Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 44 for “"CD4+CD25+"”.
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Role of CD4+CD25+ Regulatory T Lymphocytes in Experimental Toxoplasmosis
… the present study was to investigate the role of CD4+CD25+ T regulatory lymphocytes in mice infected with <i>Toxoplasma gondii</i>. T regulatory (Treg) cells have been shown to play an important role in our immune system in controlling the activity of other T lymphocytes. These cells are …
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Transcriptional and extracellular programs define CD4+ CD25+ regulatory T cells
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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단순포진바이러스로 유도된 베체트병 마우스모델에서 CD4+CD25+ 조절 T 세포의 역할
… cells isolation and culture G. Co-culture of CD4+T cells with DCs H. Isolation of CD4+CD25+T cells I.Adoptive transfer of CD4+CD25+T and CD4+CD25-T cells to BD-like mice J. ELISA K. Reverse transcription PCR (RT-PCR) L. Statistical analysis Ⅲ. RESULTS A. CD4+CD25+ Treg cells in BD-like mice …
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Phänotypische und funktionelle Charakterisierung von CD4+CD25+ "regulatorischen" T-Zellen aus dem Nabelschnurblut
… zu untersuchen. <br>Ziel: Isolierung von CD4+CD25+ T-Zellen aus dem Nabelschnurblut, Proliferation und Zytokin-produktion dieser Zellen im Vergleich zu CBMC. <br>Methoden: Von 42 gesunden Neugeborenen wurde Nabelschnurblut entnommen. CBMC wurden mittels Dichtezentrifugation isoliert. …
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Regulation of Murine Mast Cell Homeostasis by TGF-β1 and CD4+CD25+C Regulatory T Cells
… β1 has many cellular sources, one of which is CD4+CD25 regulatory T cells (Tregs). We wanted to determine the effects of Transforming Growth Factor (TGF) βl on mast cell development. We find that TGFβl decreased FcεRI, c-Kit, T1/ST2 and FcεR expression, and inhibited granule formation in …
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Mechanisms Mediating Asthma Tolerance Induced By Regulatory Dendritic Cells Through CD4+CD25+Foxp3+ T Regulatory Cells
… responses. We explored the important role of CD4+CD25+Foxp3+ regulatory T cells (Treg) in the induction of tolerance by DC10 in three levels. We first used the siRNA approach to silence IL-10 gene expression in murine DC10 and we generated DC10 from CD80/86 or H-2Iab gene-KO mice. When used to …
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T regulatory Cell Suppression of CD8+ Lymphocyte Responses During FIV Infection.
… for human AIDS, we reported previously that CD4+CD25+ Treg cells in both the acute phase and long-term, asymptomatic phase of infection are constitutively activated and suppress CD4+CD25- T cell immune responses. Building upon these observations, we tested the hypothesis that CD4+CD25+ Treg …
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T-Regulatory Cells and FLT3-Ligand in the Therapy of Cockroach Antigen-induced Asthma
… immune T cell subset T-regulatory cells (Tregs) (CD4+CD25+). Tregs are divided into two categories: “naturally occurring” CD4+CD25+ T regulatory cells (NTregs), that constitutively express Foxp3 and CD25, and “inducible” CD4+CD25- T regulatory cells (iTregs), which up-regulate CD25 and Foxp3 after …
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Phenotypic and Functional Analysis of Regulatory T Cells during Heligmosomoides polygyrus infection
… Classically, in mice, Tregs are defined as CD4+CD25+ T cells. We have demonstrated that, unlike in BALB/c mice, in C57BL/6 animals, infection with the gastrointestinal nematode Heligmosomoides polygyrus does not result in increased CD4+CD25+-mediated suppressive activity. Using two different …
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The role of IL-27 and IL-35 in inflammatory diseases
… inhibited the development of Th17 from naïve CD4+, CD4+CD25- and CD4+CD25+ T cells, but had little or no effect on differentiated Th17 cells. Together, these results demonstrated that IL-27 had both pro-inflammatory and anti-inflammatory effects on chronic articular inflammation, mainly …
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Peripheral Generation of Regulatory T Cells in Health and Disease
CD4+CD25+FOXP3+ regulatory T cells (Tregs) form an important arm of the immune system responsible for suppressing untoward immune responses. They play a role in autoimmunity, allergy, asthma, transplantation, tumors and infectious diseases. Tregs are increased in the peripheral blood of chronic …
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Proporción de subpoblaciones linfoides T y B con fenotipo regulador, inflamatorio y autorreactivo en tejido gingival de pacientes con periodontitis
… procesada para tinción con los marcadores CD3, CD4, CD25, CD161, RIL23, FOXP3, CD19, CD5, CD1d por inmunohistoquímica y la segunda parte se analizo por citometría de flujo caracterizando, las población según esta distribución, T reguladoras: CD3, CD4, CD25, CD127, CD45 y FoxP3. TH17: CD3, CD4, …
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The effects of topical calcipotriol treatment on immune responses to vaccination
… immunization results in the induction of CD4⁺CD25⁺ Tregs capable of inhibiting the elicitation of a contact hypersensitivity response. We also demonstrate that topical calcipotriol has significant effects on the immune response to subcutaneously injected vaccines, and compare it with …
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EGF module-containing mucin-like hormone receptor 2 and its role in human immune privilege
… flow cytometric analysis for expression of CD14, CD40, PDL1, ILT3, and EMR2. Later, T regulatory cells were generated by incubating tolerogenic APCs with autologous huPBMC for five to seven days. Post culture, the T cells were stained and characterized for expression of CD4, CD25, and FoxP3. …
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Altered Expression of Costimulatory Molecules in Behcet's Disease According to Clinical Activity
… BD group, the surface expression of CTLA-4 on CD4+ T cells was decreased in the stimulated state compared with HC group. In contrast, the surface expression of PD-1 on CD4+ T cells and CTLA-4 on CD8+ T cells did not show significant differences among each group. There were no differences of …
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Porcine circovirus associated disease: Modulation of the host immune response to PCV2 and PRRSV by regulatory T cells
… DCs infected with PCV2 significantly increased CD4+CD25+FoxP3+ Tregs (p<0.05) and DCs co-infected with PRRSV and PCV2 induced significantly higher numbers of Tregs than with PCV2 alone (p<0.05). This Treg induction was found to be dependent on TGF-β and not IL-10. Further investigation of the in …
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Immune cell alterations in mouse models of prostate cancer
… stimulation. Furthermore, we demonstrated that CD4+CD25+ regulatory T cells were responsible, at least in part, for this alteration. Anti-CD25 antibody treatment reduced, but did not prevent, tumour growth in either a transplanted prostate tumour model or a spontaneously developing prostate …
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Defining the biological role of FOXP3 in human CD4+ T cells
… focused on defining the characteristics of the CD4⁺CD25⁺ Treg subset, as these cells can mediate dominant, long-lasting and transferable tolerance in many experimental models. The aim of this research was to characterize the biological role of a protein known as forkhead box P3 (FOXP3) that was …
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Role of IL-17A and Acaid in the Maintenance of Corneal Immune Privilege
… of a newly identified T cell subset, the Th17 CD4+ T cell lineage and its production of the cytokine, IL-17A in modulating corneal immune privilege and the outcome of keratoplasty. Previously, the Th17 T cell subset and its pro-inflammatory cytokine, IL-17A had been associated with the …
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