Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 20 for “"CD56"”.
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Investigating the role of CD56⁻ ‘atypical’ NK cells in Gambian children with asymptomatic malaria
… symptomology in malaria infection. Among these, CD56- NK cells, considered ‘atypical’ NK cells due to a lack of canonical CD56 expression, have shown enhanced cytotoxic potential against malaria parasites and may contribute to anti-malarial immunity. Although CD56- NK cells are less …
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Cd56-Specific T Cells: Using Genetically Engineered T Cells to Redirect Specificity to A T Cell Expressed Antigen
<p>The CD56 antigen is expressed on several deadly malignancies currently lacking long-term efficacious therapies. Chimeric antigen receptor (CAR) based immunotherapies have shown both safety and efficacy and even a curative ability in clinical trials, laying the foundation for applying CARs to new …
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Die Bedeutung von Granzym A, B, K und Perforin bei gesunden Personen und in der Pathogenese chronischer Lungenerkrankungen
… zytotoxischen Proteine von CD3+, CD4+, CD8+ und CD56+ Zellen gespeichert. Es wurde hauptsächlich von Lymphozyten der T-Zell-Linie exprimiert im Gegensatz zu Perforin und Granzym B, die eher in CD3- Zellen enthalten waren. Die Verteilung von Granzym A erschien ausgeglichener. Überraschenderweise …
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Selezione e processazione di cellule Natural Killer da donatore aploidentico "KIR-ligand" incompatibile per l'immunoterapia adottiva di pazienti con Leucemia Acuta Mieloblastica ad alto rischio
… CD3+ T cells followed by positive selection of CD56+ NK cells. CD56+ cells were enriched from 7,70% (1,26-11,70) to 93,50% (66,41-99,20) (median recovery 53,05% (30,97-72,85), median T-depletion 3,03 log (2,15-4,52) viability >92%) and their citotoxic activity was inalterate. All patients (4 …
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Circulating Natural Killer Cells and Natural Killer Receptor Positive T Cells In Patients with Hepatitis C
… 13.7% for NK cells; p<0.001 and 1.3% vs 3.7% for CD56+ T cells; p=0.0001). NK cells and CD56+ T cells were also depleted in HCV resolvers compared to controls. The frequencies o f expression o f CD16, CD56, CD161, KIR2DL1 and KIR3DL1/S1 by T and non-T cells were also altered in chronic HCV …
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Cellular Immune Changes in the Peripheral Blood of Subjects Chronically Infected with XMRV
… CD45+ CD3- lymphocytes, CD45+ CD3- CD19- CD56+ NK cells and CD19+ B cells. Moreover, the NK phenotype in XMRV+ patients was altered, with 80% of XMRV+ patients having a significantly reduced CD56DIM population. Within this CD56DIM population present in XMRV+ patients, only 40% express …
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A Flow Cytometric Analysis of Immunocyte Populations in Peripheral Blood and Pleural Effusions of Patients with Cancer
… in the PE compared to the levels in the PB. CD16+CD56+ cells were lower in the PE versus PB. CD4+CD8+ cells, which represent a subset of activated T cells, were increased in the PE. Activation markers revealed that only a few pleural T cells were positive for CD25, while there was a significant …
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Differential Expression of T Cell Immunoglobulin- and Mucin-Domain-Containing Molecule-3 (TIM-3) According to Activity of Behçet's Disease
… of TIM-3 as well as CD4, CD8, CD11b and CD56 in peripheral blood mononuclear cells (PBMC) was assessed by flow cytometry. BD group was divided according to the disease activity. TIM-3 expression was also compared between BD in active state and BD in remission state. Western blot analysis …
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Integrative Approaches in Colorectal Cancer: Prognostic Biomarkers and AI-Driven Hypothesis Generation for Early Diagnosis and Drug Resistance
… negative correlation between TP53 and CD56 mutations, which have opposing effects on patient survival. TP53, a tumor suppressor gene, is frequently mutated in CRC, while CD56, a glycoprotein involved in cell adhesion, may act as a cancer enhancer. Immunohistochemical (IHC) analysis of …
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Immunzellen in primären und metastasierten gastrointestinalen Stromatumoren (GISTs)
… CD3, B-Lymphozyten: CD20, NK-Zellen: CD56) in diesen Proben untersucht. Hierzu wurden die Paraffinblöcke der Exzisionspräparate oder der Stanzbiopsien mit Hilfe eines manuellen Tissue-Arrayer in einem Empfängerparaffinblock (TMA) nebeneinander in 22 TMAs aufgereiht. Die Fotographien …
