Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 1115 for “"CD4"”.
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Intestinal CD4+T Cell Responses to Food
… critical homeostasis. Oral tolerance requires CD4<sup>+</sup> T cells including specifically regulatory T cells (Tregs), however the role of intestinal CD4<sup>+</sup> T cells and the T cell repertoire in a physiological response to food protein remains largely unexplored. To characterize …
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Targeting the CD4 Binding Site of HIV
… locus in mice. 3BNC60 is a bNAb that targets the CD4 binding site (CD4bs) of HIV-1 and belongs to the IgHV1-2 class of broadly neutralizing CD4bs antibodies. In the first part of my thesis I will describe the evolution of the HIV-1 antibody response in GLVH and MuVH mice upon immunization. We …
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Developmental Regulation of the Murine CD4 Gene
<p>CD4 is a membrane bound glycoprotein that plays an important role in T cell development and activation. An extensive analysis of the CD4 locus identified potential transcriptional control elements located 5' of the promoter and within the first intron. Since the molecular mechanism for the …
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Biological effects of trogocytosis on CD4+ T lymphocytes
<p>Antigen recognition by CD4+ T cells leads to large-scale spatial and temporal molecular redistributions, forming the immunological synapse. We have previously shown that upon dissociation, T cells capture large membrane fragments from antigen-presenting cells directly from the immunological …
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How CD4+ T Cells Recognize Allostimulatory Peptide-MHC
… whether tolerance is achieved or not, are CD4+ T cells that can recognize peptides presented on allogeneic (non-self) Major Histocompatibility Complex (MHC) molecules in addition to their conventional ligands, peptides presented on self MHC. It is an enigma as to how these alloreactive T …
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On Modeling HIV Infection Of Cd4+ T Cells
… an early model for the interaction of HIV with CD4+ T cells in vivo and define possible parameters and effects of said parameters on the model. We then examine a newer, more simplified model for the interaction of HIV with CD4+ T cells that also considers four populations: uninfected T cells, …
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Biological effects of trogocytosis on CD4+ T lymphocytes
<p>Antigen recognition by CD4+ T cells leads to large-scale spatial and temporal molecular redistributions, forming the immunological synapse. We have previously shown that upon dissociation, T cells capture large membrane fragments from antigen-presenting cells directly from the immunological …
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Immunomodulatory effect of pneumolysin upon CD4 T cells
… the heart of the adaptive immune response; the CD4 T cell. I generated purified pneumolysin and a purified pneumolysin mutant called F433 to allow me to examine this potential effect. I found that pneumolysin inhibits in vitro antigen specific murine CD4 T cell proliferation and cytokine …
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The CD4⁺ T Cell Response to Human Cytomegalovirus
… of peripheral blood mononuclear cells (PBMCs), CD4+ cells, CD8+ T cells, and natural killer (NK) cells to HCMV infection of autologous fibroblasts in healthy HCMV-seropositive and HCMV-seronegative adults, and showed that there were inherent differences in the ability to control HCMV …
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Dynamics of Naive and Memory CD4 T-cells in Chronically Infected HIV Patients Post-Injection of Down-Modulated CCR5 Memory CD4-Cells
… individuals worldwide. This retrovirus targets CD4 T-cell populations, the main driver of the immune system by using the chemokine co-receptor 5 (CCR5). Despite the success of the highly active antiretroviral therapy in reconstituting the immune system, HIV infected individuals still suffer from …
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Caracterización de los linfocitos T Cd4 específicos de Rotavirus
En la infección por rotavirus los linfocitos T CD4 son importantes porque estimulan a los LB a que produzcan anticuerpos IgA protectores. El objetivo principal del estudio fue caracterizar los linfocitos T CD4 humanos específicos de rotavirus. Por métodos bioinformáticos se seleccionaron 39 …
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CD4+ T cells in the pathogenesis of visceral leishmaniasis
… infection is dependent on Th1 (IFNγ producing) CD4+ T cells, which activate macrophages to produce nitric oxide and kill the intracellular parasites. Despite there being an expansion of CD4+ T cells and an increase in pro-inflammatory molecules in the spleen, humans with active visceral …
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Effector CD4⁺ T lymphocytes in the prodrome of polyarthritis
… polyarthritis, the activation and phenotype of CD4⁺ T cells during the prodrome of adjuvant-induced arthritis (AA) has been investigated in rats. Research in the Arthritis Research Laboratory has demonstrated previously that activated CD4⁺ T cells in the thoracic duct (TD) lymph of rats during …
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Characterising the gene regulatory landscape of CD4+ T cells
… overlap with active regulatory elements in CD4+ T cells, and particularly in regulatory T cells (Tregs). CD4+ T cells are the orchestrators of the adaptive immune response and their dysfunction has been associated with immune-mediated disorders through uncontrolled activation and resistance …
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Decoding CD4+ T cell activation by multi-modal phenotyping
The activation of CD4+ T cells is strongly implicated in the biology of immune-mediated diseases, yet the molecular and functional mechanisms governing this process remain incompletely understood. With the explosion of profiling and functional genomic methods in the last decade, it is now feasible …
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Regulatory CD4+FOXP3+ T cells in Helicobacter pylori-induced disease
… by immunohistochemistry that FOXP3-expressing CD4+ T-cell numbers increase in areas of duodenal gastric metaplasia compared to normal duodenal mucosa and are associated to CD4+ T-cell aggregates in the duodenum of Helicobacter pylori-infected duodenal ulcer patients. The increase of …
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CD4+ T cell response against food antigens in intestinal disease
… immune system, in particular antigen-specific CD4+ T cells, are thought to play a key role in this process, but the exact mechanisms leading to the development and maintenance, as well as the failure, of oral tolerance are still not fully understood. T cells that recognize one particular …
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