Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 43 for “"CD20"”.
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The Selection of Aptamers to CD20 and Their Application as Inhibitors of Complement Dependent Cytotoxicity
CD20 is an important oncological B-cell marker. Immunotherapy, using anti-CD20 antibodies, has revolutionized the treatment of B-cell cancers. Aptamers are highly specific DNA ligands, raised to identify virtually any target molecule through an iterative process known as SELEX (systematic evolution …
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Estudo da distribuição e quantificação dos linfócitos CD8 e CD20 nas lesões inflamatórias periapicais crônicas
… quantificar as populações linfocitárias CD8+ e CD20+ em lesões inflamatórias periapicais crônicas. Foram utilizadas 90 lesões inflamatórias periapicais. Através da técnica de imunohistoquímica pelo método da estreptoavidina-biotina, utilizou-se os marcadores CD8 e CD20 para identificação dos …
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The synergistic interaction between CD20 monoclonal antibodies and Histone Deacetylase inhibitors in B cell Non Hodgkin’s Lymphoma
… into treatment<br/>paradigms. The anti-CD20 monoclonal antibody, Rituximab, has resulted in<br/>dramatic improvements in survival for patients with B cell Non Hodgkin’s<br/>lymphoma. Histone deacetylase inhibitors are a novel class of anti cancer<br/>agents targeting epigenetic …
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Papel del anticuerpo monoclonal anti-CD20 (rituximab) en el tratamiento del lupus eritematoso sistémico refractario al uso de inmunsupresores
La presente tesis parte de la siguiente hipótesis de trabajo: El uso de Rituximab en pacientes con LES refractarios a inmunosupresores provoca una mejora tanto de los marcadores clínicos, como analíticos, así como, una reducción de los tratamientos coadyu
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Estudio Farmacogenético de la Respuesta al Anticuerpo Monoclonal Anti-CD20 (Rituximab) en el Tratamiento de Pacientes con Linfoma Folicular.
… un anticuerpo monoclonal quimérico anti-CD20, como inmunoterapia en el tratamiento del linfoma folicular se ha convertido en una terapia esencial, mejorando de forma significativa la supervivencia y presentando un perfil de toxicidad aceptable. Sin embargo, todavía existen dos restos …
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Understanding the Mechanism of Action of Rituximab in the Reversal of Multidrug Resistance in a Non-Hodgkins Lymphoma Cell Line
It has been previously demonstrated that an anti-CD20 monoclonal antibody (MAb) can reverse MDR in B lymphoma cells in vitro. However, the mechanisms underlying this effect are unknown. A recent study showed that anti-CD20 MAbs could induce rapid redistribution of CD20 into a detergent-insoluble …
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Potentiating Antibody Therapy by Targeting Complement on Cancer Cells
… lead to treatment failure. Loss of cell surface CD20 can occur in the treatment of lymphoid malignancies with anti-CD20 antibodies (mAbs) (eg rituximab, ofatumumab) through trogocytosis. This is a frustrated form of phagocytosis, where the target CD20 antigen is removed with a piece of target …
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Chimeric ANTI-CD19 Monoclonal Antibodies for the Treatment of Precursor B Cell Acute Lymphoblastic Leukemia
… immunotherapies for them are based on anti-CD20 monoclonal antibodies (MAbs). However, CD20 is not expressed on precursor B cell acute lymphoblastic leukemia (pre-B ALL), and CD20 expression is often lost following anti-CD20 immunotherapy. CD19 is a pan B cell membrane antigen that is …
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Participação das subpopulações de linfócitos T na lesão granulomatosa
… marcadores moleculares CD4, CD8, CD25, CTLA-4, CD20, CD75, CD3 e CD45RO, demonstrou que em todos os casos houve uma importante migração de células com fenótipo CD3+, CD45RO+, CD20+ e CD75+. Analisando estes marcadores observaram-se uma correlação positiva entre os marcadores CD3 e CD45RO e entre …
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Probing the sensitivity of autoantibody production to B cell depletion by Rituximab
… a monoclonal antibody directed against the human CD20 antigen, causes profound depletion of all B cells. When used in patients with autoimmune disease, IgG autoantibody titres often fall whilst serum IgG anti-tetanus toxoid antibody titres are unaffected. Antibodies of both these antibody …
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Die B-Lymphozyten-Aktivierung in der osteoarthrotischen Synovialmembran - ein Beitrag zum molekularpathogenetischen Verständnis der Osteoarthrose
… B-Zell-Ansammlugen analysiert. Durch CD27/CD20– und CD27/Syndekan-Doppelfärbungen konnte die bevorzugte Lokalisation von Memory-und Plasma-Zellen identifiziert werden. Diese gab nähere Hinweise auf den Ort der Antigen-Aktivierung bei Osteoarthrose. Die Resultate der hohen R/S-Ratios (17/24 …
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MODULATION OF THE B-CELL REPERTOIRE IN RHEUMATOID ARTHRITIS BY TRANSIENT B-CELL DEPLETION
… patients were treated with rituximab, an anti-CD20 monoclonal antibody that selectively depletes peripheral CD20+ B-cells for several months. The B-cell repertoire was studied before therapy and at the earliest time point after B-cell regeneration in both patients. A longer follow-up (up to 27 …
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Genomic aberrations as determinants of immune infiltrates in high grade serous ovarian carcinoma
… IHC protocols against CD3, CD8, FOXP3 and CD20, and quantified the total, tumour and stroma densities of CD3+, CD8+, CD8−, FOXP3+ and CD20+cells in the patient cohort using HALO image analysis software. I also quantified the abundance of other immune cells in the samples using gene …
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Immune Infiltrates in Breast Cancer: Clinical Significance from Histopathology to Prognosis
… a paucity of information on the significance of CD20+ (B-cells) TILs. To better elucidate the individual prognostic associations of the above TILs, and study the prognostic interplay of each, this thesis aims to evaluate the association between breast cancer-specific survival (BCSS) and CD8+, …
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Fc Gamma Receptors Facilitate Antigenic Modulation of LILRB4 and Function as Predictive Biomarkers in Acute Monocytic Leukemia
… shown to reduce the effector function of anti-CD20 antibodies targeting B cell malignancies.</p> <p>Through this Fc-mediated mechanism, the anti-LILRB4 mAb and others bind their target receptor, inducing internalization of the antigen complex. In the case of anti-LILRB4, this antigenic …
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Meningeal B cells in central nervous system autoimmunity: Their phenotype and susceptibility to therapeutic depletion
… activation status. Following treatment with anti-CD20, B cells were rapidly depleted in peripheral tissues such as the blood, lymph node and spleen, while depletion in the CNS was delayed. Following treatment there was minimal evidence that anti-CD20 accessed meningeal B cells directly, but rather …
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Immunzellen in primären und metastasierten gastrointestinalen Stromatumoren (GISTs)
… Lymphozyten (T-Lymphozyten: CD3, B-Lymphozyten: CD20, NK-Zellen: CD56) in diesen Proben untersucht. Hierzu wurden die Paraffinblöcke der Exzisionspräparate oder der Stanzbiopsien mit Hilfe eines manuellen Tissue-Arrayer in einem Empfängerparaffinblock (TMA) nebeneinander in 22 TMAs aufgereiht. …
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