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Showing 1 to 2 of 2 for “"CD4-independence"”.
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Virus tropism and neutralization response in SIV infection
… virus (HIV). Both SIV and HIV normally use the CD4 receptor and an additional coreceptor for cell entry. The most common coreceptors used by HIV are CCR5 and CXCR4. SIV use CCR5 and rarely CXCR4 but may use other coreceptors as alternatives. We have studied virus tropism and evolution of the …
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Dissociating Siv Env and Cd4: Consequenes for Virus and Host
CD4 tropism is conserved among all primate lentiviruses and likely contributes to viral pathogenesis by targeting cells that are critical for the adaptive anti-viral immune responses. Although CD4-independent variants of HIV and SIV have been described that can utilize coreceptors CCR5 or CXCR4 in …