Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 27 for “"CD23"”.
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CD23's Role as a Negative Regulator of Allergic Disease: in vivo Effects of Murine CD23 Destabilization and Allelic Mutations
… underexpression and overexpression studies, CD23 has been shown to negatively regulate IgE production. To investigate CD23 destabilization and its effects on CD23 shedding and IgE synthesis in vivo, we utilized an anti-CD23 stalk monoclonal (19G5) which has previously been shown to enhance …
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The CD23 receptor-regulation of expression and signal transduction
Bisher sind zwei Isoformen des humanen CD23 (CD23a und CD23b) beschrieben. Beide unterscheiden sich lediglich in 6-7 Resten im N-terminalen, zytoplasmatischen Anteil. CD23a wird ausschließlich auf B-Zellen exprimiert, während CD23b sowohl auf B-Zellen als auch auf Monozyten, eosinophilen …
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IGE PRODUCTION REGULATION VIA CD23 STALK ENGAGEMENT AND CELL CYCLE STIMULATION
CD23, the low affinity receptor for IgE, is expressed mainly on B cells and has been shown to regulate IgE production. Previously, recombinant mouse and human CD23 were constructed with a trimerizing isoleucine zipper motif attached in frame to the N-terminus of the entire extracellular CD23 …
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The role of human CD23 in lgE homeostasis & allergic disease
CD23, the low affinity receptor for IgE on B cells, exists in membrane and soluble<br/>forms. CD23 also binds CD21 with a distinct binding site to IgE. Soluble CD23<br/>(sCD23) fragments are released from trimeric membrane CD23 (mCD23) by the<br/>endogenous metalloprotease, ADAM10. It has been …
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Protein engineering and characterization of a stable trimeric form of CD23 and a fluorescent IgE biosensor
… form a complex with its low affinity receptor, CD23, and CD21 on the B cell surface to regulate IgE synthesis. Hence, there are two possible strategies in the therapy of IgE-mediated disease: blocking IgE binding to FceRI and inhibiting IgE production. Crystal log raphic and FRET studies with a …
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B cell ADAM10 Activity is Increased by Kainate Receptor Activation: Potential Role of this Pathway in Th2 Immunity and Cancer
CD23 has long been appreciated to be a natural, negative regulator of IgE synthesis. This understanding is due in part to animal models in which CD23 deficient or CD23 transgenic animals display exacerbated or reduced IgE levels respectively. Interestingly, CD23 is susceptible to proteolytic …
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Integrin-ligand interactions and cytokine production by monocytic cells
CD23 is a Type II glycoprotein that exists in both membrane-bound (mbCD23) and soluble (sCD23) forms and functions as the low affinity receptor for IgE. CD23 interacts with a range of proteins to fulfil its function in vivo. Through interactions with its ligands IgE and CD21, CD23 regulates the …
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Alpha v beta 5 and related receptors in human B lymphocyte development
CD23 is a multi-functional protein which exists in membrane-bound and soluble forms. Its functions include acting as the low affinity receptor for IgE and generating pro-inflammatory cytokine release in monocytes. CD23 has been found to interact with αvβ5 and this interaction greatly enhances …
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Expression and function of the αVβ5 integrin during human B lymphopoiesis
The integrin αVβ5 is a receptor for sCD23 molecule and the αVβ5-CD23 interaction sustains proliferation of the pre-B cell line SMS-SB. This thesis describes further investigation into the role of αVβ5 integrin during human B cell development. B cell development in the bone marrow involves stepwise …
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The Role of ADAM10 in the Immune System: Maintenance of Lymphoid Architecture, MDSC Development and Function, B cell Derived Exosomal Antigen Presentation, and B1 cell IgE Production.
… mouse. Lastly, ADAM10 is the key sheddase for CD23 on B2 cells. When IgE is bound to its antigen to form an immune complex, IC, it binds CD23 and is internalized. After CD23 bound to IgE ICs is internalized, it is sorted into bexosomes. These bexosomes are transferred to dendritic cells which …
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Transkriptionelle Regulation des CD23a-Promotors in Zellen chronischer lymphatischer Leukämien vom B-Zelltyp
… charakterisiert ist, wurde in dieser Arbeit der CD23a-Core-Promotor näher betrachtet. Ein besonderes Augenmerk galt dabei putativen Bindungsstellen für STAT6. Das Bindungsverhalten von Transkriptionsfaktoren an Promotor-DNA wurde mit Gel-Retardierungsexperimenten (EMSA) untersucht. Hierzu wurden …
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The Role of RNA Helicase RHAU in Immunoglobulin Class Switch Recombination
… Rhau</em> alleles in mouse B cells using a CD23-cre transgene. <em>Rhau</em><sup>D/D</sup> B cells show decreased <em>in vitro</em> CSR to IgG1 and <em>Rhau</em><sup>D/D</sup> mice display decreased IgG1, IgA, and IgG3 titers, suggesting that RHAU regulates CSR.</p>
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Interleukin-10 und Interleukin-12 produzierende Monozyten-Subpopulationen bei Normalpersonen und Probanden mit atopischer Diathese
… CD11b, CD14 und CD86, aber kein CD16, CD23 und CD80. Die Regulation der IL-10 und IL-12 Bildung wurde durch Vorinkubation der Monozyten mit verschiedenen Zytokinen untersucht. IFN-gamma steigert die IL-12 Bildung um ein Vielfaches und unterdrückt die IL-10 Bildung. IL-10 unterdrückt …
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Identifizierung differentiell exprimierter Gene mit potentiellem Einfluß auf die Entwicklung transitionaler B-Zellen zu reifen B-Zellen der Milz
… Über die Anfärbung der Oberflächenmoleküle CD21, CD23 und IgM konnten die einzelnen B-Zell-Populationen mit einer Reinheit von 95 sortiert werden und die daraus isolierte mRNA für die Hybridisierung des Mikroarrays Mu11K von Affymetrix verwendet werden. Von den transkribierten Genen zeigen im …
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Molekulare und funktionelle Analyse von Lymphocyten aus Patienten mit primären Immundefizienzerkrankungen
… die erhöhte Konzentrationen an löslichem CD23 im Serum aufweisen, da das Molekül eine Funktion in der Vermittlung von Entzündungsreaktionen besitzt. <br>Zusätzlich wurden Lymphocyten eines Patienten mit Hyper-IgM-Syndrom untersucht. <br>Ebenso wie in anderen Formen des Hyper-IgM Syndroms …
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