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Applying single-molecule localisation microscopy to achieve virtual optical sectioning and study T-cell activation

Palayret, Matthieu Grégoire SimonUniversity of Cambridge2015

… require the co-stimulatory triggering of the CD28 transmembrane receptor to become fully activated. However, some immobilised anti-CD28 antibodies, referred to as super-agonists (SA), can directly activate T cells without triggering the TCR. In this thesis, single-molecule tracking techniques …

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