Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 94 for “"CD40"”.
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Engineered Anti-CD40 Agonist Antibody for Cancer Vaccine Delivery
… immune responses. We synthesized an anti-mouse CD40 agonistic–monovalent streptavidin fusion antibody (αCD40-mSAs), which enables targeted delivery of biotinylated neoantigen peptides to APCs in draining lymph nodes (dLNs). αCD40-mSAs were validated for mSA expression and demonstrated strong …
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Tumor-Bearing Host Macrophage Dysfunction: Role of CD40/CD40L Interactions
… survival and growth. An interaction between CD40 on Mfs and CD40L on T cells is required for cell-mediated inflammatory responses. The CD40/CD40L interaction is bi-directional; suppressed expression of either protein by the tumor will prevent activation of both Mfs and T cells. We showed that …
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Untersuchungen zur CD40 induzierten Expression von A1 in B-Lymphozyten der Maus
… Apoptose. Eine gleichzeitige Stimulation über CD40 bewirkt die Aufrechterhaltung der Proliferation und schützt die Zellen vor programmiertem Zelltod. In der vorliegenden Arbeit konnte gezeigt werden, dass Stimulation über CD40 die Genexpression von A1 - einem antiapoptotischen Mitglied der …
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Role of the CD40 receptor/CD154 ligand dyad in the control of smooth muscle cells phenotype
… Transmigration in die Gefäßwand gekennzeichnet. CD40, ein Mitglied der Tumornekrosefaktor-Rezeptor- Familie das von Leukozyten wie auch von Endothelzellen exprimiert wird, spielt eine wichtige Rolle bei diesem Prozess. Nach ihrer Auswanderung in die Gefäßwand kommen die Leukozyten mit den glatten …
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Suppression of NK cell-mediated cytotoxicity and immunoenhancement of CD40 ligand against porcine reproductive and respiratory syndrome virus
Porcine reproductive and respiratory syndrome virus (PRRSV) is one of the most economically important pathogenics affecting swine industry worldwide. PRRSV is a single-stranded and positive sense RNA virus that belongs to the family of the Arteriviridae (genus Arterivirus). PRRSV has a restricted …
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Identification and functional characterization of novel receptor ligands of CD40 and alpha(v) beta(3) integrin: implications for gene delivery
Thesis (Ph.D.)--University of Rochester. School of Medicine & Dentistry. Dept. of Microbiology and Immunology, 2002.
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CD40 stimulation activates ‘post-activated’ B Cells which are hyporesponsive to B Cell receptor and toll-like receptor 9 stimulation in autoimmunity
… together with the BCR [22-25]. T cell help by CD40-CD40L binding drives germinal center (GC) reaction and the development of long term (auto)-immune B cell memory and is further known to augment BCR signaling via Syk [26, 27]. To draw a more general picture of B cell activation in autoimmunity, …
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Funktionelle und genetische Analyse des Latenten Membranproteins 1 des Epstein-Barr Virus
… und dabei analoge Funktionen zum zellulären CD40-Rezeptor wahrnimmt. Das Genom des EBV ist in dem Maxi-EBV-System einer genetischen Manipulation zugänglich. Zuerst habe ich verschiedene Mutanten des LMP1 Gens im Kontext des EBVGenoms etabliert und auf ihren Phänotyp untersucht. …
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Anbindung und Aufnahme von Hitzeschockprotein-Antigenkomplexen durch Antigenpräsentierende Zellen
… CD91 die Zelloberflächenrezeptoren LOX 1 und CD40 beschrieben. Unter Verwendung für CD40 und LOX 1 spezifischer Liganden konnte in Kompetitionsexperimenten an Raw264.7 Zellen weder eine Inhibierung der N70 noch eine Inhibierung der C70 Anbindung festgestellt werden. Zusammenfassend können …
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Liposome-anchored local delivery of immunomodulatory agents for tumor therapy
… antibodies against the co-stimulatory receptors CD40 and CD137, Toll-Like Receptor (TLR) ligands such as CpG oligonucleotides, and immunostimulatory cytokines such as IL-2 have all previously demonstrated potent, synergistic anti-tumor effects. However, the clinical use of such therapies is …
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Prognostic Markers and Mechanisms of Chemotherapy Resistance in Diffuse Large B-cell Lymphoma
… whether immunohistochemical expression of CD40, previously associated with a favourable prognosis in DLBCL, had any prognostic impact after the addition of rituximab to anthracycline-based chemotherapy. Results showed better prognosis in CD40-positive patients receiving this combined …
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EGF module-containing mucin-like hormone receptor 2 and its role in human immune privilege
… flow cytometric analysis for expression of CD14, CD40, PDL1, ILT3, and EMR2. Later, T regulatory cells were generated by incubating tolerogenic APCs with autologous huPBMC for five to seven days. Post culture, the T cells were stained and characterized for expression of CD4, CD25, and FoxP3. …
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Histopathology of livers and native organs of recipients following genetically-engineered pig-to-baboon liver xenotransplantation
… costimulation blockade of both the CD28/B7 and CD40/CD154 pathways. Results: In project 1, after GE pig liver transplantation, hyperacute rejection did not occur. Survival was limited to 4 7 days due to repeated spontaneous bleeding as a result of profound thrombocytopenia which necessitated …
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Studies of the Mechanisms of Reverse Signaling by CD40L
<p>CD40 ligand (CD40L) is a transmembrane protein expressed on activated CD4 T cells, traditionally known for its role in forward signaling by engaging CD40 on antigen- presenting cells to promote immune activation. While this pathway is well characterized, there is evidence that CD40L also …
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Effect of Medicinal Herbal, Panax Notoginseng, on the Fate and Function of Professional Antigen Presenting Cells
… as the expression of accessory molecules MHC II, CD40 and CD86, were decreased dependent on notoginseng exposure time-points relative to LPS stimulation. LPS induced IL-1â, IL-6 and IL-12 production was also decreased with concurrent notoginseng treatment for 24 hours. Notoginseng decreased TNF-á …
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Effect of Medicinal Herbal, Panax Notoginseng, on the Fate and Function of Professional Antigen Presenting Cells
… as the expression of accessory molecules MHC II, CD40 and CD86, were decreased dependent on notoginseng exposure time-points relative to LPS stimulation. LPS induced IL-1â, IL-6 and IL-12 production was also decreased with concurrent notoginseng treatment for 24 hours. Notoginseng decreased TNF-á …
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Multiple sclerosis associated SNPs influencing B cell expression of co-stimulatory receptors and T cell responses
… influence the expression of CD86 and CD40 in freshly collected (ex-vivo) B cells. In my research, I sought to extend this work by investigating the impact of these variants in the context of activation in an effort to refine understanding of the molecular mechanisms underlying the …
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