Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"CD4 T lymphocytes"”.
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Biological effects of trogocytosis on CD4+ T lymphocytes
<p>Antigen recognition by CD4+ T cells leads to large-scale spatial and temporal molecular redistributions, forming the immunological synapse. We have previously shown that upon dissociation, T cells capture large membrane fragments from antigen-presenting cells directly from the immunological …
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Biological effects of trogocytosis on CD4+ T lymphocytes
<p>Antigen recognition by CD4+ T cells leads to large-scale spatial and temporal molecular redistributions, forming the immunological synapse. We have previously shown that upon dissociation, T cells capture large membrane fragments from antigen-presenting cells directly from the immunological …
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Effector CD4⁺ T lymphocytes in the prodrome of polyarthritis
… polyarthritis, the activation and phenotype of CD4⁺ T cells during the prodrome of adjuvant-induced arthritis (AA) has been investigated in rats. Research in the Arthritis Research Laboratory has demonstrated previously that activated CD4⁺ T cells in the thoracic duct (TD) lymph of rats during …
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Characterization of viral- and fungal-reactive CD4+ T cells in healthy and diseased
CD4+ T lymphocytes are central regulators of adaptive immunity, coordinating protective immune responses while maintaining tolerance to harmless antigens. Their antigen specificity, diversity and functional properties are poorly characterized. This thesis is a cumulative work of three manuscripts …
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THE EFFECT OF CONFINEMENT ON T-LYMPHOCYTE UPSTREAM MIGRATION UNDER SHEAR FLOW
… One step is migration on the endothelium. CD4+ T-lymphocytes migrate upstream on intracellular adhesion molecule-1 (ICAM-1). In this thesis, we explore the potential of this upstream migration to direct T cells confined within microcontact printed and microfluidic devices. In the first aim, …
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APOBEC3 Transcriptional Regulation and HIV-1 Restriction in T Lymphocytes
… therapies. HIV-1 primarily infects CD4+ T lymphocytes, and to a lesser degree, macrophages, monocytes and dendritic cells. In the absence of therapeutic intervention, HIV-1 infection results in the gradual depletion of CD4+ T cells, leading to a severely compromised immune response …
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The role of donor CD4 T lymphocyte chimerism in lung transplant recipients
… was dependent upon provision of help from donor CD4 T cells that were passengers within the graft. However, the fate of the donor passenger CD4 T cells in clinical organ transplantation is unclear. To assess whether a similar mechanism may occur in human transplant recipients, I have studied the …
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HIV-1 INFECTION OF NEURAL STEM CELLS RESULTS IN COGNITIVE DEFICITS THROUGH ADULT NEUROGENIC MODULATION
… mechanisms underlying HAND. HIV-1 infects CD4+ T-lymphocytes and monocytes in the peripheral circulatory system. After these infected cells cross the BBB into the CNS, they release toxic viral proteins and viral particles onto microglia and astrocytes. These glial cells become activated, …
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Patrones radiológicos pulmonares y su relación con linfocitos TCD4+ en pacientes con infección por VIH. Fundación Cardioinfantil, 2013 - 2017
… pulmonares y niveles séricos de linfocitos T CD4+ en pacientes adultos, con infección por VIH, en seguimiento en la Fundación Cardioinfantil de 2013-2017. Materiales y métodos: estudio observacional descriptivo de una cohorte. Resultados: se evaluaron 108 pacientes con infección por VIH, en …