Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 26 for “"CD47"”.
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Discovery of Anti-CD47 Peptides for Cancer Immunotherapy and CD47-mimicking Peptides That Inhibit Phagocytic Clearance of Nanoparticles
… and both phagocytes and natural killer cells. CD47 is overexpressed in various cancers which act as a potent ‘do not eat me’ signal that contributes to immune evasion of cancer cells. Innate checkpoint inhibitors including CD47/SIRPα antagonists, are now being developed as new strategy for …
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Role of CD47 In Red Cell Apoptosis (Eryptosis)
CD47 is a 47-52 kDa membrane spanning glycoprotein, which has 5 known isoforms and is a member of the immunoglobulin superfamily (IgSF). It possesses a large extracellular N-terminal IgV like domain. CD47 acts as a ‘do not eat me’ signal and consequently as a marker of self. Moreover, CD47 is …
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Cd47+ Exosomes Facilitate Effective Targeting of Oncogenic Kras In Pancreatic Cancer
… as compared to liposomes, which is mediated by CD47, a widely expressed integrin associated transmembrane protein found on exosomes. We also reveal the role of macropinocytosis in aiding the entry of exosomes into oncogenic Ras mutant pancreatic cancer cells. Overall, our results inform on a …
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Anti-CD47 targeting therapy for the treatment of colon and pancreas cancers.
CD47 is a "don't eat me" signal over expressed on cancer cells inhibiting their engulfment by phagocytes. A novel monoclonal antibody, Hu5F9-G4, blocking CD47's interaction with its ligand SIRPα allowed for phagocytosis of colorectal and pancreas tumors by macrophages. In some models, treatment of …
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Chimeric Thrombomodulin and CD47 proteins synergistically improve the engraftment of islets by mitigating IBMIR
… immunological ligands, Thrombomodulin (TM) and CD47, on the surface of islets to promote islet engraftment by controlling thrombotic/inflammatory reactions associated with an immediate blood-mediated inflammatory response (IBMIR). In chapter 3, syngeneic pancreatic islets are engineered with a …
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Atr-Mediated Cd47 and Pd-L1 Upregulation Restricts Radiotherapy-Induced Immune Priming and Abscopal Responses In Colorectal Cancer
… pathway — ATR/Chk1/STAT3 — to upregulate both CD47 and PD-L1 in response to radiotherapy, which through engagement of SIRPα and PD-1 suppresses the capacity of antigen-presenting cells to phagocytose them thereby preventing TAA cross-presentation and innate immune activation. This …
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The Development Of Multivalent Nano-Self Peptides As Antagonists For Antibody-Dependent Macrophage Phagocytosis
… important interaction between membrane protein CD47, present on all ‘self’ cells, and the macrophage immune-receptor SIRPα. Upon binding to CD47, SIRPα delivers “do not eat me” signals to the macrophage allowing the contact cell or particle to evade engulfment. Cancer cells, which are abnormal …
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The role of signal regulatory protein alpha in regulating macrophage subset activity in homeostasis and inflammation
… regulatory protein alpha (SIRPα), receptor to CD47. Characterised as a “don’t eat me” signal, SIRPα-CD47 ligation negatively regulates Mφ phagocytic activity. This study developed a co-culture system between CD47+ HL-60 and K562 cells, and SIRPα+ Mφ subsets in order to investigate whether the …
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Identification of tumour microenvironment-derived signals that modulate the development and functionality of MDSCs
… MDSCs, focusing mainly on the role of the SIRPα-CD47 signalling axis. In an orthotopic melanoma model, we observed an increase in Ly6C-expressing myeloid cells (indicating monocytic-myeloid derived suppressor cells (M-MDSCs) and monocytic dendritic cells (moDC)) as tumours developed. These cells …
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Alpha v beta 5 and related receptors in human B lymphocyte development
… This integrin can form a signalling complex with CD47. Ligation of CD47 by anti-CD47 antibodies induces apoptosis in some cell lines. To determine whether a pattern exists between response to this stimulation and expression of αvβ3 integrin, cell lines with and without the integrin were tested. It …