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The significance of aberrant phenotypes and multidrug resistance for evaluation of the dynamics of minimal residual disease in acute leukemia patients /
… with acute myelogenous leukemia (CD13+CD33+CD56+, CD5+, CD7+) are related to an increased multidrug resistance and through this mechanism influence a higher level of minimal residual disease. Aberrant phenotypes of patients with acute lymphoblastic leukemia did not correlate with parameters …
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Soy Isoflavone Supplementation Does Not Alter Distribution of Circulating Lymphocytes or Natural Killer Cell Activity in Postmenopausal Women
… (CD19+) and natural killer (NK) cells (CD16+CD56+) via flow cytometry. Cytotoxicity of NK cells was quantified based on lactate dehydrogenase release of lysed K562 cancer cells following co-culture with NK cells from subjects. Analysis of plasma isoflavone concentrations by HPLC demonstrated …
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Modulation of immune responses by human paraininfluenza virus
… that T cell proliferation control was due to CD56+ natural killer (NK) cells. Of interest, the regulation was not exerted by NK cytotoxicity but by partial arrest of cell cycle progression via regulation of p27 cyclin dependent kinase (cdk) inhibitor. Moreover, there was an overall control of …
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Sergančiųjų ūmine leukemija aberantinių fenotipų ir dauginio atsparumo vaistams nustatymas ir svarba vertinant minimalios liekamosios ligos dinamiką /
… with acute myelogenous leukemia (CD13+CD33+CD56+, CD5+, CD7+) are related to an increased multidrug resistance and through this mechanism influence a higher level of minimal residual disease. Aberrant phenotypes of patients with acute lymphoblastic leukemia did not correlate with parameters …
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Sex as a Biological Variable in Preclinical Animal Studies with an Infectious Disease Exemplar.
… stable peripheral populations (CD45, CD4, CD8, CD56, CD123), with a hormone-dependent increase in CD45 expression associated with elevated estradiol levels. Vaginal microbiota composition remained stable across individuals, with increases in Mobiluncus spp. observed only during peak progesterone …
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Differential expression of beta 2 integrins in Korean Behcet’s disease patients
… CD11b, CD11c, as well as CD4, CD8, CD18 and CD56 in peripheral blood mononuclear cells was assessed by flow cytometry. The transcriptional level expression of CD11a and CD11c was assessed by reverse transcription polymerase charin reaction.Western blot analysis was performed to evaluate CD11a …
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Engineering of next-generation chimeric antigen receptors based on alternative binding domains
… that of primary peripheral NK cells (CD3- CD16± CD56+). Although YT cells display natural cytotoxicity against B cell lymphoma cells, this activity is further enhanced by transduction of anti-CD19 CARs, highlighting the suitability of this novel cell platform for next-generation CAR-NK cell …
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IDENTIFICATION OF NCAM1 AS A NOVEL PROGNOSTIC PROSTATE CANCER STEM CELL BIOMARKER
… neural cell adhesion molecule (NCAM1/CD56), a known marker of neuroendocrine (NE) cells, as a novel PCSC marker that provides prognostic information and molecular insights into the process of tumorigenesis. NCAM1 defines clusters of cells enriched in proliferative inflammatory atrophy …
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UNVEILING HUMAN NATURAL KILLER CELLS ONTOGENESIS IN HOMEOSTATIC CONDITIONS AND DURING THE IMMUNE RECONSTITUTION AFTER HAPLOIDENTICAL HEMATOPOIETIC STEM CELL TRANSPLANTATION
… also for NK cells. additionally, we highlight cCD56bright NK cells as driver of NK cell differentiation both in vitro and in silico. This is true also for the process of IR after h-HSCT, where cCD56bright are accompanied by expanded unCD56dim that concur to the generation of more differentiated …
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Do money managers outperform their respective benchmark? Evidence from South African Unit Trust industry
Motivated by the growing attraction of the mutual fund industries across the world, this research seeks to explore the economic benefits contributed by the South African equity unit trust managers over the period from 1 January 2002 to 2 September 2012. The performance is examined over two …