Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"CD200"”.
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CD200: A Novel Therapeutic Target for Chronic Lymphocytic Leukemia
… In this thesis, we investigated the role of CD200, a potent immunoregulatory molecule, in Chronic Lymphocytic Leukemia. We showed that functional blockade of CD200 on lymphoma cells or primary CLL cells, both of which express CD200 at high levels, augmented cytotoxic killing of these cells by …
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Putative Roles of Cd200 In The Leukemogenesis and Immune Evasion of Leukemia Stem Cells
… publicly available datasets and identified CD200 as a potential stem-cell specific immune checkpoint in AML. We hypothesized that CD200 was a stem-cell specific mechanism of evading immune detection and destruction and that anti-CD200 antibody therapy could effectively eliminate AML LSCs by …
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Characterization of skeletal stem cells derived from different musculoskeletal locations
… Prx1 cell populations, subpopulations P1 (CD105-CD200+), P2(CD105-CD200-), and P3 (CD105+) from bone marrow, periosteum and muscle were analyzed by bulk RNA sequencing. Results showed P2/P3 from bone marrow and periosteum were relatively active, while all muscle resident Prx1+ cells were …
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Influenza infection induces neuroinflammation and impacts hippocampal structure and function
… neurotrophic (BDNF, NGF), and immunomodulatory (CD200, CX3CL1) factors. To better understand the cellular mechanisms underlying these effects, changes in microglia reactivity and hippocampal neuron morphology were assessed at the same timepoint in which heightened inflammation and cognitive …
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Identification and characterization of epithelial progenitor niches in skin
… and exclusive presence of both Tbc1d10c and CD200 proteins in TD keratinocytes eventually led us to find that they were epidermal Merkel cell progenitors. Their progenitor characteristics were validated using skin reconstitution assay and in vivo lineage tracing by EdU incorporation. Our …