Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 208 for “"CD4 T cell"”.
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Intestinal CD4+T Cell Responses to Food
… critical homeostasis. Oral tolerance requires CD4<sup>+</sup> T cells including specifically regulatory T cells (Tregs), however the role of intestinal CD4<sup>+</sup> T cells and the T cell repertoire in a physiological response to food protein remains largely unexplored. To characterize …
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The CD4⁺ T Cell Response to Human Cytomegalovirus
… such as after solid organ or haematopoietic stem cell transplantation, the virus is then able to multiply rapidly and infect numerous organ systems. Consequently, HCMV is one of the most frequently-occurring viral infections in such patients. Most of the previous studies on HCMV infections in …
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Decoding CD4+ T cell activation by multi-modal phenotyping
The activation of CD4+ T cells is strongly implicated in the biology of immune-mediated diseases, yet the molecular and functional mechanisms governing this process remain incompletely understood. With the explosion of profiling and functional genomic methods in the last decade, it is now feasible …
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Cd4 T Cell Activation And Ox40 Agonist Immunotherapy In Tuberculosis
… (Mtb) infection millions of effector T cells traffic to the lungs, but relatively few find antigen and become activated. We used an antigen receptor reporter mouse (Nur77-GFP) infected with Mtb to distinguish recently activated CD4 T cells from others in the lungs. Recently activated …
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Spatial Dynamics and the Mechanoresponse in CD4+ T Cell Activation
The activation of naïve CD4+ T cells by antigen presenting cells is a critical step in the response of the immune system to foreign pathogens and in its acclimation to host tissues. Activation of naïve T cells proceeds through TCR engagement and is further augmented by CD28 costimulation: ensuring …
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CD4+ T cell response against food antigens in intestinal disease
… immune system, in particular antigen-specific CD4+ T cells, are thought to play a key role in this process, but the exact mechanisms leading to the development and maintenance, as well as the failure, of oral tolerance are still not fully understood. T cells that recognize one particular …
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The role of lactate in CD4+ T cell differentiation and function
… has been already studied in the context of CD4+ T cells differentiation, nothing was known about the less abundant D- enantiomeric form until now. By supplementing in vitro cultures of Th1 and Th2 cells with exogenous D- or L-lactate, we describe for the first time D-lactate’s enormous …
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Control of chromatin accessibility during CD4+ T cell development and activation
T cells coordinate immune functions by differentiating into highly specialised cellular lineages that either promote or suppress immune reactions. Whereas effector T (Teff) cells drive immune activation and promote clearance of infections and cancer, regulatory T (Treg) cells suppress their …
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CD4 T cell allorecognition pathways in acute and chronic allograft rejection
… this work are as follows: 1) If able to evade NK cell killing, passenger donor CD4 T cells can make cognate, direct-pathway, interactions with recipient B cells. This interaction results in augmentation of all arms of the alloimmune response and acceleration of allograft rejection. 2) …
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Upstream conserved sequence element that regulates TIM-3 induction in CD4+ T cell
The T cell immunoglobulin domain and mucin domain-3 (TIM-3) was discovered in Th1 and has been known as a T cell regulatory molecule. TIM-3 expression is induced by T cell activation through mechanism not yet well-investigated. In the study, I wanted to find DNA region involved in regulation of …
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Transdisciplinary Strategies to Study the Mechanisms of CD4+ T cell Differentiation and Heterogeneity
CD4+ T cells mediate and orchestrate a tremendous panoply of lymphoid cell subsets in the human immune system. CD4+ T cells are able to differentiate into either effector pro-inflammatory or regulatory anti-inflammatory subsets depending on the cytokine milieu in their environment. This complex …
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Inflammasome-Independent Interleukin-1 Beta Drives CD4 T Cell Effector Function and Autoimmune Inflammation
… arms of the immune system. Innate immune cells sense the infectious threat to the host and convert it into meaningful information that is relayed to T and B cells. This relaying of information is the fundamental principle that forms the basis of all protective immune responses and is …
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Enrichment and Transcriptome Analysis of CD4+ T Cell Clones Harboring Intact HIV-1 Proviruses
… that infects and destroys predominantly CD4+ T cells. Since CD4+ T cells are crucial for the innate and adaptive immune system, their progressive loss in the course of HIV-1 infection leads to the Acquired Immune Deficiency Syndrome (AIDS). Antiretroviral therapy can suppress the virus in …
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Novel Tools for Investigating Microglia Cellular Turnover Kinetics and Microglia-CD4 T Cell Interaction
… population size, contributing to 5-12% of cellular tissue in the mouse brain, depending on brain region. Following injury and under inflammatory conditions microglia undergo microgliosis, a rapid expansion in number and change in activation state. Microgliosis has been observed in multiple …
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Studies on CD4+ T cell subsets in Mycobacterium tuberculosis immunity during HIV co-infection
… within the first year of infection, even when CD4+ T cell counts are still high. Previous studies have demonstrated that M.tb-specific CD4+ T cell responses are depleted early after HIV infection, within 3-12 months. This early defect in M.tb-specific CD4+ T cells may explain the elevated risk …
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HETEROGENEITY OF LATENCY ESTABLISHMENT IN DIFFERENT HUMAN CD4+ T CELL SUBSETS STIMULATED WITH INTERLEUKIN-15
… and persists for the lifetime of the infected cell. Even in the presence of an efficacious Highly Active Anti-Retroviral Therapy (HAART) treatment, a pool of latently infected cells persists and reactivates to produce viral particles if antiretroviral therapies are stopped or discontinued. This …
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Posttranscriptional gene regulation of CD4+ T cell cytokine expression by the RNA binding protein HuR
… such as HuR fine tunes gene expression in T cells leading to powerful effects on immune responses. HuR can stabilize target mRNAs and/or promote translation by interacting with their 3-UTR AUrich elements. We discovered that the interaction of HuR with the Il2ra (CD25) mRNA transcript is …
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The dependence of CD4 T cell development and activation on the kinetics of the TCR:pMHC interaction
<p>The T cell is a critical player in the adaptive immune response. T cells function by stimulating antibody production by B cells, secreting cytokines to attract other immune cells, regulating the response of other T cells, and directly killing infected or damaged targets. The role of the adaptive …
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CD4+ T cell recognition of Epstein-Barr virus nuclear antigen (EBNA) - 1 in the Chinese population
… expression of EBV antigens in NPC tumour cells and the presence of EBV-specific T cells at the tumour site. More importantly, studies in other EBV-associated diseases strongly indicated that CD8+ T cell based immunotherapy targeting EBV antigens could control EBV infection and also tumour …
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Investigation of CD4+ T cell heterogeneity and function in a genetic mouse model of lung adenocarcinoma
… of immunosuppressive mechanisms is needed. CD4+ T cells, which are phenotypically diverse, orchestrate many diverse components of immune responses, and can contribute to tumor growth through a variety of mechanisms. Regulatory T cells (Tregs) in particular are an immunosuppressive …
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