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The mechanobiology of the T-Cell Receptor: Structurally connecting catch bonds with ligand binding and triggering

Cardenas Lizana, Paul AntonioGeorgia Institute of Technology2017

… recognition of antigens and the activation of CD3 signaling domains by the T-Cell Receptor (TCR) are studied. The first part is focused to investigate how the information encoded in the peptide is decoded mechanically by the TCR and what is the structural role of catch bonds. It is proposed …

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