Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"CD28 costimulation"”.
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Investigating the role of CD28 costimulation and IL-4/IL-13 responsive myeloid and lymphoid cells during helminth infections in mice
… of this study was to evaluate the importance of CD28 in initiating protective Th2 immunity against both primary and secondary infections with N. brasiliensis. Our findings demonstrate that CD28 is required for initiation of protective Th2 immunity against primary infection with N. brasiliensis. …
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The Characterization of T-Cell Manufacturing For Adoptive T-Cell Therapies
… In addition, I show that expression of CD28 correlates with multiple manufacturing metrics, including final T-cell fold expansion. I propose that the loss of CD28 expression creates a<em> </em>T-cell expansion bottleneck in which certain T-cell clones are heavily favored compared to …
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Spatial Dynamics and the Mechanoresponse in CD4+ T Cell Activation
… TCR engagement and is further augmented by CD28 costimulation: ensuring T cell survival and conferring numerous functional capabilities. The work in this dissertation highlights the spatial and temporal dynamics that regulate the initial coupling of CD28 with TCR signaling and also dissects …
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The Role of Alternative Splicing and Alternative Polyadenylation in Regulating Activated T cell Biology
… of human naive CD4+ T cells stimulated with anti-CD28, anti-CD3, and anti-CD3/CD28 for 8 and 48hrs, to further elucidate the signal-specific regulation of alternative splicing and alternative polyadenylation changes upon stimulation. I show that splicing and polyadenylation changes that occur …
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Characterising the gene regulatory landscape of CD4+ T cells
… receptor (TCR) recognition of an antigen and CD28 co-stimulation. The role of CD28 co-stimulation requirement in the activation of different T cell subsets has been understudied. Here, I assessed the role of immune disease variants in modulating pathways underlying T cell activation and Treg …