Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"CD4 lymphocytes"”.
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Investigation of the role of antagonism of the Interleukin-7 Receptor in the treatment of Multiple Sclerosis in Humans and In Vitro differences between genetically stratified subjects based on Interleukin-7 Receptor Genotype
… is an autoimmune disease mediated by activated lymphocytes entering the central nervous system. Treatments with the greatest efficacy either prevent the entry of activated lymphocytes, or deplete the lymphocyte population, before allowing lymphocyte reconstitution. IL-7Rα was identified by …
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The Detection and Role of Human Endogenous Retrovirus K (HML-2) In Rheumatoid Arthritis
… in RA patients compared to disease controls with CD4+ lymphocytes harbouring the highest activity. The real-time assay was also used to determine whether factors within the synovium could modulate HERVs, resulting in their upregulation. Exogenous viral protein expression and pro-inflammatory …
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Oral lesions in hiv/aids patients before and after haart treatment
… of viral replications followed by an increase in CD4 lymphocytes, a partial recovery of T-cell specific immune responses and decrease susceptibility to opportunistic pathogens. Aim: The aim of the present study was to determine the prevalence of oral lesions in patients before and after undergoing …
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Ehrlichiosis: Understanding immune mechanisms that lead to the development of fatal disease
… toxic shock-like syndrome marked by apoptosis of CD4+ T cells, a weak CD4 Th1 response, and overproduction of TNF-alpha and IL-10. C57BL/6 mice were inoculated intradermally or intraperitoneally with IOE, models that closely reproduce the pathology and immunity associated with tick-transmitted …
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An investigation of novel therapeutic strategies for the treatment of multiple sclerosis and autoimmunity
… research at GSK, that there is a population of CD4+ lymphocytes with apparent constitutive pSTAT1 expression independent of any stimulus and refractory to JAK-1 inhibition. This pSTAT1hi population had been found to be enriched in patients with systemic lupus erythematosus. The starting …
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The role of Nbeal2 in the homeostasis and retention of granules in haematopoietic cells
… of GPS platelets, neutrophils, monocytes, and CD4+ lymphocytes, compared to healthy blood donors, as well as a pro-inflammatory signature in GPS plasma that may be mediated by changes in the liver. Loss of Nbeal2 function in GPS patients also affected the granularity and presence of …
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Genetic and functional studies in inherited platelet disorders
… GPS, but also in neutrophils, monocytes, and CD4-lymphocytes. Proteomic analysis of plasma by mass spectrometry (MS) identified increased levels of proteins associated with inflammation and the immune response in patients with GPS. Additionally, proximity extension assay analysis identified …
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Investigating the molecular pathogenesis of tuberculosis-associated immune reconstitution inflammatory syndrome
… the partial reconstitution of Mtb-specific CD4 T cell responses within 3 months of initiating ART while on effective antituberculosis therapy. The phenotype and transcription factors of antigen-specific interferon-gamma producing (IFN+) CD4+ T cells and their potential involvement in the …