Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 8 of 8 for “"CD70"”.
-
Modulating Immunometabolism to Improve The Activity of Car-Nk Cells Targeting Cd70 In Renal Cell Carcinoma
… develop next-generation CAR-NK cells targeting CD70, a pan-cancer antigen which is overexpressed in multiple tumors, including ccRCC, but with limited normal tissue expression. Our group has designed a novel CAR construct that targets CD70, ectopically produces interleukin (IL)15 to support NK …
-
Gestörte Expression von CD70 und CD86 auf naiven CD27-B-Lymphozyten von Patienten mit Variablem Immundefektsyndrom (CVID)
… CD38) oder der T- B- Zellwechselwirkung (CD25, CD70, CD86) aufwiesen. Wir stimulierten durch Zellsortierung gereinigte naive B- Zellen (CD19+CD27-IgM+IgDhighIgG-IgA-) von 10 CVID- Patienten und 10 gesunden Kontrollen für 4 Tage mit anti- IgM und IL-2 in An- oder Abwesenheit von nicht aktivierten …
-
Reciprocal Regulation of CD4+ and CD8+ T Lymphocyte Effector and Memory Fates by Interleukin 12 and Type 1 Interferon
… of CTL activity through the costimulatory CD27/CD70 pathway. Therefore, taken together, these findings support a novel model in which TCR activation and costimulation act to shape the ability for IL-12 and IFN-a/b to differentially program the development of distinct classes of effector and …
-
Novel immunotherapy for paediatric cancers
… derived from individual patients. High CD86, CD70 and ICOSL was associated with bad CART cell persistence while OX40L and IL10 expression - with good CART cell persistence and delayed CART cell exhaustion. Inclusion of 4-1BB in CAR design reduced CART activation but delayed their exhaustion. …
-
The effect of manipulating apoptotic cell uptake on their immunogenicity
… of costimulatory molecules, CD86 and CD70, when BMDCs were deficient for the inhibitory Fc?R, Fc?RIIb.<br/>Additionally, the immunosuppressive effect of apoptotic cells on antibody production proved dependent on the exposure of PS; whereby both DN-MFG-E8 and DN-MFG-E8-Fc proteins were …
-
To ascertain if blockchain can facilitate the Internet of Things security and scalability requirements
Several consensus algorithms have been proposed as a way of resolving the Byzantine General problem, with respect to the blockchain consensus process. However, when these consensus algorithms are applied to a distributed, asynchronous network, some suffer with security and/or scalability issues, …
-
The idea of solitude: studies in a changing theme, from Pomfret to Wordsworth
The dissertation identifies two major lines of thought within the idea of 'solitude': the theme of retirement, a concern with social setting and environment, leading to retreat to the country; and the theme of isolation, a philosophical concern with individual identity and relationship with the …