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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

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Showing 1 to 20 of 51 for “"CD68"”.

  1. CD68-positive tumour associated macrophages, PD-L1 expression, and EBV latent infection in a high HIV-prevalent South African cohort of Hodgkin lymphoma patients

    Antel, Katherine RaeDepartment of Medicine2021

    Background and aims A higher proportion of CD68-positive tumour associated macrophages (TAMs) has been associated with poorer outcomes in HIV-negative patients with Hodgkin lymphoma (HL), but whether this is true in HIV positive patients with HL is not known. In this study, we investigated the …

    cape-town Repository record

  2. The impact of Wnt5a signaling and tumor associated macrophages in breast cancer

    Hagerling, CatharinaDepartment of Laboratory Medicine, Lund University2012

    … been reported to recognize M2 macrophages, while CD68, on the other hand, is a frequently used pan-macrophage marker that recognizes both pro-inflammatory M1 macrophages and anti-inflammatory M2 macrophages. We evaluated CD163 as a TAM marker in human breast cancer and compared it to CD68. We …

    lund Repository record

  3. Neuroprotective and immunomodulatory properties of the new PPARγ agonist MDG548: an in vitro and in vivo study in PD models

    LECCA, DANIELAUniversità degli Studi di Cagliari2016

    … by fluorescent immunohistochemistry for CD68. MDG548 arrested dopaminergic cells degeneration in the SNc in both the subacute MPTP and the chronic MPTPp models of PD, and reverted MPTPp-induced motor impairment. Moreover, MDG548 reduced microglia activation, iNOS and TNF-α production, …

    cagliari Repository record

  4. Avaliação plasmática, histológica e imunohistoquímica de biomarcadores da aterosclerose humana precoce e crônica

    Leal, Ana Karina SouzaFaculdade de Farmácia2017

    … risk markers and receptors for LDL-r, CD36 and CD68 in fragments and internal thoracic aorta was determined. Results. Lipid profile data between groups said as chronic (> 56 years) and said as precocious (<56 years) were different (p <0.05). The indices in the group <56 years were above the …

    brazil-ufba Repository record

  5. Stromal components and the control of lymphocyte trafficking in human lymph nodes

    Park, SaemResearchSpace@Auckland2015

    … Our data for the first time demonstrate that CD68+ antigen presenting cells (APCs) in the T cellrich parenchyma of human LNs are the main cell population expressing SGPL1. In vitro-derived CD68+SGPL1+ APCs were able to internalise and irreversibly degrade S1P, and this activity was inhibited …

    auckland-ms Repository record

  6. Acute tubulo-interstitial nephritis : clinical profile and pathogenic mechanisms

    Elmedhem, Abdurrezagh MansurUniversity of Birmingham2010

    … staining for CD3+ cells, CD4+ cells, CD8+ cells, CD68+ cells, eotaxin, CCR3, VCAM-1, IL-4 and eosinophil proteins. These results suggest that there is a Th 2 type of inflammatory and immune response in acute tubulointerstitial nephritis. Comparison between the infiltrating cells showed no …

    birmingham Repository record

  7. The role of tissue inflammation in Kenyan women with breast cancer

    Abdulrehman, Shahin SayedDepartment of Pathology2022

    … with immunohistochemistry for CD3, CD4, CD8, CD68, CD20 and Fox P3, scanned and analysed on the Leica Aperio platform. Cytokine profiles of ER positive and Triple Negative BC were performed using microarray gene arrays and results validated with the ELISA platform. Multivariable polytomous …

    cape-town Repository record

  8. Development of 3D multicellular liver organoids derived from human induced pluripotent stem cells to model antiretroviral therapy induced liver injury

    Maepa, Setjie WelcomeDepartment of Integrative Biomedical Sciences (IBMS)2025

    … markers. Flow cytometry using EpCAM, CD166 and CD68 antibodies indicated that HLOs comprise of 60,4% EpCAM+ cells, 11,2% EpCAM-/CD166+ cells and 5% EpCAM-/CD68+ cells, respectively. HLOs exhibited high CYP3A4 enzyme activity compared to HepaRG 3D model. Proinflammatory (IL-6, IL-1β and TNF-α) …

    cape-town Repository record

  9. The role of the microglial P2Y₆ receptor in ageing, development, and tauopathy

    Dundee, JacobUniversity of Cambridge2023

    … internalisation of synaptic material within CD68+ lysosomes in Iba1+ microglia in P30 *P2ry6⁻´⁻* mice. This indicates that P2Y₆R-dependent phagocytosis of synapses contributes to synaptic loss late in development. *In vitro*, P2Y₆R deficiency reduced microglial phagocytosis of myelin debris. …

    cambridge Repository record

  10. Macrophage Polarization (M1/M2) and its Role in Wnt5a Secretion/Expression in Atherosclerosis

    Seelamneni, HarshaOhio University2013

    … immunohistochemical analysis using Wnt5a, CD68 (for macrophages) and CD163 (for M2 macrophages) in human atherosclerotic tissue sections derived from the carotid arteries of patients undergoing endarterectomy. We also performed immuno-fluorescence analysis to detect Wnt5a in human …

    ohiolink Repository record

  11. Influence of body weight gain on insulin regulation, adipose tissue inflammation and lipid metabolism in equines

    Blaue, Dominique DorisUniversität Leipzig

    … in serum. Levels of inflammatory parameters (CD68, IL-1β, IL-6, TNFα) and markers of lipid metabolism (FABP4, LPL) were analyzed in AT samples by RT-qPCR. The project was approved by the Ethics Committee for Animal Rights Protection of the Leipzig District Government (No. TVV 32/15). Data were …

    qucosa-diss

  12. Identificación de factores biológicos asociados con la afectación del ganglio centinela y/o los ganglios no centinela en el cáncer de mama

