Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 23 for “"CD24"”.
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CD21 and CD24 Co-expression: A Translational Model between Mouse and Human
… work shows that the co-expression of CD21 and CD24, determined by 7-color flow cytometry, can be used to demarcate developmental subsets of B cells. A comparison of analogous B cell subsets in mice and humans showed that the B cell subsets distribution differs between the species suggesting …
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Discovery of IKBKE and CD24 siRNAs for the treatment of triple-negative breast cancer
… Breast cancer also expresses high levels of CD24, which is a heavily glycosylated glycosylphosphatidylinositol (GPI)-anchored surface protein and plays an important role in tumor growth, invasion, and metastasis. Moreover, overexpression of CD24 in tumors is associated with resistance to …
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THE STUDY OF CD24 AS A PREDICTIVE INDICATOR IN CISPLATIN TREATMENT RESPONSE OF HEAD AND NECK CANCER
… to platinum-based therapy. In this regard, CD24 expression level appears to be a significant molecular phenotype of cisplatin resistance in laryngeal carcinoma. This study demonstrates that CD24 expression level in HNSCC has a linear relationship with cisplatin resistance, and it affects the …
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Investigation of a pancreatic derived progenitor cell population for use in regenerative medicine
… Thy1.1 negative PDPC population was positive for CD24. The common developmental origin of the liver and pancreas suggests that these organs may share common stem/progenitor cell populations. The in vitro potential of both subpopulations of PDPCs (Thy1.1 positive and Thy1.1 negative) to undergo …
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Molecular, functional and developmental analysis of B cells at discrete stages of development
… Human transitional B cells can be identified as CD24++CD38++CD10+ cells and attempts have been made to segregate them into subsets based on the expression level of CD24 and CD38. Here we have identified 2 subsets of human transitional B cells (CD20+CD27-CD10+) based on the differential expression …
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Vývoj vybraných CD znaků a jejich role ve fylogenezi imunitního systému člověka
… CD markers of human, namely CD19, CD20, CD21, CD24, CD27 and CD38 molecules. In addition, nucleotide and amino acid sequences of these molecules were compared using in silico approach. Bioinformatic databases of sequences of selected molecules at DNA, mRNA and protein level, such as GeneBank, …
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Determination of Thymic Epithelial Cell Composition and Proliferation During The Perinatal to Adult Transition
… of MHC class II and high-level expression of CD24 suggest that the UEA-1<sup>int</sup> Sca-1- subset contains immature TECs. Cells with this phenotype constitute a small subset of TEC in the wildtype thymus. The K5.D1 UEA-1<sup>int</sup> Sca-1- subset has a higher proliferative index compared …
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EWSR1 and FUS fusion genes in tumorigenesis
… an important function of FOX factors in LGFMS.CD24 was upregulated in the tumors and FUS-CREB3L2 expressing cells, and FUS-CREB3L2 was able to activate transcription through a CD24 regulatory sequence.
