Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 14 of 14 for “"CD30"”.
-
CD30: A Novel Receptor to Induce Apoptosis in Human Blood Eosinophils
… regulating eosinophil apoptosis remains limited. CD30 molecule has been associated with T cell negative selection and in T cell receptor-mediated apoptosis. In this thesis dissertation I examined the expression and role of CD30 in apoptosis of human blood eosinophils. Percentage of apoptotic …
-
Zur Rolle des CD30 Liganden bei der Induktion einer spezifischen Immunantwort gegen Melanomzellen
… zur Aktivierung von T-Zellen liefern. CD30L wurde im Vergleich zu B7-1 als kostimulatorisches Molekül evaluiert. CD30L und B7-1 konnten auf Melanomzellen stabil zur Expression gebracht werden. Diese Melanomzellen wurden mit T-Zellen inkubiert und die induzierte Expression von …
-
Modelling RANBP2-ALK-rearranged Epithelioid Inflammatory Myofibroblastic Sarcoma
… or cytoplasmic with perinuclear accentuation, CD30 expression and early relapse despite crizotinib treatment [1, 2]. This study aimed to generate and utilise models of eIMS to assess molecular-targeted therapeutic combinations to prevent and/or treat ALK inhibitor relapse. Two approaches were …
-
Development of novel RNA- and protein-based cancer therapeutics by either silencing of potential oncogenes or active restoration of a tumor suppressor gene
… lymphoma cells carrying the tumor-associated CD30 receptor. This was achieved by genetically fusing a constitutively active version of DAPK2 to the CD30 ligand, thus decreasing the likelihood of systemic toxicity and providing proof-of-principle that compounds ineffective or unsuitable as …
-
Expression des Transkriptionsfaktors NF-kappaB in Zellen des Hodgkin-Lymphoms und des großzelligen anaplastischen Lymphoms
… Nach Stimulation des Oberflächenrezeptors CD30 mit dem agonistischen monoklonalen Antikörper M44 konnte in der vorliegenden Arbeit keine NF-kappaB-Induktion festgestellt werden. Nach PMA-Ionomycin-Stimulation fiel in LCAL-Zellen die Aktivität des p65/p50-Komplexes nach vier Stunden ab, in …
-
Überexpression von s-Adenosylhomocystein-Hydrolase (SAH) in Zellen der Epstein-Barr Virus-Genom positiven Zell-Linie B95-8
… expression of surface markers CD11a, CD19, CD23, CD30, CD40, CD44, CD54, and CD58 has not been detected. The clarification of reaction mechanisms to activate the lytic cycle is an important step for the development of substances to therapy EBV associated tumors.
-
Cell surface receptor specific delivery of short interfering RNAs via bivalent aptamer-siRNA transcripts or covalent antibody-siRNA conjugates
… siRNA sense strand were conjugated to an anti CD30 specific antibody by the application of two different heterobifunctional linkers (SPDP/SMCC). On average three siRNA molecules could be fused to one antibody. The conjugation chemistry applied did not affect the antibody binding …
-
Generierung von Transposonmutanten des Epstein-Barr-Virus zur Charakterisierung von Genfunktionen für die lytische Virusvermehrung und die virale Latenz
… expression of surface markers (CD11a, CD23, CD30, CD40, CD44, CD54, CD58). Wildtype EBV infected cells and uninfected cells were used as controls. Both mutants expressed a subset of the investigated genes for a short period. An increased surface marker expression could not be detected and the …
-
Signals for B cell activation in antibody response
… IL-6, IL-10, IL-21, costimulatory signals OX40, CD30 deficient mice show that these signals can affect the development of these early IRF4\(^+\) plasmablasts on the GC-T zone interface in the TD antigen response.
-
Development of bispecific filamentous bacteriophages for the generation of a novel automated screening system based on phage display technology
… display of the extracellular domain of the human CD30 receptor fused to the C-terminus of the pVI coat protein was shown to be feasible but reduced the assembly efficiency of the phages. Multivalent display of single chain Fv antibodies fused to pIX coat protein showed a lethal effect on the …
-
Immunocytochemical typing of primary tumors on fine needle aspiration cytologies of the liver and lymph nodes
… applying LCA, CD20, CD79a, CD45Ro, CD15 and CD30. RESULTS: Applying immunocytochemistry as an adjuvant method to cytological smears the following diagnostic accuracy could be reached: 1) 100% for the differentiation of HCC from MC; 2) 90.3% for the identification of primary tumor sites from …
-
Molecular epidemiology of haemoglobin in the population of Libya and the molecular biology of normal and abnormal globin gene expression
… found were ~o IVS-I,I(G ->A) N = 1 and IVS-I,-1 (CD30) (G ->A) N = 1. Also, the associated haplotypes with the most common β-thalassaemia genes had been studied. Haplotypes I and VII were associated with βo CD39, Haplotypes VI and VII with β+IVS-I, 6, Haplotype I with β+IVS- I,110 and haplotype V …
-
Untersuchung zur Rolle von Notch1 in T-Zellentwicklung und Lymphomgenese
… Ein anderes interessantes Kandidatengen ist CD30, ein Transmembran-Rezeptor welcher bei Hodgkin Lymphomen beschrieben wurde. Neben T-ALL wurde auch bei Hodgkin Lymphomen eine wichtige Rolle von Notch1 berichtet. Dabei könnte dessen hohe Expression im Zusammenhang mit der Transformation und …
-
Immunhistochemischer Algorithmus zur Diagnostik maligner Keimzelltumoren des Hodens
Maligne Keimzelltumoren des Hodens sind die häufigsten soliden malignen Tumoren des jungen Mannes und werden in Seminome und Nicht-Seminome unterteilt. Histopathologisch können Nicht-Seminome in embryonale Karzinome, Dottersacktumoren, Chorionkarzinome und Teratome unterschieden werden. Die exakte …