Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"CD47-Blockade"”.
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Leveraging Innate Immune Sensors to Generate Durable Anti-Glioma Adaptive Immune Responses
… of the antiphagocytic “don’t eat me” ligand CD47. Here we tested whether activation of multiple conserved innate immune pathways could initiate proinflammatory conversion of suppressive myeloid populations, activation of antigen presenting cells, and priming of anti-glioma adaptive immune …
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Anti-CD47 targeting therapy for the treatment of colon and pancreas cancers.
CD47 is a "don't eat me" signal over expressed on cancer cells inhibiting their engulfment by phagocytes. A novel monoclonal antibody, Hu5F9-G4, blocking CD47's interaction with its ligand SIRPα allowed for phagocytosis of colorectal and pancreas tumors by macrophages. In some models, treatment of …
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Strategien zur Verstärkung der antikörpervermittelten Effektorzellaktivierung beim Multiplen Myelom
… (SIRP) α auf Makrophagen und seinem Liganden CD47 blockiert. Dara-DE und SIRPα-Fcσ wurden mit rekombinanter DNA-Technik generiert, in eukaryoten Zellen exprimiert, gereinigt, charakterisiert und hinsichtlich ihrer in vitro Zytotoxizität analysiert. Dara-DE erwies im Vergleich zu Daratumumab …