Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 47 for “"CD40L"”.
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Studies of the Mechanisms of Reverse Signaling by CD40L
<p>CD40 ligand (CD40L) is a transmembrane protein expressed on activated CD4 T cells, traditionally known for its role in forward signaling by engaging CD40 on antigen- presenting cells to promote immune activation. While this pathway is well characterized, there is evidence that CD40L also …
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Tumor-Bearing Host Macrophage Dysfunction: Role of CD40/CD40L Interactions
… growth. An interaction between CD40 on Mfs and CD40L on T cells is required for cell-mediated inflammatory responses. The CD40/CD40L interaction is bi-directional; suppressed expression of either protein by the tumor will prevent activation of both Mfs and T cells. We showed that tumor growth …
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Μελέτης της έκφρασης του CD154 (CD40L) στα Τ λεμφοκύτταρα ασθενών με ψωριασική αρθρίτιδα
Το CD40L είναι ένα συνδιεγερτικό μόριο και αποτελεί πρώιμο δείκτη ενεργοποίησης του Τ λεμφοκυττάρου. Υπάρχουν δεδομένα που υποστηρίζουν την υπόθεση ότι τα ενεργοποιημένα Τ λεμφοκύτταρα πιθανώς παίζουν ρόλο στην παθογένεια της ψωριασικής αρθρίτιδας (ΨΑ). Μελετήσαμε συνολικά 12 ασθενείς με ΨΑ, 6 …
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In Vitro Studies of the Anti-Leukaemic Activity of Bezafibrate and Medroxyprogesterone Acetate Against Chronic Lymphocytic Leukaemia
… in activated T helper (TH) cells that express CD40L and secrete IL-4. Like normal B cells, CLL cells interact with TH via their expression of CD40 and receive signals from IL4. This stimulation provides the signal for B cells to divide, as well as protecting them from apoptotic stimuli. …
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Influence of Anti-CD44 on Murine B Cell Activation
… cross-linking on murine B cell activation via CD40L/IL-4 was explored using the anti-CD44 mAbs RK3G9 and IM7. Immobilized RK3G9 and IM7 could strongly inhibit B cell proliferation and Ig production, with IgE inhibition being prominent. Soluble anti-CD44 had no effect. The inhibitory effect of …
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Contact-Dependent Activation of Macrophages by Naive CD4<sup>+</sup> T cells.
… T<sub>H</sub>P cells express high levels of CD40L that is sustained following extended periods of TCR/CD3 stimulation. CD40L is the major T cell molecule involved in contact-dependent signaling of both B-cell and macrophage effector functions. This suggests that naive CD4<sup>+</sup> T cells …
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Transcription factor regulation of T helper subset function
… of the cytokine IL-21 and the surface protein CD40L in T cells that lacked PU.1 expression and resulted in increased numbers of germinal center B cells and antigen-specific antibody titers compared to control mice. The increased germinal center B cells and antibody titers were attenuated with …
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B Cell Signaling and Bioinformatics: Revealing Components of the MHC Class II Antigen Processing and Presentation Pathway
… for Cellular Signaling (AfCS): 1) the BAFF/CD40L project, which evaluates the effects of BAFF and CD40L on primary mouse B cells in long-term cultures, and 2) the B cell single ligand screen project, which evaluates the effects of 32 single ligands on primary mouse B cells in short-term …
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The role of cellular micro-RNAs in Epstein-Barr virus induced cellular transformation and oncogenesis
… with EBV or stimulated to proliferate with CD40L and IL4. This revealed that a large proportion of miRNAs and genes differentially regulated by EBV and not by CD40L/IL4 were modulated by EBV interaction with its CD21 receptor complex, but these changes were maintained or amplified in LCLs; …
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Biochemische und Molekularbiologische Charakterisierung der Wechselwirkungen zwischen Humanen Thrombozyten und Endothelzellen
… Moleküle P-Selektin und CD40 Ligand (CD40L) aus intrazellulären Speicherorganellen auf die Thrombozytenoberfläche. P-Selektin und CD40L werden auf aktivierten Thrombozyten exprimiert und sind direkt an der Interaktion von Thrombozyten mit Leukozyten und Endothelzellen beteiligt. Um die …
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THE CRITICAL ROLE OF CD4+ TH CELLS IN CD8+ CTL RESPONSES AND ANTI-TUMOR IMMUNITY
… a later phase. Through enhanced IL-2, CD80 and CD40L singnaling, and weaker peptideMHC I (pMHC) signaling, Th-APCs stimulated naïve CD8+ T cells to differentiate into effector CTLs, capable of developing into, central memory CTLs. Th-APC-stimulated CD4+ T cells behaved like Th cells in function, …
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The vascular and anti-inflammatory activity of Cyanidin-3-Glucoside and its metabolites in human vascular endothelial cells
… and cluster of differentiation 40 ligand (CD40L) stimulated expression of vascular cell adhesion molecule-1 (VCAM-1) and interleukin-6 (IL-6) in endothelial cells. Here, significant bioactivity of C3G metabolites was observed, as 7 out of 12 of the tested treatments reduced CD40L-induced …
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Insights into the Iimmune Mechanisms Leading to Lupus-like Autoimmunity in New Zealand Black Mice
… Chapter 2 identifies the critical role of CD40-CD40L interactions in the pathogenesis of disease in NZB mice. We showed that this interaction is required for the production of class-switched IgG autoantibodies and development of hemolytic anemia and kidney disease. Polyclonal B cell activation, …
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Characterization of human IgA-inducing protein
… agonists (3,4,5, and 9), other factors including CD40L, GM-CSF, and IL-4, and the neuropeptide vasoactive intestinal peptide (VIP). Under in vitro stimulation with VIP and CD40L, IGIP mRNA expression was up-regulated as much as thirty five-fold above non-stimulated samples within 12-48 hours. …
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Re-Designing Cancer Immunotherapy to Enhance Anti-Tumor Immunity
… T cells inside the TME. Combined α-CD3 and CD40L rather than CD80 leads to superior anti-tumor efficacy compared to either alone. Mechanistically, TCR activation of pre-existing CD8+ T cells synergizes with CD40L activation of DCs inside the TME to control tumor growth. We found exogenous …
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Rac1 signaling regulates platelet-dependent inflammation abdominal sepsis
… First, Rac1 controls surface mobilization of CD40L on activated platelets and second, Rac1 regulates MMP-9 secretion from neutrophils. Our data indicate that inhibition of Rac1 signaling might be a useful target in order to control pathological secretion and shedding of CD40L into the systemic …
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Multiple sclerosis associated SNPs influencing B cell expression of co-stimulatory receptors and T cell responses
… from these samples and then activated these with CD40L-transfected L cells. In line with the ex vivo results, I found that the expression of CD86 and CD40 remained associated with the genotypes of the respective MS associated variants. I then went on to investigate the effects of these stimulated …
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Targeted therapies in mantle cell lymphoma
… investigated how abnormal expression of CD40/CD40L and Fas/FasL along with bcl-2 family members contributes to B cell clonal expansion and influences Rituximab-mediated cell death in MCL models. Rituximab is a chimeric monoclonal antibody targeted against B cells and both Rituximab-sensitive …
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CD40 stimulation activates ‘post-activated’ B Cells which are hyporesponsive to B Cell receptor and toll-like receptor 9 stimulation in autoimmunity
… with the BCR [22-25]. T cell help by CD40-CD40L binding drives germinal center (GC) reaction and the development of long term (auto)-immune B cell memory and is further known to augment BCR signaling via Syk [26, 27]. To draw a more general picture of B cell activation in autoimmunity, this …
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