    Beridze Vaktangova, Nana2014

    … mostraron que la presencia elevada de células de CD68 positivas y CD138 positivas (macrófagos y células dendríticas, respectivamente), se relaciona con una mayor probabilidad de afectación tumoral del ganglio centinela. Asimismo la expresión de MMP1 por las CMIs peritumorales del ganglio centinela …

    oviedo Repository record

  13. Atherosclerotic inflammation imaging using somatostatin receptor-2 positron emission tomography

    Tarkin, Jason MichaelUniversity of Cambridge2017

    … ligand binding to SST2 receptors occurred in CD68-positive macrophage-rich carotid plaque regions, and (iii) and carotid SSTR2 mRNA was highly correlated with both the pan-macrophage marker CD68 and in vivo 68Ga-DOTATATE PET signals. In clinical imaging, increased 68Ga-DOTATATE inflammatory …

    cambridge Repository record

  14. Analysing the relationship between immune infiltration and tissue architecture in high grade serous ovarian cancer

    Barker-Clarke, RowanUniversity of Cambridge2021

    … cytotoxic T-cells, CD45RO+ memory T-cells and CD68+ macrophages. The stromal infiltration of CD68+ (HR = 0.44, p = 3×10−4 ) and CD45RO+ (HR = 0.76, p = 7×10−4 ) cells was positively associated with survival and the positive prognostic value of CD8 + cells increased when the density was averaged …

    cambridge Repository record

  15. Targeting MERTK on tumour cells and macrophages: a potential intervention for sporadic and NF2-related meningioma and schwannoma tumours

    Herrera Keane, Kevin2025

    … MERTK, as well as macrophage markers CD163 and CD68, are highest in passage zero of schwannoma and meningioma primary cells. Drug treatment and immunocytochemistry experiments revealed that inhibition of MERTK by the small-molecule inhibitor UNC2025 reduces the number of tumour cells and …

    plymouth Repository record

  16. Immunzellen in primären und metastasierten gastrointestinalen Stromatumoren (GISTs)

    Gieselmann, Marieke Dorothea2012

    … Zellen (Kim-1P) und Zellen der Makrophagenlinie (CD68) zu bestimmen. Außerdem wurde die Anzahl verschiedener Lymphozyten (T-Lymphozyten: CD3, B-Lymphozyten: CD20, NK-Zellen: CD56) in diesen Proben untersucht. Hierzu wurden die Paraffinblöcke der Exzisionspräparate oder der Stanzbiopsien mit Hilfe …

    goettingen Repository record

  17. Borrelienneuropathie - eine histologische und immunhistochemische Charakterisierung

    Neukirchen, SebastianUniversität Würzburg

    … Färbungen wurden mit Antikörpern gegen Leu4, CD68, 27E10 (frühzeitig aktivierte Makrophagen) und 25F9 (späte Makrophagen), Membrane-Attack-Komplex C5b-9, Adhäsionsmolekül ICAM sowie inflammatorische Zytokine Tumor Nekrose-Faktor-alpha (TNF-alpha), Interleukin-1ß (IL-1ß) und Interleukin-6 …

    wurz-thes Repository record

  18. Zytologie und Immunozytochemie von Mesothelzellen im Ergüssen

    Xiaohong, Wu

    … CEA-Antigens, den makrophagenspezifischen Marker CD68 und einen Antikörper zum Nachweis einer Proliferationsaktivität (MIB-1). Die Auswertung erfolgte zum einen qualitativ (Zellklassifizierung und Charakterisierung), zum anderen quantitativ (Zellzahlbestimmung). Die quantitativen Ergebnisse wurden …

    freiburg-diss Repository record

  19. Immunomodulatory Roles of the Lysosomal Sialidase Neuraminidase 1

    Fremuth, Leigh Ellen2024

    … microglial phagocytic receptors, we identified CD68 as a substrate of Neu1 and showed that Trem2 homeostasis is altered in Neu1 KO microglia. In these cells, Trem2 is abnormally sequestered into endo-lysosomal vesicles, wherein sialylated Trem2 accumulates in lysosomes, promoting excessive …

    tenn-hsc Repository record

  20. Tumor de células granulares, una neoplasia de histología infrecuente y usualmente benigna de la mama

    Duque Ortiz, Jesús DavidUniversidad del Rosario2025

    … al 1%. Las pruebas inmunohistoquímicas para CD68, S100 y enolasa fueron positivas sugiriendo origen neuroectodérmico, mientras que resultaron negativas para CKAE 1-3, desestimando carcinoma. Conclusiones: Dada su presentación como variante inusual en mujeres, este caso brinda información del …

    rosario Repository record

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