiling shows for the first time that 1) CD73-dependent elevation of plasma adenosine signaling via erythrocyte specific ADORA2B coupled with AMP-activated protein kinase is a key mechanism for hypoxia adaptation via induction of 2,3-BPG production with O<sub>2</sub> release to counteract …
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The modulation of autoimmune disease progression in mouse models
… approaches, we observed a notable expansion of CD73+ B cells, which exerted an immunosuppressive role and could be responsible for T1D resistance. Next we examined the effect of targeting affinity maturation through these two approaches in lupus-prone mice. The genetic abrogation of AID in BXSB …
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ADP regulation of insulin secretion and beta-cell apoptosis
… revealed the expression of CD39, CD39L1 and CD73. 48 hours treatment of high glucose significantly decreased CD39 gene expression and increased CD39L1 expression. Bioluminescence assays also revealed that high glucose caused VSMCs released of ATP and the ectonucleotidase inhibitor ARC67156 …
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Overcoming wound healing complications following radiotherapy in human breast dermal fibroblasts, through the influence of preadipocytes from the stromal vascular fraction
… cells expressed the preadipocyte markers CD10, CD73 and CD105 and no CD45 (negative marker). SVF cells cultured displayed a typical ASC fibroblastoid morphology. Analysis of the secretome identified the presence of FGF, adiponectin and VEGF, while functional analysis demonstrated a stimulatory …
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