Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 53 for “"CD36"”.
-
Secreted Factors from CD36+ Fibroblasts Induce Tumor Suppression in Subtypes of Breast Cancer
… mammary gland, fibroblasts (FBs) overexpress CD36; the downregulation of CD36 is one of the hallmarks of cancer-associated FBs. Therefore, in this project, we hypothesized that signaling from CD36+ FBs could cause growth suppression in a subset of breast cancer cell lines. We then designed a …
-
Mechanisms of Western-Diet Induced Endothelial Stiffening: Endothelial CD36 and Long-Chain Fatty Acids
… mediated by endothelial scavenger lipid receptor CD36. Through the use of an inducible, endothelial-specific CD36 knockdown mouse model, we discovered that loss of endothelial CD36 prevents endothelial stiffening and minimizes barrier leakage. We discovered that WD-induced endothelial stiffening …
-
Studies of CD36 interacting with fatty acids, oxidized low-density lipoprotein, and the cellular plasma membrane
The glycoprotein CD36 is expressed in the plasma membrane (PM) of many cell types that surround or contact arteries, including macrophages, myocytes, and endothelial cells. CD36 binds oxidized low density lipoprotein (oxLDL), which promotes atherosclerosis, and fatty acids (FA), which promotes …
-
Effekte des oxidativen Stresses auf die Expression der Scavenger-Rezeptoren CD36 und SR-BI und des Transkriptionsfaktors PPARγ in Makrophagen
… Expression der atherogenen Scavenger-Rezeptoren CD36, SR-BI, des Transkriptionsfaktors PPARγ und pro-inflammatorischer Zytokine zu untersuchen. Die durchgeführten Untersuchungen beruhen auf der Annahme, dass modifizierte LDL durch Induktion der genannten Scavenger-Rezeptoren und nachfolgende …
-
Senescence Associated Secretory Phenotype Regulation in Lung Aging and Malignancy Progression
… and discovered a multi-ligand scavenger receptor CD36 is rapidly upregulated in multiple cell types in response to replicative, oncogenic and chemical senescent stimuli. Moreover, ectopic CD36 expression in dividing mammalian cells is sufficient to initiate the production of a large subset of …
-
Analysis of the function and subcellular localization of FAT/CD36 in hepatocytes and transfected cell lines of hepatic and non-hepatic origin.
The class B scavenger receptor CD36, or fatty acid translocase (FAT), is an 88 kDa plasma membrane glycoprotein that is the founding member of the class B scavenger receptor family. It has a number of natural ligands and has different functions at various locations in the body. It contributes to …
-
Characterisation of the cell-surface localised palmitoyl acyl transferase, DHHC5
… of two novel DHHC5 substrates; FAT/CD36 and Gai2. Palmitoylation of GFP-tagged FAT/CD36 and Gai2 was reduced in DHHC5 KO cells compared to HEK293 cells. This was rescued by overexpression of DHHC5 but not DHHC17 in DHHC5 KO cells, confirming these as DHHC5 …
-
Lysophosphatidylcholine acyltransferase-2 (LPCAT-2) & protein S-acylation in macrophage innate immunity
… the acylation of the scavenger receptors CD36 and Lysosome membrane protein II. Further investigation established that CD36 positively regulates LPS induced cytokine responses in macrophages and that S-acylation of CD36 regulates both lipid raft association and surface expression. This …
-
Monocyte Modulation of Disease Pathogenesis and Progression in Localized Aggressive Periodontitis
… and function of the scavenger receptor CD36. LAgP monocytes have exhibited decreased activity of the PAF-acetylhydrolase (PAFAH), the catalytic enzyme that breaks down PAF. Since PAF levels are regulated by synthesis and degradation, we hypothesized that synthesis by myeloid cells, …
-
Mechanisms of Post-hemorrhagic Hydrocephalus after Germinal Matrix Hemorrhage
… phagocytosis of erythrocytes via CD36 scavenger receptor, augmenting clot resolution and improving outcomes after adult cerebral hemorrhage. Additionally, lysed erythrocytes and metabolized hemoglobin release iron, which is associated with brain injury after adult cerebral …
-
Molecular Mediators of Macrophage Foam Cell Formation and Atherosclerosis and their Pharmacological Modification
… with reduction in the glycosylated form of the CD36 cholesterol uptake receptor, and its reduced expression on the cell surface membrane. Colchicine also increases the efflux capacity of cholesterol to high-density lipoproteins (HDL), accompanied by a selective increase in the surface expression …
-
Identification of Epo-independent red cell progenitors : the E-cad+ progenitors
… Epo-unabhängigen Population von Vorläuferzellen (CD36+ Vorläuferzellen), die ebenfalls erythroide Eigenschaften aufweisen. Ziel dieser Arbeit war die Isolierung und Charakterisierung von Epo-unabhängigen Vorläuferzellen, die eine frühe erythroide und möglichst homogene Vorläuferzellpopulation …
-
Avaliação plasmática, histológica e imunohistoquímica de biomarcadores da aterosclerose humana precoce e crônica
… risk markers and receptors for LDL-r, CD36 and CD68 in fragments and internal thoracic aorta was determined. Results. Lipid profile data between groups said as chronic (> 56 years) and said as precocious (<56 years) were different (p <0.05). The indices in the group <56 years were above …
-
The influence of oxidised low density lipoproteins on platelet activation
… platelet activation is the scavenger receptor CD36. The expression of this scavenger receptor was found to increase upon stimulation with a range of platelet agonists. Furthermore, platelet shape change was discovered to be downstream of CD36. The findings of this report therefore elucidate two …
-
Effects of Omega-3s and Vitamin E Prophylactic Diets and the Implications of Lipid Transport in Spinal Cord Injury
… cluster of differentiation 36 (FAT/CD36) is a B class scavenger receptor, which has been implicated in the uptake and signaling of hydrophobic molecules, including ω3PUFAs and Vitamin E. Female adult Sprague-Dawley rats were received tail injections with ω3PUFAs (i.e. DHA) or were …
-
Ex Vivo Induction of Human Regulatory T Cells
… subset with increased cell surface expression of CD36 and the TGF-beta related latency associated peptide, LAP. We termed this unique cellular subset CD14+CD36HI monocytes, and further demonstrated their expression of the LAP-TGF-beta binding transmembrane molecule GARP, functioning to tether …
-
Molecular Response of Retinal Pigment Epithelial Cells to Oxidized Lipoproteins: Global and Targeted Studies
… <p>We studied the role of scavenger receptors CD36 and CD5L/AIM in ARPE-19 cells when induced with oxLDL. We compared three different multidimensional proteome fractionation platforms: polymeric reversed-phase liquid chromatography at high pH (PLRP), sodium dodecyl sulfate-polyacrylamide gel …
-
Crosstalk between CX3CL1 and the Cytoskeleton during Vascular Inflammation
… and clustering of the scavenger receptor CD36. Consequently, CD36 more readily engages and internalizes cholesterol-rich, oxidized low-density lipoproteins, leading to the accumulation of cholesterol esters within macrophages, and thus, the acceleration of foam cell formation. These …
-
The role of lipid laden macrophages in airways disease
… dietary lipid uptake, independently of actin or CD36. Lipid accumulation also results from the phagocytic clearance of apoptotic epithelial cells, which may account for the lack of LLAMI specificity for GOR. Our attempts to generate and distinguish polarised macrophages were unsuccessful and as a …
Page 1 of 3