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Inflammation triggers Zeb1-dependent escape from tumor dormancy
… induction of Zeb1 led to the generation of CD29+ CD24- metastasis-initiating cells. In mice bearing dormant disseminated D2A1-d cells, my findings demonstrated that LPS-treatment resulted in the awakening of D2A1-d cells and metastatic outgrowth in the lungs and bone. The awakening of dormant …
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Gestörte Expression von CD70 und CD86 auf naiven CD27-B-Lymphozyten von Patienten mit Variablem Immundefektsyndrom (CVID)
… der Aktivierung (CD39, CD69), Differenzierung (CD24, CD27, CD38) oder der T- B- Zellwechselwirkung (CD25, CD70, CD86) aufwiesen. Wir stimulierten durch Zellsortierung gereinigte naive B- Zellen (CD19+CD27-IgM+IgDhighIgG-IgA-) von 10 CVID- Patienten und 10 gesunden Kontrollen für 4 Tage mit anti- …
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Constraints on the CD8 T cell response in chronic HBV infection
… and these ‘regulatory’ cells, identified as CD24 high CD38 high transitional, were selectively enriched in CHB and correlated with disease flares. Depletion of this subset rescued HBV-specific responses, implicating a pathogenic role in suppressing T cell function and viral persistence in …
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pH Regulatory Molecules In The Tumour Microenvironment: Modulators Of Aggressiveness And Immune Profile Of Human Hepatocellular Carcinoma
… for HCC stem cell-associated markers (<i>CD13, CD24, CD44, CD90, EpCAM, CD133, KRT19, OCT4, NANOG</i> and <i>SOX2</i>). Selected HCC, non-tumour and normal liver tissue samples were evaluated by immunohistochemistry (IHC) to detect the presence and localization of CAIX, CAXII and VATPase and to …
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Functional characterization of mobilized tumor cells
… 4) tyrosine kinase receptors. Surface antigen CD24 was found to be specifically and abundantly expressed in MPE, and was required for the colonization of the lung. In conclusion, metastatic inefficiency is due to the presence of inactive cells and cellular heterogeneity. Inactive cells are …
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The Role of Tumor Suppressor Dear1 In The Acquisition of Mammary Stem/Progenitor Cell Properties
… a basal-like phenotype through repression of CD24 and EpCAM expression. There is significant upregulation of master EMT and stem cell regulators, including SNAI2, in <em>DEAR1</em>-KD HMECs and I show that DEAR1 binds to and promotes polyubiquitination of SNAI2. I reveal a novel DEAR1-SNAI2 …
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Investigation of the anti-breast cancer efficacy and mechanisms of disulfiram
… such as aldehyde dehydrogenase (ALDH) and CD24-/CD44+ as well as Nanog, Sox2, and Oct4 were also suppressed. In PAC resistant cell line, DS abolished CSC characters and completely reversed PAC resistance. Lipo-DS blocked NFκB activation and specifically targeted CSCs in vitro. Lipo-DS also …
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Role of Mir-19A Released By Inflammatory Breast Cancer Cells In The Regulation of Dendritic Cell Functions: In Vitro Model of Crosstalk In The Tumor Microenvironment of Inflammatory Breast Cancer
… associated with the induction of CD44<sup>+</sup>CD24<sup>-</sup>ALDH1<sup>+</sup> cancer stem cells (CSCs) with epithelial-to-mesenchymal transition (EMT) characteristics.</p> <p>In conclusion, in IBC tumor microenvironment IL-6/miR-19a axis can represent a self-sustaining loop able to maintain a …
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Molecular Analysis of Breast Cancer Transcriptomes, Genomes, and Circulating Tumor DNA
… the CSC marker ALDH1 and the CSC phenotype CD44+/CD24- was correlated to alternatively spliced isoforms in tumors. The isoforms were differentially expressed in molecular subtypes and HER2 and EGFR positive tumors were associated to CD44S and CD44v8-10, respectively. In Paper II, by using targeted …
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Programmed cell death-ligand 1 (PD-L1) expression in HIV-associated diffuse large B-cell lymphoma – role and regulation
… the population of regulatory B cells (CD19+ CD24+ CD38+; median: 57.5% vs 61.2%; p = 0.5344) and PD-L1- positivity within this subset of B cells (CD19+ CD24+ CD38+ CD274+; median: 1.74% vs 0.83%; p = 0.3551) between HIV-negative and HIV-positive DLBCL patients. In the second approach, the …
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PLGA-DS reverses chemoresistance in malignant mesothelioma by targeting hypoxia induced cancer stem cells
… flow cytometry analysis of CSC markers such as CD24, CD133 and ABCG2. PLGA-DS/Cu also inhibited the hypoxiainduced NF-kB expression and blocked the migration and invasion ability of MM cells. It showed substantial toxicity to MM cell lines and reversed hypoxia-induced chemoresistance. Also, …
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Role of cancer stem cells in breast and prostate cancer
… culture significantly enriched for the CD44+/CD24- breast cancer stem cell phenotype when compared against 2D cell culture (p<0.05 and 0.001 respectively) and also enriched for expression of CD181 (p<0.05 and 0.001 respectively). However, this method did not enrich for the prostate CSC with …
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