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Crosstalk between colorectal cancer cells and tumour-associated macrophages
… of extracellular matrix (ECM) occurs in CRC. CD47 binding to α2β1 integrin could regulate cyclooxygenase-2 expression and cell migration on collagen I surface in intestinal epithelial cells. CD47 is involved in crosstalk between colon cancer cells and macrophages by interacting with its ligand …
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INSIGHTS ON THE CROSSTALK BETWEEN THE IMMUNE SYSTEMAND CANCER: IMMUNE CHECKPOINT MOLECULES AND LYMPHOIDPOPULATIONS ASSESSMENT IN CANINE ROUND CELL TUMORS
… (2) the expression and prognostic role of CD47 in canine leukemias, and (3) the characterization of lymphocyte populations in peripheral blood and sentinel lymph nodes (SLNs) of dogs with mast cell tumors (MCTs). Regarding PD-L1, the project evaluated the expression of the surface membrane …
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Leveraging Innate Immune Sensors to Generate Durable Anti-Glioma Adaptive Immune Responses
… of the antiphagocytic “don’t eat me” ligand CD47. Here we tested whether activation of multiple conserved innate immune pathways could initiate proinflammatory conversion of suppressive myeloid populations, activation of antigen presenting cells, and priming of anti-glioma adaptive immune …
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Involvement of eicosanoid signalling in epithelial cell migration
… shown to be mediated through the activation of CD47 and its associated G_i3 protein, which in turn lead to protein kinase C_, the Ras GTPase and NF_B activation. COX-2 expression is synonymous with activation of the protein. Inhibition of COX-2 expression or specifically inhibiting COX-2 …
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In Vivo Genetic Screening to Identify Mechanisms of Resistance to Cancer Immunotherapy
… to be expressed by cancer cells such as PD-L1, CD47 and IDO1. Although cancer cells could use many more genes to evade detection by the immune system, methods to systematically identify such genes are lacking. To discover new immunotherapy targets, we developed a pooled, loss-of-function in vivo …
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Strategien zur Verstärkung der antikörpervermittelten Effektorzellaktivierung beim Multiplen Myelom
… (SIRP) α auf Makrophagen und seinem Liganden CD47 blockiert. Dara-DE und SIRPα-Fcσ wurden mit rekombinanter DNA-Technik generiert, in eukaryoten Zellen exprimiert, gereinigt, charakterisiert und hinsichtlich ihrer in vitro Zytotoxizität analysiert. Dara-DE erwies im Vergleich zu Daratumumab …
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The Relevance of the SIRP Protein Family to Signal Transduction and Cell Adhesion
… properties. This led to the identification of CD47 as one ligand for SIRP α, performed in collaboration with others21and confirmed here. Furthermore, these experiments suggested that SIRP α molecules have at least one further unknown ligand that is not CD47. The discovery that SIRP α was a cell …
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THE ROLE OF IL-¿¿1 RECEPTOR-¿¿ASSOCIATED KINASE 4 IN MICROGLIAL ACTIVATION IN ALZHEIMER’S DISEASE
… a cell surface receptor ensemble including CD36, CD47, SRA, ¿¿6¿¿1 integrin, TLR2, TLR4, TLR6, and CD14. The role of individual TLRs in the microglial response to A¿¿ has been controversial. Therefore we elected to inactivate the first kinase activated after TLR ligation, interleukin-¿¿¿1 …
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Erythrocytes derived microvesicles : their characterisation and potential role as delivery vectors
… confirms their parent cells and the presence of CD47 suggests how eMV may avoid phagocytosis. Surface receptors including CD36, CD58 and CD63 indicate how they may communicate and enter the neighbouring cells through endocytosis. The identification of proteases suggests how eMV may be capable of …
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A Signal to Divide: Apoptotic Extracellular Vesicles as Carriers of Mitogenic and Immunogenic Signals
… Surface proteins such as Wnt3a, MIF, and CD47 are identified in bcAEVs. Functional studies demonstrate that bcAEVs enhance proliferation of recipient MDA-MB-231 cells, with Wnt signaling implicated in this process.</p> <p>Overall, my results suggest that the contents of apoptotic …
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